Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action for Herbal Medicines in Stroke Treatment and Prevention

For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH and BTH was developed. It is indicated that QEH compounds have high lipophilicity while BTH compounds possess high chemical reactivity. Secondly, a systematic investigation integrating ADME (absorption, distribution, metabolism, and excretion) prediction, target fishing and network analysis was performed and validated on these herbs to obtain the compound-target associations for reconstructing the biologically-meaningful networks. The results suggest QEH enhance physical strength, immune system and normal well-being, acting as adjuvant therapy for chronic disorders while BTH stimulate hematopoiesis function in body. As an emerging approach, the systems pharmacology model might facilitate to understand the mechanisms of action of the tonic herbs, which brings about new development for complementary and alternative medicine.

Download Full-text

Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action of Huo-Xiang-Zheng-Qi Formula for the Treatment of Gastrointestinal Diseases

Frontiers in Pharmacology ◽

10.3389/fphar.2018.01448 ◽

2019 ◽

Vol 9 ◽

Cited By ~ 14

Author(s):

Miaoqing Zhao ◽

Yangyang Chen ◽

Chao Wang ◽

Wei Xiao ◽

Shusheng Chen ◽

...

Keyword(s):

Gastrointestinal Diseases ◽

Mechanisms Of Action ◽

Systems Pharmacology ◽

Multi Scale

Download Full-text

Systems Pharmacology Dissection of Multiscale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.7b00505 ◽

2017 ◽

Vol 14 (9) ◽

pp. 3201-3217 ◽

Cited By ~ 20

Author(s):

Jinghui Wang ◽

Yan Li ◽

Yinfeng Yang ◽

Jian Du ◽

Miaoqing Zhao ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Herbal Medicines ◽

Mechanisms Of Action ◽

Systems Pharmacology

Download Full-text

Phytotherapy and Herbal Medicines for Kidney Stones

Current Drug Targets ◽

10.2174/1389450121666200929115555 ◽

2020 ◽

Vol 22 (1) ◽

pp. 22-30

Author(s):

Esteban Emiliani ◽

Adrian Jara ◽

Andres Koey Kanashiro

Keyword(s):

Uric Acid ◽

Calcium Oxalate ◽

Kidney Stones ◽

Animal Studies ◽

Randomized Clinical Trials ◽

Herbal Medicines ◽

Phyllanthus Niruri ◽

Treatment And Prevention ◽

Number Of Patients ◽

Uric Acid Stones

Background: Kidney stones are one of the oldest known and common diseases in the urinary tract with a prevalence that varies from 1% to 20%. Many phytotherapic and herbal medicines for kidney stones have been described for their treatment and prevention. Objective: The objective of this study is to perform a comprehensive review of several phytotherapic and herbal medicines published including clinical and animal studies. Results: Phytotherapy may influence the risk of recurrence in calcium oxalate and uric acid stones. The most solid evidence suggest that Phyllanthus niruri is one of the most studied components that appear to interfere with the calcium oxalate crystallization, reduced hyperoxaluria and hiperuricosuria and increased shock wave lithotripsy efficacy due to reduced crystallization without significant adverse effects, also Theobromine have shown to reduce the crystallization of uric acid in patients and appears to be a promising supplement to treat such stones. Conclusion: Many phytoterapic and herbal agents have been studies to treat and present urolithiasis, most of them only with studies of small number of patients or in animal models. Further randomized clinical trials are needed to evaluate the effect of these agents in kidney stones.

Download Full-text

Systems Pharmacology Dissection of Multi-Scale Synergistic Treatment Strategies of Chaihu Shugan Powder for Depression

Journal of Gynecological Oncology ◽

10.25107/2689-9396-v2-id1020 ◽

2018 ◽

Vol 2 (3) ◽

pp. 1-15

Author(s):

Yu-Jing Zhao ◽

Feng Li ◽

Qi-Lei Liu ◽

Yan Li

Keyword(s):

Treatment Strategies ◽

Systems Pharmacology ◽

Multi Scale

Download Full-text

Experience in treatment and prevention of respiratory diseases relapses in children with the use of the phytotherapeutic complex «Alpicol»: feedback of doctors in Ukraine

Modern pediatrics. Ukraine ◽

10.15574/sp.2021.117.12 ◽

2021 ◽

pp. 12-22

Author(s):

О.К. Koloskova ◽

◽

A.L. Kosakovskyi ◽

T.M. Bilous ◽

I.B. Horbatiuk ◽

...

