scholarly journals A Meta-Analysis of the Relative Risk of Mortality for Type 1 Diabetes Patients Compared to the General Population: Exploring Temporal Changes in Relative Mortality

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113635 ◽  
Author(s):  
Tom W. C. Lung ◽  
Alison J. Hayes ◽  
William H. Herman ◽  
Lei Si ◽  
Andrew J. Palmer ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Relative Risk ◽  
General Population ◽  
Meta Analysis ◽  
Temporal Changes ◽  
Relative Mortality ◽  
Risk Of Mortality ◽  
Diabetes Patients

scholarly journals PDB20 COST-EFFECTIVENESS OF INSULIN DETEMIR VERSUS NPH FOR TYPE 1 DIABETES PATIENTS IN AN ITALIAN SETTING. A META-ANALYSIS

2007 ◽  
Vol 10 (6) ◽  
pp. A260
Author(s):  
M Aristides ◽  
R Kotchie ◽  
S Nielsen ◽  
M Aagren ◽  
WJ Valentine ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cost Effectiveness ◽  
Insulin Detemir ◽  
Meta Analysis ◽  
Diabetes Patients

scholarly journals Risk of Complications in Children With Type 1 Diabetes and Covid-19

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A62-A62
Author(s):  
Manish Gope Raisingani
Keyword(s):  
Septic Shock ◽  
Type 1 Diabetes ◽  
Relative Risk ◽  
Mortality Rate ◽  
Endotracheal Intubation ◽  
Shock Rate ◽  
P Value ◽  
Intubation Rate ◽  
Risk Of Mortality

Abstract Background: There is some data available in adults which suggests that Type 1 diabetes may be associated with higher risk with Covid-19 (1). Limited data has been available in pediatric Type 1 diabetes with Covid-19. Methods: We used TriNetX, with a large COVID-19 database, collecting real-time electronic medical records data. We compared children (0–18 years) who were diagnosed with Covid-19 with and without Type 1 diabetes. This database collected information from 54 health care organizations. Results: Mortality rate in children with Covid-19 and Type 1 diabetes was 0.618% (10/1618). Mortality rate in children with Covid-19 without Type 1 diabetes was 0.102% (257/251517). Relative risk of mortality for children with Covid-19 and Type 1 diabetes was 6.05 with a p value of < 0.0001. Endotracheal intubation rate in children with Covid-19 and Type 1 diabetes was 0.618% (10/1618). Endotracheal intubation rate in children with Covid-19 without Type 1 diabetes was 0.071% (178/251517). Relative risk of endotracheal intubation for children with Covid-19 and Type 1 diabetes was 8.73 with a p value of < 0.0001. Pneumonia rate in children with Covid-19 and Type 1 diabetes was 0.804% (13/1618). Pneumonia rate in children with Covid-19 without Type 1 diabetes was 0.562% (1414/251517). Relative risk of pneumonia for children with Covid-19 and Type 1 diabetes was 1.43 with a p value of < 0.1959. Septic shock rate in children with Covid-19 and Type 1 diabetes was 1.05% (17/1618). Septic shock rate in children with Covid-19 without Type 1 diabetes was 0.293% (737/251517). Relative risk of septic shock for children with Covid-19 and Type 1 diabetes was 3.59 with a p value of < 0.00001. Conclusion: Mortality rate, endotracheal and septic shock were increased in children with Type 1 diabetes and Covid-19 versus children with Covid-19 and no Type 1 diabetes. Further studies with larger sample size are needed to study complication rate of Covid-19 and Type 1 diabetes. References 1) Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol 2020 Oct;8(10):813–822. doi: 10.1016/S2213-8587(20)30272-2. Epub 2020 Aug 13.

scholarly journals Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

2019 ◽  
Vol 180 (2) ◽  
pp. 135-144 ◽  
Author(s):  
C Nederstigt ◽  
B S Uitbeijerse ◽  
L G M Janssen ◽  
E P M Corssmit ◽  
E J P de Koning ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Random Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Immune Disease ◽  
Statistical Heterogeneity ◽  
Meta Regression ◽  
Diabetes Patients

Introduction The association between type 1 diabetes (T1D) and other auto-immune diseases is well known. However, a quantitative overview of all associated auto-immune diseases and their prevalence in T1D is lacking. Methods We searched PubMed, Web of Science, EMBASE and Cochrane library in September 2018 to identify relevant articles about the prevalence of the following associated auto-immune diseases in T1D cohorts: auto-immune thyroid disease, celiac disease, gastric autoimmunity including pernicious anemia, vitiligo and adrenal gland insufficiency. A meta-analysis was performed to estimate pooled prevalence using a random-effects model. Furthermore, random-effects meta-regression analysis was performed to assess the association between prevalence and mean age or diabetes duration. Results One hundred eighty articles were eligible including a total of 293 889 type 1 diabetes patients. Hypothyroidism (65 studies) was prevalent in 9.8% (95% CI: 7.5–12.3) of patients. Meta-regression showed that for every 10-year age increase, hypothyroidism prevalence increased 4.6% (95% CI: 2.6–6.6, P < 0.000, 54 studies). Weighted prevalence of celiac disease was 4.5% (95% CI: 4.0–5.5, 87 studies). Gastric autoimmunity was found in 4.3% of patients (95% CI: 1.6–8.2, 8 studies) and vitiligo in 2.4% (95% CI: 1.2–3.9, 14 studies) of patients. The prevalence of adrenal insufficiency was 0.2% (95% CI: 0.0–0.4, 14 studies) and hyperthyroidism was found in 1.3 percent (95% CI: 0.9–1.8, 45 studies) of type 1 diabetes patients. For all analyses, statistical heterogeneity between studies was moderate to high. Conclusions The prevalence of antibody-mediated auto-immune disease is high among type 1 diabetes patients. Especially hypothyroidism and celiac disease are frequently found.

