Oxidative stress and antioxidant enzyme activity in South Indian male smokers with Chronic Obstructive Pulmonary Disease

Respirology ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Arja Cholendra ◽  
Surapaneni Krishna Mohan ◽  
Raya Premanand ◽  
Adimoolam Chandrasekar ◽  
Balisetty Badhareenadhudu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Pulmonary Disease ◽  
Antioxidant Enzyme Activity ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Indian Male

scholarly journals Genetic Determinants of Chronic Obstructive Pulmonary Disease in South Indian Male Smokers

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e89957 ◽  
Author(s):  
Cholendra Arja ◽  
Rajasekhara Reddy Ravuri ◽  
Venugopal N. Pulamaghatta ◽  
Krishna Mohan Surapaneni ◽  
Premanand Raya ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Genetic Determinants ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Indian Male

Altered Angiotensin I Conversion in Pulmonary Disease

1976 ◽  
Vol 51 (6) ◽  
pp. 537-543 ◽  
Author(s):  
Suzanne Oparil ◽  
J. Low ◽  
T. J. Koerner
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Enzyme Activity ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Specific Method ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Physiological Concentration ◽  
Obstructive Pulmonary Disease ◽  
Shock Lung

1. A specific method is described for the measurement of angiotensin I converting enzyme activity in plasma with 125I-labelled angiotensin I used as substrate. 2. Converting enzyme activity in plasma from fifteen normal subjects, eleven patients with sarcoidosis, twelve patients with chronic obstructive pulmonary disease and three patients with shock lung was assayed by this technique. 3. Patients with sarcoidosis had increased plasma converting enzyme activity whether or not they were receiving steroid therapy. 4. Patients with chronic obstructive pulmonary disease and shock lung had decreased plasma converting enzyme activity, but extent of conversion did not correlate with the severity of the lung disease. 5. Converting enzyme activity in normal plasma could be completely inhibited by addition of exogenous angiotensin I in 0·5–2·5 × 107 times physiological concentration. Twice as much exogenous angiotensin I was needed to inhibit conversion completely in plasma from patients with sarcoidosis; one tenth as much in chronic obstructive pulmonary disease. These results indicate that plasma has a high capacity for angiotensin I conversion even in patients with pulmonary parenchymal disease. 6. Results suggest that plasma converting enzyme activity may be a reflection of pulmonary conversion and can be altered by pulmonary disease. 7. Measurement of plasma converting enzyme activity may be useful in studies designed to characterize the regulatory role of converting enzyme in the renin—angiotensin system and in cardiovascular homeostasis.

Oxidized low-density lipoproteins and its connection with dyslipidemia, inflammatory markers, and oxidative stress in patients with occupational chronic obstructive pulmonary disease

2021 ◽  
Vol 31 (4) ◽  
pp. 456-462
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova ◽  
V. V. Troshin ◽  
V. D. Fedotov
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Comparison Group ◽  
Serum Levels ◽  
Low Density Lipoproteins ◽  
Chronic Obstructive ◽  
Low Density ◽  
Obstructive Pulmonary Disease ◽  
Occupational Copd

The role of low-density oxidized lipoproteins (OxLDL) in the pathogenesis of occupational chronic obstructive pulmonary disease (COPD) is not understood well enough.The study aims to determine the serum levels of oxidized low-density lipoproteins and their relationship with lipid profile, the level of oxidative stress and level C-reactive protein in patients with occupational chronic obstructive pulmonary disease.Methods. 116 patients diagnosed with occupational COPD and 25 patients with no respiratory diseases (comparison group) were examined. Serum levels of OxLDL was determined by solid phase enzyme-linked immunosorbent assay (ELISA) using the commercial reagent kit MDA-oxLDL from Biomedica Gruppe, Austria.Results. Circulating OxLDL was detected in serum in a significant proportion of patients with stable occupational COPD. In most of the patients, the concentration of OxLDL was within the values observed in the comparison group or exceeded them by no more than two times. In the minority of patients with occupational COPD (16.5%), the concentration of OxLDL was high and 4 – 10 times higher than its average value in the comparison group. It can be assumed that the revealed differences in the concentration of OxLDL are due to the different degree and intensity of oxidation of low-density lipoproteins. The relationships between OxLDL and lipid metabolism, oxidative stress (OS), the antioxidant capacity of serum (AOS), and serum levels of C-reactive protein were described.Conclusion. Serum OxLDL levels in patients with occupational COPD, the relationship between OxLDL and lipid metabolism, oxidative stress, and inflammation will provide an expanded view of the pathogenetic aspects of occupational COPD.

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