Multivariable Logistic Regression Model: A Novel Mathematical Model that Predicts Visual Field Sensitivity from Macular Ganglion Cell Complex Thickness in Glaucoma

Abstract Background The use of intraoperative topical vancomycin (VAN) is a strategy aimed to prevent surgical site infections (SSI). Although there is evidence to support its efficacy in SSI prevention following orthopedic spine surgeries, data describing its safety, specifically acute kidney injury (AKI) risk, is limited. The purpose of this study was to determine the AKI incidence associated with intraoperative topical VAN. Methods This is a retrospective cohort study reviewing patient encounters where intraoperative topical VAN was administered from February 2018 to July 2018. All adult patients ( ≥18 years) that received topical VAN in the form of powder, beads, rods, paste, cement spacers, or unspecified topical routes were included. Patient encounters were excluded for AKI or renal replacement therapy (RRT) at baseline, ≤ 2 serum creatinine values drawn after surgery, and/or if irrigation was the only topical formulation given. The primary outcome was the percentage of patients who developed AKI after intraoperative topical VAN administration. AKI was defined as an increase in serum creatinine (SCr) ≥50% from baseline, an increase in SCr >0.5 from baseline, or0 if RRT was initiated after topical VAN was given. Secondary outcomes included analysis of AKI risk factors and SSI incidence. AKI risk factors were analyzed using a multivariable logistic regression model. Results A total of 589 patient encounters met study criteria. VAN powder was the most common formulation (40.9%), followed by unspecified topical routes (30.7%) and beads (9.9%%). Nonspinal orthopedic surgeries were the most common procedure performed 46.7%. The incidence of AKI was 8.7%. In a multivariable logistic regression model, AKI was associated with concomitant systemic VAN (OR 3.39, [3.39–6.22]) and total topical VAN dose. Each doubling of the topical dose was associated with increased odds of developing AKI (OR = 1.42, [1.08–1.86]). The incidence of SSI was 5.3%. Conclusion AKI rates associated with intraoperative topical VAN are comparable to that of systemic VAN. Total topical vancomycin dose and concomitant systemic VAN was associated with an increased AKI risk. Additional analysis is warranted to compare these patients to a similar population that did not receive topical VAN. Disclosures All authors: No reported disclosures.

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Surgical Thoracoabdominal Aortic Aneurysm Repair in a Non-High-Volume Institution

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0040-1708470 ◽

2020 ◽

Author(s):

Takashi Kunihara ◽

Claudia Vukic ◽

Fumihiro Sata ◽

Hans-Jaochim Schäfers

Keyword(s):

Spinal Cord ◽

Logistic Regression ◽

Aortic Aneurysm ◽

Regression Model ◽

Logistic Regression Model ◽

Thoracoabdominal Aortic Aneurysm ◽

Left Ventricular ◽

Multivariable Logistic Regression Model ◽

Multivariable Logistic Regression ◽

Cord Injury

Abstract Background Surgical thoracoabdominal aortic aneurysm (TAAA) repair remains challenging. Apart from mortality, spinal cord injury (SCI) is a dreaded complication. We analyzed our experience to identify predictors for SCI in a nonhigh-volume institution. Patients and Methods All patients who underwent TAAA repair between February 1996 and November 2016 (n = 182) were enrolled. Most were male (n = 121; 66.4%), median age was 68 years (range: 21–84). Elective operations were performed in 153 instances (84.1%). Our approach to minimize SCI includes distal aortic perfusion, mild hypothermia, identification of the Adamkiewicz artery, and sequential aortic clamping. Cerebrospinal fluid drainage was introduced in 2001 and liberal use of selective visceral perfusion in 2006. Results Early mortality was 12.1%; it was 8.5% after elective procedures. Reduced left ventricular function, nonelective setting, older age, and longer bypass time were identified as independent predictors for mortality in multivariable logistic regression model. Permanent SCI was observed in nine patients (4.9%), of whom seven (3.8%) developed paraplegia. In a multivariable logistic regression model for paraplegia, peripheral arterial disease (PAD), Crawford type II repair, smaller body surface area, and era before 2001 were identified as independent predictors, whereas only PAD was significant for SCI. The incidence of paraplegia was 13.8% in extensive repair out of the first 91 cases, whereas it was improved up to 2.7% thereafter. Conclusion Using an integrated approach, acceptable outcome of TAAA repair can be achieved, even in a nonhigh-volume center. PAD and extensive involvement of the aorta are strong independent predictors for spinal cord deficit after TAAA repair.