scholarly journals Global prevalence of metabolic syndrome among patients with type I diabetes mellitus: a systematic review and meta-analysis

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Rebuma Belete ◽  
Zerihun Ataro ◽  
Ahmedmenewer Abdu ◽  
Merga Sheleme
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
Type I ◽  
Pooled Prevalence ◽  
Diabetes Patients

Abstract Background The presence of metabolic syndrome among diabetes patients is frequent and is associated with an increased incidence of chronic complications and mortality. Despite several studies have been conducted, there is no overall estimation on the prevalence of metabolic syndrome among type 1 diabetic patients. Therefore, this study aimed to estimate the pooled prevalence of metabolic syndrome among patients with type 1 diabetes mellitus. Methods Medline via PubMed, CINAHL, ScienceDirect, Ovid, Google Scholar, ResearchGate and African Journals Online were searched by limiting publication period from January 2005 to October 2020. Data were extracted with a standardized format prepared in Microsoft Excel and exported to Stata 16.0 for analyses. The I2 statistic was used to check heterogeneity across the included studies. DerSimonian and Laird random-effects model was applied to estimate pooled prevalence and 95% confidence interval across studies. Funnel plot symmetry, Begg’s test and Egger’s regression test were used to determine the presence of publication bias. Subgroup and sensitivity analysis as well as meta-regression were conducted to explore the potential sources of heterogeneity. The study protocol is registered on PROSPERO with reference number: CRD42020213435. Results In this meta-analysis, a total of 27 studies with 45,811 study participants were included. The pooled prevalence of metabolic syndrome was 23.7% with substantial heterogeneity (I2 = 98.2%; P < 0.001). Geographical-based subgroup analysis revealed that the highest prevalence was observed in Australia (27.3%). As per meta-analysis of 17 studies, the pooled prevalence of metabolic syndrome in female type 1 diabetes patients (25.9%) was slightly higher than male T1DM patients (22.5%). Conclusion Nearly a quarter of the type 1 diabetes mellitus patients were affected by metabolic syndrome. Therefore, more attention should be paid to the prevention and control of the epidemic and for the reduction of the morbidity and mortality associated with metabolic syndrome among type 1 diabetes mellitus patients.

Prevalence of early and late prematurity is similar among pediatric type 1 diabetes patients and the general population

2018 ◽  
Vol 34 (5) ◽  
pp. e2996 ◽  
Author(s):  
Adi Adar ◽  
Shlomit Shalitin ◽  
Ori Eyal ◽  
Neta Loewenthal ◽  
Orit Pinhas-Hamiel ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
General Population ◽  
Pediatric Type 1 Diabetes ◽  
Diabetes Patients

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Suicide risk in patients with diabetes: a systematic review and meta-analysis

2017 ◽  
Vol 177 (4) ◽  
pp. R169-R181 ◽  
Author(s):  
Bin Wang ◽  
Xiaofei An ◽  
Xiaohong Shi ◽  
Jin-an Zhang
Keyword(s):  
Systematic Review ◽  
Type 1 Diabetes ◽  
Incidence Rate ◽  
Suicide Risk ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
Effective Strategies ◽  
Patients With Diabetes ◽  
Diabetes Patients

Background Previous studies investigating the risk of suicide in diabetes patients reported controversial findings. We did a systematic review and meta-analysis to comprehensively estimate the risk and incidence rate of suicide in diabetic patients. Methods PubMed, EMBASE and PsycINFO were searched for eligible studies. Random-effects meta-analysis was used to calculate the relative risk (RR) and the incidence rate of suicide in diabetes patients. We also calculated the proportion of deaths attributable to suicide among diabetes patients. Results 54 studies were finally included, including 28 studies on the suicide risk associated with diabetes, 47 studies on the incidence rate of suicide and 45 studies on the proportion of deaths attributable to suicide. Meta-analysis showed that diabetes could significantly increase the risk of suicide (RR = 1.56; 95% CI: 1.29–1.89; P < 0.001). Subgroup analysis showed that the RR of suicide associated with type 1 diabetes was 2.25 (95% CI: 1.50–3.38; P < 0.001). The pooled incidence rate of suicide in patients with diabetes was 2.35 per 10 000 person-years (95% CI: 1.51–3.64). The pooled proportions of long-term deaths attributable to suicide in type 1 diabetes patients and type 2 diabetes patients were 7.7% (95% CI: 6.0–9.8) and 1.3% (95% CI: 0.6–2.6), respectively. Conclusion This meta-analysis suggests that diabetes can significantly increase the risk of suicide. Suicide has an obvious contribution to mortality in diabetic patients, especially among type 1 diabetes patients. Effective strategies to decrease suicide risk and improve mental health outcomes in diabetes patients are needed.

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