scholarly journals Jumping Stand Apparatus Reveals Rapidly Specific Age-Related Cognitive Impairments in Mouse Lemur Primates

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0146238 ◽  
Author(s):  
Jean-Luc Picq ◽  
Nicolas Villain ◽  
Charlotte Gary ◽  
Fabien Pifferi ◽  
Marc Dhenain
Keyword(s):  
Cognitive Impairments ◽  
Mouse Lemur ◽  
Age Related

scholarly journals Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation?

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2531
Author(s):  
Amandine Grimm
Keyword(s):  
Brain Metabolism ◽  
Brain Aging ◽  
Cognitive Impairments ◽  
Tau Phosphorylation ◽  
The Body ◽  
Tau Pathology ◽  
Age Related ◽  
Energy Consuming ◽  
Effects Of Aging ◽  
The Brain

The brain is the most energy-consuming organ of the body and impairments in brain energy metabolism will affect neuronal functionality and viability. Brain aging is marked by defects in energetic metabolism. Abnormal tau protein is a hallmark of tauopathies, including Alzheimer’s disease (AD). Pathological tau was shown to induce bioenergetic impairments by affecting mitochondrial function. Although it is now clear that mutations in the tau-coding gene lead to tau pathology, the causes of abnormal tau phosphorylation and aggregation in non-familial tauopathies, such as sporadic AD, remain elusive. Strikingly, both tau pathology and brain hypometabolism correlate with cognitive impairments in AD. The aim of this review is to discuss the link between age-related decrease in brain metabolism and tau pathology. In particular, the following points will be discussed: (i) the common bioenergetic features observed during brain aging and tauopathies; (ii) how age-related bioenergetic defects affect tau pathology; (iii) the influence of lifestyle factors known to modulate brain bioenergetics on tau pathology. The findings compiled here suggest that age-related bioenergetic defects may trigger abnormal tau phosphorylation/aggregation and cognitive impairments after passing a pathological threshold. Understanding the effects of aging on brain metabolism may therefore help to identify disease-modifying strategies against tau-induced neurodegeneration.

Reversal of age-related cognitive impairments in mice by an extremely low dose of tetrahydrocannabinol

2018 ◽  
Vol 61 ◽  
pp. 177-186 ◽  
Author(s):  
Yosef Sarne ◽  
Roni Toledano ◽  
Lital Rachmany ◽  
Effrat Sasson ◽  
Ravid Doron
Keyword(s):  
Low Dose ◽  
Cognitive Impairments ◽  
Age Related

Preventing Alzheimer's Wandering

2019 ◽  
pp. 77-89
Author(s):  
Sara Paiva ◽  
Rui Peleja ◽  
Jorge Cunha ◽  
Carlos Abreu
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quality Of Care ◽  
Cognitive Impairments ◽  
The Elderly ◽  
Strong Impact ◽  
Brain Disorder ◽  
Age Related

With increased life expectancy, the incidence of age-related cognitive impairments, faced by the elderly and older generations, is growing. Among the population with cognitive impairments, those that suffer from Alzheimer's disease are the most common. The Alzheimer's disease is a chronic degenerative brain disorder that is characterised by a failure of memory and, in some instances, by disorders in language, perception and planning. As a consequence of the progressive damages imposed by the illness, patients will increasingly seek and need assistance. This paper presents a tool to aid the development and managing of caregiving communities, comprising immediate family members, relatives, neighbours and healthcare professionals, to assist patients with Alzheimer's disease. Such communities could have a strong impact on the quality of care provided to the patients. At the same time, it is hoped that involving communities will significantly improve the quality of life of Alzheimer's patients and their families while reducing the costs related to the care provided.

Does consciousness matter?

2019 ◽  
pp. 165-188
Author(s):  
Peter Carruthers
Keyword(s):  
Moral Status ◽  
Cognitive Impairments ◽  
Phenomenal Consciousness ◽  
Human Infants ◽  
Age Related ◽  
Moral Status Of Animals

Chapter 7 concluded that there is no fact of the matter concerning phenomenal consciousness in animals, while also arguing that this conclusion is of no importance for science. The present chapter inquires whether it is nevertheless important in other ways, specifically for our ethical treatment of animals, arguing that it is not. But a challenge remains for those who theorize about the moral status of animals: they need to prize the foundations of their theories apart from assumptions about consciousness. The chapter also considers what should be said about the phenomenally conscious status of humans who, like animals, only partially share a full global-broadcasting architecture, such as human infants and people suffering from age-related cognitive impairments.

scholarly journals Age-related cerebral atrophy in nonhuman primates predicts cognitive impairments

2012 ◽  
Vol 33 (6) ◽  
pp. 1096-1109 ◽  
Author(s):  
Jean-Luc Picq ◽  
Fabienne Aujard ◽  
Andreas Volk ◽  
Marc Dhenain
Keyword(s):  
Nonhuman Primates ◽  
Cognitive Impairments ◽  
Cerebral Atrophy ◽  
Age Related

scholarly journals Clinical implications of using questionnaires in elderly men with urinary disorders

2020 ◽  
Vol 8 (4) ◽  
pp. 23-31
Author(s):  
V. A. Dudarev ◽  
V. Yu. Startsev ◽  
E. G. Baksheeva
Keyword(s):  
Clinical Practice ◽  
Cognitive Impairments ◽  
Objective Response ◽  
New Drugs ◽  
Differential Analysis ◽  
Elderly Men ◽  
Symptom Scale ◽  
Symptom Index ◽  
Age Related ◽  
Urinary Tract Symptoms

Introduction. The frequency of lower urinary tract symptoms (LUTS) progression associated with prostatic hyperplasia in elderly men is increasing despite improvements in early diagnosis methods and the emergence of new drugs. Questionnaires are used to assess the patient's condition on primary admission and to monitor the effectiveness of medical procedures to diagnose the severity of LUTS in clinical practice.Purpose of the study. To compare the effectiveness of LUTS diagnosis in elderly men using different scales: the International Prostate Symptom Index (IPSS) and the Visual Prostate Symptom Scale (VPSS) for differential analysis of the cognitive impairment degree.Materials and methods. The study included 56 men, residents of the Trans-Baikal Territory, over the age of 50 with LUTS of varying severity. All patients completed the VPSS and IPSS questionnaires (IPSS1) independently. Subsequently, the IPSS questionnaire (IPSS2) was completed in cooperation with the urologist. Additionally, respondents were questioned using the Montreal Cognitive Assessment Scale (MoCa-test) to determine the degree of dementia and other cognitive impairments.Results. All patients were divided into 3 groups after analyzing the results of the MoCa test: I — patients with signs of dementia, II — with cognitive impairments, III — no cognitive impairments. The predicted differences were obtained when comparing the results of IPSS1 / IPSS2: the greatest differences were in the patients of the first group (76.47%; p < 0.05), the smallest in the third group (12.5%; p > 0.05); there was an increase in the severity of LUTS with self-completion of questionnaires (IPSS1). When evaluating a similar indicator on the VPSS questionnaire, compared with a more objective response with the participation of a physician (IPSS2), statistically significant differences were not obtained in all groups of participants.Conclusion. The dependence of the objectivity of filling out the questionnaires for the diagnosis of LUTS on the severity of cognitive impairments and the age of the respondents was revealed. A reliable correlation of VPSS indicators with the indices of the validated IPSS scale was established. The new questionnaire may be in demand in the clinical practice of a urologist to assess the degree of LUTS in elderly men, as an alternative to the generally accepted IPSS scale, especially in patients with age-related dementia and other cognitive impairments.

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