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Chronic chiasmal compression and persistent visual field defect without detectable changes in optical coherence tomography of the macular ganglion cell complex

American Journal of Ophthalmology Case Reports ◽

10.1016/j.ajoc.2019.100533 ◽

2019 ◽

Vol 16 ◽

pp. 100533 ◽

Cited By ~ 1

Author(s):

Mark K. Lukewich ◽

Jonathan A. Micieli

Keyword(s):

Optical Coherence Tomography ◽

Visual Field ◽

Ganglion Cell ◽

Visual Field Defect ◽

Cell Complex ◽

Ganglion Cell Complex ◽

Optical Coherence ◽

Chiasmal Compression ◽

Field Defect

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Beyond TILs: Predictors of pathologic complete response (pCR) in triple-negative breast cancer (TNBC) patients with moderate tumor-infiltrating lymphocytes (TIL) receiving neoadjuvant therapy.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.572 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. 572-572

Author(s):

Nour Abuhadra ◽

Kenneth R. Hess ◽

Jennifer Keating Litton ◽

Gaiane M Rauch ◽

Alastair Mark Thompson ◽

...

Keyword(s):

Logistic Regression ◽

Regression Model ◽

Neoadjuvant Therapy ◽

Logistic Regression Model ◽

Stage I ◽

Multivariable Logistic Regression Model ◽

Ki 67 ◽

Early Stage Disease ◽

Cut Points ◽

Multivariable Logistic Regression

572 Background: Increased TIL in TNBC is associated with higher rates of pCR. High TIL is also associated with improved disease free survival and overall survival. The aim of this study is to identify data cut-points of pre-treatment low, moderate and high TIL count based on pCR and to identify clinical and pathological predictors of pCR in patients with moderate TIL. Methods: We evaluated the relationship between pCR and TIL in 180 patients with stage I-III TNBC enrolled in the ARTEMIS trial (NCT02276443). Recursive portioning was used to identify cut-points. Clinical and pathological variables such as age at diagnosis, stage, race, histology as well as Ki-67, vimentin, and androgen receptor (AR) by immunohistochemistry, were evaluated in pts with moderate TIL. A multivariable logistic regression model identified variables independently, significantly associated with pCR. Results: Four TIL groups were identified with pCR rates of 23%, 31%, 48% and 78% respectively (p < 0.0001) (Table A). In the two combined moderate TIL groups, 90 (97%) pts were evaluable for the multivariate model. Stage I-II disease, high Ki-67 and low AR were associated with increased probability of pCR (Table B). The multivariable logistic regression model area under the ROC curve was 0.78 (95% CI=0.68-0.88; p<0.0001). A model of computed risk score [ Stage I-II (score 2)+Ki-67≥ 50% (score 1)+AR<10% (score 1)] predicted a probability of 67% for pCR when all three variables were favorable (Table). Conclusions: Four TIL groups were identified. In pts with moderate TIL levels, early stage disease, high Ki-67 and low AR were associated with increased probability of pCR with neoadjuvant therapy. [Table: see text]

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Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people

International Psychogeriatrics ◽

10.1017/s1041610217000801 ◽

2017 ◽

Vol 29 (9) ◽

pp. 1535-1541 ◽

Cited By ~ 12

Author(s):

Shih-Wei Lai ◽

Cheng-Li Lin ◽

Kuan-Fu Liao

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Logistic Regression ◽

Older People ◽

Regression Model ◽

Logistic Regression Model ◽

Population Based ◽

Multivariable Logistic Regression Model ◽

Retrospective Case ◽

Taiwan National Health Insurance

ABSTRACTBackground:The purpose of this paper was to examine whether glaucoma could be a non-memory manifestation of Alzheimer's disease in older people.Methods:We conducted a population-based, retrospective, case-control study to analyze the database of the Taiwan National Health Insurance Program. There were 1,351 subjects ≥65 years old with newly diagnosed Alzheimer's disease as the cases, and 5,329 subjects without any type of dementias as the controls during 2000–2011. The odds ratio (OR) and 95% confidence interval (CI) for the risk of Alzheimer's disease associated with glaucoma was estimated by the multivariable unconditional logistic regression model.Results:After controlling for confounders, the multivariable logistic regression model demonstrated that the adjusted OR of Alzheimer's disease was 1.50 in subjects with glaucoma (95% CI 1.19, 1.89), compared to subjects without glaucoma.Conclusions:Older people with glaucoma are associated with 1.5-fold increased odds of Alzheimer's disease in Taiwan. Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people. Further research is needed to confirm this issue.

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Rapid screening for influenza using a multivariable logistic regression model to save labor at a clinic in Iwaki, Fukushima, Japan

American Journal of Infection Control ◽

10.1016/j.ajic.2014.01.019 ◽

2014 ◽

Vol 42 (5) ◽

pp. 551-553 ◽

Cited By ~ 2

Author(s):

Vinh Quang Nguyen ◽

Shigeto Abe ◽

Guanghao Sun ◽

Ayumu Matsuoka ◽

Hidekazu Nishimura ◽

...

