Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0210731 ◽  
Author(s):  
Nicholas Gough ◽  
Jonathan Koffman ◽  
Joy R. Ross ◽  
Julia Riley ◽  
Ian Judson
2006 ◽  
Vol 15 (9) ◽  
pp. 1439-1446 ◽  
Author(s):  
Daphne Schreiber ◽  
Robert S. Bell ◽  
Jay S. Wunder ◽  
Brian O’Sullivan ◽  
Robert Turcotte ◽  
...  

2016 ◽  
Vol 114 (7) ◽  
pp. 821-827 ◽  
Author(s):  
Darin Davidson ◽  
Ronald D. Barr ◽  
Soha Riad ◽  
Anthony M. Griffin ◽  
Peter W. Chung ◽  
...  

2010 ◽  
Vol 13 (7) ◽  
pp. A349
Author(s):  
Y Winter ◽  
F Ringel ◽  
A Spottke ◽  
N Gharevi ◽  
T Klockgether ◽  
...  

2009 ◽  
Vol 21 (6) ◽  
pp. 1171-1179 ◽  
Author(s):  
Sally Wai-chi Chan ◽  
Helen FK Chiu ◽  
Wai-tong Chien ◽  
William Goggins ◽  
David Thompson ◽  
...  

ABSTRACTBackground: Depression is a common psychological problem among older people. Health-related quality of life (HRQoL) is now recognized by healthcare providers as an important treatment goal for people with depression. This study aimed to identify predictors of change in HRQoL among older people with depression.Methods: In a longitudinal study, data were collected when participants were newly diagnosed with a depressive disorder at a regional outpatient department in Hong Kong and 12 months later. Seventy-seven Chinese participants aged 65 years or older completed the study. Measures included the Physical Health Condition Checklist (PHCC), Geriatric Depression Scale (GDS), Modified Barthel Index (MBI), Instrumental Activities of Daily Living (IADL) scale, Social Support Questionnaire (SSQ), and World Health Organization Quality of Life Scale-Brief Version (WHOQOL).Results: Significant improvements between the first and second assessments were noted in the total WHOQOL scores, GDS scores, and the number of the social support. The results of linear regression models showed that the increases in the IADL scores and decreases in the PHCC and GDS scores were significantly associated with higher final WHOQOL scores.Discussion: Treatment for depression was effective in improving the participants’ overall condition and their perceived HRQoL. The results suggest that interventions to alleviate older people's level of depression, manage their physical ill health and enhance their instrumental activities of daily living ability could help improve their perceived HRQoL.


2020 ◽  
Vol 30 (8) ◽  
pp. 1126-1137
Author(s):  
Laila A. Ladak ◽  
Robyn Gallagher ◽  
Babar S. Hasan ◽  
Khadija Awais ◽  
Ahmed Abdullah ◽  
...  

AbstractBackground and objectives:This mixed-methods study aimed to assess health-related quality of life in young adults with CHD following surgery in a low middle-income country, Pakistan. Despite the knowledge that geographic, cultural and socio-economic factors may shape the way health and illness is experienced and managed and consequently determine a person’s health-related quality of life, few health-related quality of life studies are conducted in low middle-income countries. This deficit is pronounced in CHD, so there is little guidance for patient care.Methods:The study utilised concurrent, mixed methods. Adults with CHD (n = 59) completed health-related quality of life surveys (PedsQLTM 4.0 Generic Core Scale, PedsQLTM Cognitive Functioning Scale and PedsQLTM 3.0 Cardiac Module). Semi-structured interview data were collected from a nested sub-sample of 17 participants and analysed using qualitative content analysis, guided by the revised Wilson–Cleary model of health-related quality of life.Results:The lowest health-related quality of life domain was emotional with the mean score (71.61 ± 20.6), followed by physical (78.81 ± 21.18) and heart problem (79.41 ± 18.05). There was no statistical difference in general or cardiac-specific health-related quality of life between mild, moderate or complex CHD. Qualitative findings suggested low health-related quality of life arose from a reduced capacity to contribute to family life including family income and gender. A sense of reduced marriageability and fear of dependency were important socio-cultural considerations.Conclusions:CHD surgical patients in this low-income country experience poor health-related quality of life, and contributing factors differ to those reported for high-income countries. Socio-cultural understandings should underpin assessment, management and care-partnering with young adults with CHD following surgical correction.


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