scholarly journals Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Asimuddin Mohammed ◽  
Vijayalakshmi Gutta ◽  
Mohd Soheb Ansari ◽  
Rajagopal Saladi Venkata ◽  
Kaiser Jamil
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Pulmonary Disease ◽  
Indian Population ◽  
Antioxidant Enzyme Activity ◽  
Chronic Obstructive ◽  
South Indian Population ◽  
Obstructive Pulmonary Disease ◽  
South Indian

Oxidative stress and antioxidant enzyme activity in South Indian male smokers with Chronic Obstructive Pulmonary Disease

Respirology ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Arja Cholendra ◽  
Surapaneni Krishna Mohan ◽  
Raya Premanand ◽  
Adimoolam Chandrasekar ◽  
Balisetty Badhareenadhudu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Pulmonary Disease ◽  
Antioxidant Enzyme Activity ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Indian Male

scholarly journals Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Sangeetha Vishweswaraiah ◽  
Tania Ahalya Thimraj ◽  
Leema George ◽  
Chaya Sindaghatta Krishnarao ◽  
Komarla Sundararaja Lokesh ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Tobacco Smoke ◽  
Indian Population ◽  
Chronic Obstructive ◽  
South Indian Population ◽  
Rural South ◽  
Obstructive Pulmonary Disease ◽  
Biomass Smoke ◽  
South Indian

Rationale. Exposure to biomass smoke (BMS) has been implicated in chronic obstructive pulmonary disease (COPD). About 3 billion people worldwide use biomass fuel for cooking and heating. Women in rural communities of low- and lower-middle-income countries are disproportionately exposed to massive amounts of BMS during active cooking hours (4–6 h/day). Therefore, BMS exposure is considered as a risk factor for COPD in the same order of magnitude as tobacco smoke. In rural India, due to cultural reasons, women are the primary cook of the family and are mostly nonsmokers. Thus, BMS-induced COPD is predominant among rural Indian women. However, BMS-COPD remains a relatively unexplored health problem globally. Therefore, we investigated the serum chemokine and cytokine signatures of BMS-COPD and tobacco smoke-induced COPD (TS-COPD) patients compared to their control in a rural South Indian population for this field study. Methods. Concentrations of 40 serum chemokines and cytokines were measured using a multiplexed immunoassay. The study cohort consisted of BMS-COPD (female; n=29) and BMS-exposed subjects without COPD (BMS-CONTROL; female; n=24). For comparison, data from TS-COPD patients (male, n=23) and tobacco smokers without COPD (TS-CONTROL; male, n=22) were investigated. Subjects were matched for age, sex, and biomass exposure. Tobacco consumption was slightly higher in TS-COPD subjects compared to TS-CONTROL. BMS-exposed and TS-exposed subjects (currently exposed) were from the same locality with similar dwelling habits and socioeconomic status. A validated structured questionnaire-based survey and spirometry was performed. An additional control group with no tobacco and BMS exposure (TS-BMS-CONTROL; n=15) was included. Statistical significance was set at p≤0.01. Results. Serum median concentrations (pg/ml) of CCL15 [8799.35; 5977.22], CCL27 [1409.14; 1024.99], and CXCL13 [37.14; 26.03] were significantly higher in BMS-CONTROL compared to BMS-COPD subjects. Nine analytes exhibited higher concentrations in TS-CONTROL compared to TS-COPD subjects. Comparison of chemokine and cytokine concentrations among BMS-COPD versus TS-COPD and BMS-CONTROL versus TS-CONTROL subjects also revealed distinct molecular signatures. Conclusion. Our data identifies CCL27 and CXCL13 as putative, plausibly homeostatic/protective biomarkers for BMS-COPD within the investigated population that warrants validation in larger and multiple cohorts. The findings further indicate exposure-specific systemic response of chemokines and cytokines.

The study on effect of home based pulmonary rehabilitation in chronic obstructive pulmonary disease

2020 ◽  
Vol 10 (2) ◽  
pp. 52-56
Author(s):  
Kalaichandar M ◽  
Kirubakaran K ◽  
Baskaran V ◽  
Kokila K ◽  
Jeevitha M ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Pulmonary Rehabilitation ◽  
Indian Population ◽  
Rehabilitation Program ◽  
Chronic Obstructive ◽  
South Indian Population ◽  
Obstructive Pulmonary Disease ◽  
South Indian ◽  
Home Based

Chronic obstructive pulmonary disease(COPD) is a leadingcauseof mortality and morbidity globally (3 million deaths in 2012). COPD is common in older population and kills on average one person every 10 seconds. In 2002, COPD was the fifth leading cause of death. Total deaths from COPD are proposed to grow through more than 30% in the next 10 years. Estimations indicate that COPD in 2030 turns into the 0.33 main reason for the loss of life worldwide. The WHO estimate quotes a figure of almost 5,56,000 deaths attributable to COPD in the SoutheastAsian region, which majorly comprises India. The challenge in both treatment and prevention of COPD remains the same. Despite major improvement in health care particularly in the treatment of COPD, the mortality due to COPD tends to be high and is expected to increase in the future according to . Use intolerance is an individual and a disturbing appearance of the disease. Lack of physical activity in COPD patients contributes a major complication to the disease. Oral or inhaled medicine have incomplete role in cultivating the physical capacity of these patients. So the main aim of treatment is control of symptoms, decreasing exacerbation frequency and hospitalization rates, maximizing lung function, refining the quality of life and implementation capacity by means of pulmonary reintegration. Extensive search of literature has not revealed larger data on effect of pulmonary rehabilitation in management of COPD pertaining to South Indian population. Hence, the present study was undertaken to assess the effect of home based rehabilitation program in South Indian population.

