scholarly journals Genetic Determinants of Chronic Obstructive Pulmonary Disease in South Indian Male Smokers

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e89957 ◽  
Author(s):  
Cholendra Arja ◽  
Rajasekhara Reddy Ravuri ◽  
Venugopal N. Pulamaghatta ◽  
Krishna Mohan Surapaneni ◽  
Premanand Raya ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Genetic Determinants ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Indian Male

Oxidative stress and antioxidant enzyme activity in South Indian male smokers with Chronic Obstructive Pulmonary Disease

Respirology ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Arja Cholendra ◽  
Surapaneni Krishna Mohan ◽  
Raya Premanand ◽  
Adimoolam Chandrasekar ◽  
Balisetty Badhareenadhudu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Pulmonary Disease ◽  
Antioxidant Enzyme Activity ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Indian Male

scholarly journals Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Sangeetha Vishweswaraiah ◽  
Tania Ahalya Thimraj ◽  
Leema George ◽  
Chaya Sindaghatta Krishnarao ◽  
Komarla Sundararaja Lokesh ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Tobacco Smoke ◽  
Indian Population ◽  
Chronic Obstructive ◽  
South Indian Population ◽  
Rural South ◽  
Obstructive Pulmonary Disease ◽  
Biomass Smoke ◽  
South Indian

Rationale. Exposure to biomass smoke (BMS) has been implicated in chronic obstructive pulmonary disease (COPD). About 3 billion people worldwide use biomass fuel for cooking and heating. Women in rural communities of low- and lower-middle-income countries are disproportionately exposed to massive amounts of BMS during active cooking hours (4–6 h/day). Therefore, BMS exposure is considered as a risk factor for COPD in the same order of magnitude as tobacco smoke. In rural India, due to cultural reasons, women are the primary cook of the family and are mostly nonsmokers. Thus, BMS-induced COPD is predominant among rural Indian women. However, BMS-COPD remains a relatively unexplored health problem globally. Therefore, we investigated the serum chemokine and cytokine signatures of BMS-COPD and tobacco smoke-induced COPD (TS-COPD) patients compared to their control in a rural South Indian population for this field study. Methods. Concentrations of 40 serum chemokines and cytokines were measured using a multiplexed immunoassay. The study cohort consisted of BMS-COPD (female; n=29) and BMS-exposed subjects without COPD (BMS-CONTROL; female; n=24). For comparison, data from TS-COPD patients (male, n=23) and tobacco smokers without COPD (TS-CONTROL; male, n=22) were investigated. Subjects were matched for age, sex, and biomass exposure. Tobacco consumption was slightly higher in TS-COPD subjects compared to TS-CONTROL. BMS-exposed and TS-exposed subjects (currently exposed) were from the same locality with similar dwelling habits and socioeconomic status. A validated structured questionnaire-based survey and spirometry was performed. An additional control group with no tobacco and BMS exposure (TS-BMS-CONTROL; n=15) was included. Statistical significance was set at p≤0.01. Results. Serum median concentrations (pg/ml) of CCL15 [8799.35; 5977.22], CCL27 [1409.14; 1024.99], and CXCL13 [37.14; 26.03] were significantly higher in BMS-CONTROL compared to BMS-COPD subjects. Nine analytes exhibited higher concentrations in TS-CONTROL compared to TS-COPD subjects. Comparison of chemokine and cytokine concentrations among BMS-COPD versus TS-COPD and BMS-CONTROL versus TS-CONTROL subjects also revealed distinct molecular signatures. Conclusion. Our data identifies CCL27 and CXCL13 as putative, plausibly homeostatic/protective biomarkers for BMS-COPD within the investigated population that warrants validation in larger and multiple cohorts. The findings further indicate exposure-specific systemic response of chemokines and cytokines.

scholarly journals Genetic and epigenetic heterogeneity of chronic obstructive pulmonary disease

2020 ◽  
Vol 131 (2) ◽  
pp. 15-22
Author(s):  
M.A. Sadvokasova ◽  
◽  
B.A. Azimkhanova ◽  
А.А. Аripova ◽  
A.Yu. Akparova ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Dna Methylation ◽  
Chronic Disease ◽  
Pulmonary Disease ◽  
Tobacco Smoke ◽  
Chronic Obstructive ◽  
Pathological Changes ◽  
Genetic Determinants ◽  
Obstructive Pulmonary Disease ◽  
The Impact

Chronic obstructive pulmonary disease (COPD) is a global chronic disease of the respiratory system. The formation of pathological changes in the lungs is primarily associated with the impact of harmful chemicals of the tobacco smoke on the epithelium of the respiratory tract. In addition to the activation of key COPD processes, an important role in the development of the disease played by genetic determinants and disruption of epigenetic regulation, including changes in DNA methylation, histone modification, and microRNA expression. The article discusses the genetic and epigenetic aspects of COPD as a heterogeneous disease with a complex pathogenesis.

The study on effect of home based pulmonary rehabilitation in chronic obstructive pulmonary disease

2020 ◽  
Vol 10 (2) ◽  
pp. 52-56
Author(s):  
Kalaichandar M ◽  
Kirubakaran K ◽  
Baskaran V ◽  
Kokila K ◽  
Jeevitha M ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Pulmonary Rehabilitation ◽  
Indian Population ◽  
Rehabilitation Program ◽  
Chronic Obstructive ◽  
South Indian Population ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Home Based

Chronic obstructive pulmonary disease(COPD) is a leadingcauseof mortality and morbidity globally (3 million deaths in 2012). COPD is common in older population and kills on average one person every 10 seconds. In 2002, COPD was the fifth leading cause of death. Total deaths from COPD are proposed to grow through more than 30% in the next 10 years. Estimations indicate that COPD in 2030 turns into the 0.33 main reason for the loss of life worldwide. The WHO estimate quotes a figure of almost 5,56,000 deaths attributable to COPD in the SoutheastAsian region, which majorly comprises India. The challenge in both treatment and prevention of COPD remains the same. Despite major improvement in health care particularly in the treatment of COPD, the mortality due to COPD tends to be high and is expected to increase in the future according to . Use intolerance is an individual and a disturbing appearance of the disease. Lack of physical activity in COPD patients contributes a major complication to the disease. Oral or inhaled medicine have incomplete role in cultivating the physical capacity of these patients. So the main aim of treatment is control of symptoms, decreasing exacerbation frequency and hospitalization rates, maximizing lung function, refining the quality of life and implementation capacity by means of pulmonary reintegration. Extensive search of literature has not revealed larger data on effect of pulmonary rehabilitation in management of COPD pertaining to South Indian population. Hence, the present study was undertaken to assess the effect of home based rehabilitation program in South Indian population.

Sign in / Sign up

Export Citation Format

Share Document