Keyword(s):

Respiratory Tract ◽

Therapeutic Efficacy ◽

Respiratory Diseases ◽

Conflicts Of Interest ◽

Inflammatory Diseases ◽

Clinical Manifestations ◽

Herbal Medicines ◽

Upper Respiratory Tract ◽

Treatment And Prevention ◽

Parents And Children

Infectious and inflammatory diseases of the respiratory tract in children are the «leaders» among all pathologies of childhood. Optimization of therapeutic and prophylactic approaches for infectious and inflammatory pathologies of the respiratory system by reducing the frequency of unreasonable antibiotic therapy and eliminating polypragmatic use is a relevant problem of modern pediatrics and otolaryngology. According to WHO guidelines, modern standardized herbal medicines are not inferior in efficiency to synthetic ones. The aim — to analyze the results of assessment by doctors of the preventive and therapeutic efficacy of the remedy «Alpicol» on the basis of a questionnaire, as well as clinical examination of patients before using the medication and after completion of the course of treatment. Materials and methods. The advantages of «Alpicol» were analyzed through a questionnaire offered by first contact practitioners to children in order to receive feedback on the assessment of the preventive and therapeutic efficacy of this medication. Doctors from 9 regions of Ukraine were involved, and 6,093 questionnaires of children of different ages were analyzed. Results. The frequency of registration of a pronounced paediatric pain (3 scores) with the use of the «Alpicol» medication significantly decreased (23.7 times), a moderate manifestation of the disease (2 scores), was 17 times less at the same time, mild manifestations of paediatric pain remained at the same level. Patients with a comorbid pathology of the respiratory tract in the form of recurrent lesions of the upper and lower airways during the 2nd visit received a zero score (no symptoms) significantly less frequently than children with pathology of the upper respiratory tract with 62.6% of cases versus 72.2% of observations, respectively (p<0.05). As a result of the use of the course of «Alpicol» medication, a statistically significant decrease in the severity of the catarrhal symptom complex was achieved, since the proportion of the course of disease, assessed by the maximum number of scores, decreased by 29.6 times, moderate (score 2) — 13.3 times, and zero scores appeared 5.7 times more often. At the same time, the proportion of patients with a mild course of catarrh practically did not change. Conclusions. «Alpicol» has a multi;vector efficacy against the complex of symptoms that accompany infectious and inflammatory exacerbations of recurrent respiratory diseases. This is manifested by a decrease in the severity of clinical manifestations of the disease, as well as in an increase in cases of clinical stabilization of the patient's condition, which demonstrates the therapeutic and prophylactic effect of the drug «Alpicol» on the course of recurrent respiratory diseases in children. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was adopted by the Local Ethics Committee of all institutions indicated in this research. The informed consent of parents and children was obtained. The authors declare that they have no conflicts of interest. Key words: ecurrent respiratory diseases, treatment and prevention, children, phytocomplexes.

Download Full-text

THE USE OF THE HERBAL PREPARATION EVIKA IN THE TREATMENT OF PREMENSTRUAL SYNDROME

Farmaciâ Kazahstana ◽

10.53511/pharmkaz.2021.39.38.010 ◽

2021 ◽

pp. 50-55

Author(s):

Л. И. НУРГАЛИЕВА ◽

Д.М. КУАТБЕКОВА

Keyword(s):

Quality Of Life ◽

Herbal Medicine ◽

Reproductive Health ◽

Premenstrual Syndrome ◽

Herbal Medicines ◽

The State ◽

Herbal Preparation ◽

Treatment And Prevention ◽

Symptom Complex

Предменструальный синдром (ПМС) - патологический симптомокомплекс, который значительно снижает качество жизни женщины. Несмотря на то, что этиология и патогенез до настоящего времени изучены недостаточно, определены направления в диагностике, лечении и профилактике, которым необходимо следовать. Лечение ПМС должно быть дифференцированным, учитывающим состояние общего и репродуктивного здоровья женщины, сопутствующие заболевания, степень тяжести ПМС, переносимость терапии и т. д.В настоящее время все более широкое применение в лечении ПМС находят фитопрепараты (ФП). Целью исследования явилось изучение эффективности фитопрепарата «Эвика» в лечении ПМС легкой и средней формы. Полученные результаты свидетельствуют об эффективности данного препарата в устранении вегетососудистых, отечных и психоэмоциональных симптомов ПМС, что определяет «Эвику», как препарат выбора у пациенток с ПМС, выраженной вегетососудистой и психоэмоциональной симптоматики. Premenstrual syndrome (PMS) is a pathological symptom complex that significantly reduces a woman's quality of life. Despite the fact that the etiology and pathogenesis have not been studied enough to date, the directions in diagnosis, treatment and prevention that need to be followed have been identified. Treatment of PMS should be differentiated, taking into account the state of a woman's general and reproductive health, concomitant diseases, the severity of PMS, the tolerability of therapy, etc. Currently, herbal medicines are increasingly used in the treatment of PMS. The aim of the study was to learn the effectiveness of the herbal medicine "Eviсa" in the treatment of mild and moderate PMS. The results obtained indicate the effectiveness of this drug in eliminating vegetativevascular, edematous and psychoemotional symptoms of PMS, which defines "Evica" as the medication of choice in patients with PMS, vegetativevascular and psychoemotional symptoms.

Download Full-text