scholarly journals Association of Elevated Serum GM-CSF, IFN-γ, IL-4, and TNF-α Concentration with Tobacco Smoke Induced Chronic Obstructive Pulmonary Disease in a South Indian Population

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ankita Mitra ◽  
Sangeetha Vishweswaraiah ◽  
Tania Ahalya Thimraj ◽  
Mahendra Maheswarappa ◽  
Chaya Sindaghatta Krishnarao ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Disease ◽  
Pulmonary Disease ◽  
Obstructive Lung Disease ◽  
Indian Population ◽  
Chronic Obstructive ◽  
South Indian Population ◽  
Obstructive Pulmonary Disease ◽  
Gm Csf ◽  
South Indian

Background. Chronic obstructive pulmonary disease (COPD) is a devastating condition with limited pharmacotherapeutic options and exceptionally high public-health burden globally as well as in India. Tobacco smoking is the primary cause for COPD among men in India. Systemic inflammation involving altered regulation of cytokines controlling the host defense mechanism is a hallmark of COPD pathogenesis. However, biomarker discovery studies are limited among Indian COPD patients. Methods. We assessed the serum concentrations [median (25th-75th percentile) pg/ml] of interleukin (IL)-2,4,6,8,10, granulocyte macrophage colony stimulating factor (GM-CSF), interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α) using a multiplexed immunoassay. Our study cohort consisted of 30 tobacco smokers with COPD (TS COPD) and 20 tobacco smokers without COPD (TS CONTROL) from South India. The study population was matched for age, sex (male), and tobacco consumption (pack-years). COPD was diagnosed according to the global initiative for chronic obstructive lung disease (GOLD) criteria of persistent airflow obstruction determined by the ratio of postbronchodilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) of <0.7. A validated structured questionnaire-based survey [Burden of Obstructive Lung Disease (BOLD) study] and spirometry were performed during house to house visit of the field study. Statistical analysis included nonparametric (two-tailed) Mann–Whitney U and Spearman rank test, as appropriate (significance: p<0.05). Results. Serum GM-CSF [69.64 (46.67, 97.48); 36.78 (30.07, 53.88), p=0.014], IFN-γ [51.06 (17.00, 84.86); 11.70 (3.18, 32.81), p=0.017], IL-4 [9.09 (1.8, 19.9); 1.8 (1.8, 4.46); p=0.024], and TNF-α [20.68 (5.5, 29.26); 3.5 (3.5, 4.5); p<0.001] concentrations (pg/ml) were increased in TS COPD subjects compared to TS CONTROL. A weak correlation between lung function parameters and cytokine concentrations was detected. Conclusion. Our pilot study reveals GM-CSF, IFN-γ, IL-4, and TNF-α as plausible COPD susceptibility biomarkers within the investigated South Indian population that needs to be validated in a larger cohort.

Altered Angiotensin I Conversion in Pulmonary Disease

1976 ◽  
Vol 51 (6) ◽  
pp. 537-543 ◽  
Author(s):  
Suzanne Oparil ◽  
J. Low ◽  
T. J. Koerner
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Enzyme Activity ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Specific Method ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Physiological Concentration ◽  
Obstructive Pulmonary Disease ◽  
Shock Lung

1. A specific method is described for the measurement of angiotensin I converting enzyme activity in plasma with 125I-labelled angiotensin I used as substrate. 2. Converting enzyme activity in plasma from fifteen normal subjects, eleven patients with sarcoidosis, twelve patients with chronic obstructive pulmonary disease and three patients with shock lung was assayed by this technique. 3. Patients with sarcoidosis had increased plasma converting enzyme activity whether or not they were receiving steroid therapy. 4. Patients with chronic obstructive pulmonary disease and shock lung had decreased plasma converting enzyme activity, but extent of conversion did not correlate with the severity of the lung disease. 5. Converting enzyme activity in normal plasma could be completely inhibited by addition of exogenous angiotensin I in 0·5–2·5 × 107 times physiological concentration. Twice as much exogenous angiotensin I was needed to inhibit conversion completely in plasma from patients with sarcoidosis; one tenth as much in chronic obstructive pulmonary disease. These results indicate that plasma has a high capacity for angiotensin I conversion even in patients with pulmonary parenchymal disease. 6. Results suggest that plasma converting enzyme activity may be a reflection of pulmonary conversion and can be altered by pulmonary disease. 7. Measurement of plasma converting enzyme activity may be useful in studies designed to characterize the regulatory role of converting enzyme in the renin—angiotensin system and in cardiovascular homeostasis.

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