scholarly journals Potentiation of LPS-Induced Apoptotic Cell Death in Human Hepatoma HepG2 Cells by Aspirin via ROS and Mitochondrial Dysfunction: Protection by N-Acetyl Cysteine

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159750 ◽  
Author(s):  
Haider Raza ◽  
Annie John ◽  
Jasmin Shafarin
Keyword(s):  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Hepg2 Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Hepatoma ◽  
Acetyl Cysteine ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

scholarly journals Flavone Induces Cell Death in Human Hepatoma HepG2 Cells

2014 ◽  
Vol 9 (10) ◽  
pp. 1934578X1400901
Author(s):  
Glaucio Valdameri ◽  
Juliana C. N. Kenski ◽  
Vivian R. Moure ◽  
Marina Trombetta-Lima ◽  
Glaucia R. Martinez ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Hepg2 Cells ◽  
Annexin V ◽  
Future Application ◽  
Mrna Levels ◽  
Human Hepatoma ◽  
Cytochrome C Release ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2

Flavones have received considerable attention because of their antiproliferative properties and selective effects on cancer cells, making them good candidates for use in cancer therapy. In contrast to other flavones, little is known about the effects of the flavone core structure (2-phenyl-4H-1-benzopyran-4one) on cancer cells. Here, we report that flavone induces cell death in human hepatoma HepG2 cells. Furthermore, annexin-V+/PI- and SubG1 populations of HepG2 cells increased after flavone treatment. Exposure of HepG2 to flavone did not result in either cytochrome c release into the cytosol or changes in the mitochondrial membrane potential. Treatment of HepG2 cells with flavone for 24 h reduced the accumulation of intracellular ROS, which correlated with upregulation of Gred, CuZnSOD and MnSOD mRNA levels. Taken together, our results provided useful insights into the mechanism of cell death caused by flavones, in order to evaluate their future application in hepatocarcinoma therapy.

Natural Plant Extract Tubeimoside I Promotes Apoptosis-Mediated Cell Death in Cultured Human Hepatoma (HepG2) Cells

2011 ◽  
Vol 34 (6) ◽  
pp. 831-838 ◽  
Author(s):  
Yashu Wang ◽  
Linhong Deng ◽  
Hongzhe Zhong ◽  
Yajie Wang ◽  
Xuemei Jiang ◽  
...  
Keyword(s):  
Cell Death ◽  
Plant Extract ◽  
Hepg2 Cells ◽  
Human Hepatoma ◽  
Natural Plant ◽  
Human Hepatoma Hepg2 Cells ◽  
Hepatoma Hepg2 ◽  
Tubeimoside I
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