Keyword(s):

Logistic Regression ◽

Regression Model ◽

Logistic Regression Model ◽

Rapid Screening ◽

Multivariable Logistic Regression Model ◽

Multivariable Logistic Regression

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COVID-19 associated hospitalization in 571 patients with fibromyalgia—A population-based study

PLoS ONE ◽

10.1371/journal.pone.0261772 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0261772

Author(s):

Mor Amital ◽

Niv Ben-Shabat ◽

Howard Amital ◽

Dan Buskila ◽

Arnon D. Cohen ◽

...

Keyword(s):

Logistic Regression ◽

Regression Model ◽

Logistic Regression Model ◽

Multivariable Analysis ◽

Population Based ◽

Female Dominance ◽

Categorical Variables ◽

Continuous Variables ◽

Multivariable Logistic Regression Model ◽

Population Based Study

Objective To identify predicators of patients with fibromyalgia (FM) that are associated with a severe COVID-19 disease course. Methods We utilized the data base of the Clalit Health Services (CHS); the largest public organization in Israel, and extracted data concerning patients with FM. We matched two subjects without FM to each subject with FM by sex and age and geographic location. Baseline characteristics were evaluated by t-test for continuous variables and chi-square for categorical variables. Predictors of COVID-19 associated hospitalization were identified using univariable logistic regression model, significant variables were selected and analyzed by a multivariable logistic regression model. Results The initial cohort comprised 18,598 patients with FM and 36,985 matched controls. The mean age was 57.5± 14.5(SD), with a female dominance of 91%. Out of this cohort we extracted the study population, which included all patients contracted with COVID-19, and consisted of 571 patients with FM and 1008 controls. By multivariable analysis, the following variables were found to predict COVID-19 associated hospitalization in patients with FM: older age (OR, 1.25; CI, 1.13–1.39; p<0.001), male sex (OR, 2.63; CI, 1.18–5.88; p<0.05) and hypertension (OR, 1.75; CI, 1.04–2.95; p<0.05). Conclusion The current population-based study revealed that FM per se was not directly associated with COVID-19 hospitalization or related mortality. Yet classical risk factors endangering the general population were also relevant among patients with FM.

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The risk of flax versus straw bedding on ileal impaction in colic horses: Retrospective analysis of 2336 cases (2008-2017)

Vlaams Diergeneeskundig Tijdschrift ◽

10.21825/vdt.v87i5.16058 ◽

2018 ◽

Vol 87 (5) ◽

pp. 255-262 ◽

Cited By ~ 1

Author(s):

A. Dufourni ◽

A. Decloedt ◽

L. Lefère ◽

D. De Clercq ◽

P. Deprez ◽

...

Keyword(s):

Logistic Regression ◽

Body Weight ◽

Regression Model ◽

Logistic Regression Model ◽

Cox Regression ◽

Conditional Logistic Regression ◽

Large Animal ◽

Multivariable Logistic Regression Model ◽

Multivariable Logistic Regression ◽

Flax Shives

While mature coastal bermudagrass hay is strongly associated with ileal impaction in the Southeastern United States, stabling on flax bedding has anecdotally been associated with this condition in Europe. The aim of this retrospective study was to investigate the association between ileal impaction and the use of flax shives compared to straw as bedding in horses with colic. Medical records of 2336 referral cases evaluated for abdominal pain between January 2008 and May 2017 at the Department of Large Animal Internal Medicine, Ghent University were reviewed. Diagnosis, date of admission, age, breed, gender, body weight and stable bedding were recorded. Conditional logistic regression analysis was used to assess the association between ileal impaction and each individual variable. Odds ratios (OR) and 95% confidence intervals (CI) were determined. Predictors with a value of P < 0.2 were included in a multivariable Cox regression model and Wald’s test was used to assess parameter estimate significance. Further, the association between survival to discharge and type of bedding or type of treatment (medical versus surgical) was analyzed for horses with ileal impactions. The proportion of colic cases stabled on flax bedding at home was 11.3%. The overall prevalence of ileal impaction was 4.2%. In the flax group, the prevalence of ileal impaction was 9.4% as opposed to 3.6% within the straw group. The OR of 2.8 (95% CI 1.7-4.7; P < 0.001) in the multivariable logistic regression model indicated that horses stabled on flax shives were approximately three times more likely to have ileal impactions than horses stabled on straw. There was no significant association found between ileal impaction and the period of admission, age, gender or body weight in a multivariable logistic regression model. The odds for having ileal impaction is approximately six times (OR 6.3; 95% CI 2.4-16.4; P < 0.001) higher in draft horses than in warmbloods in the multivariable logistic regression model. No significant association was found between survival to discharge and type of bedding or treatment. These results suggest that horses with colic that were housed on flax bedding are more likely to present ileal impactions than horses housed on straw.

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