scholarly journals What factors are associated with the poor prognosis of anal adenocarcinoma compared with low-lying rectal adenocarcinoma based on a population analysis: A propensity score matching study

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0219937
Author(s):  
Qinghua Wang ◽  
Jianfei Fu ◽  
Xiaoxiao Chen ◽  
Cheng Cai ◽  
Hang Ruan ◽  
...  
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Poor Prognosis ◽  
Population Analysis ◽  
Rectal Adenocarcinoma ◽  
Anal Adenocarcinoma ◽  
The Poor

scholarly journals ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma

2020 ◽  
Vol 19 ◽  
pp. 153303382094601
Author(s):  
Hongmei Sun ◽  
Mingying Zhang ◽  
Li Li ◽  
Zongwen Huang
Keyword(s):  
Lung Cancer ◽  
Prognostic Factors ◽  
Propensity Score ◽  
Lung Adenocarcinoma ◽  
Propensity Score Matching ◽  
Aldehyde Dehydrogenase ◽  
Tumor Size ◽  
Poor Prognosis ◽  
Prognostic Biomarker ◽  
The Poor

Background: Lung cancer is the leading cause of cancer-related death, and adenocarcinoma is the most common type of lung cancer. Although emerging evidence implicates the role of several aldehyde dehydrogenases in cancer progression, the expression and clinical significance of aldehyde dehydrogenase 3B1 in lung adenocarcinoma has never been studied. Materials: In our study, the expression of aldehyde dehydrogenase 3B1 in 250 cases of lung adenocarcinoma was detected with immunohistochemistry, and the patients were further divided into subgroups with different aldehyde dehydrogenase 3B1 expression. Using real-time polymerase chain reaction, we investigated the aldehyde dehydrogenase 3B1 messenger RNA in 20 lung adenocarcinoma and paired normal lung tissues. With the χ2 test, we evaluated the clinical significance of aldehyde dehydrogenase 3B1 by analyzing its correlation with the clinicopathological factors. Propensity score matching was performed to balance the baseline of cohort. With univariate and multivariate analyses, we screened the prognostic factors of lung adenocarcinoma and identified the independent prognostic factors before and after the propensity score matching. Results: Aldehyde dehydrogenase 3B1 expression was significantly associated with the sex and age of patients, tumor size, and histological grade. High expression of aldehyde dehydrogenase 3B1 predicted the poor prognosis ( P = .003). Moreover, male patients ( P = .020), large tumor size ( P = .009), advanced T stage ( P = .001), positive lymphatic invasion ( P < .001), and advanced tumor–node–metastasis stage ( P < .001) were all the prognostic factors for unfavorable outcome. Aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma, indicating the poor prognosis. In addition, after balancing the baseline characteristics by propensity score matching, we also demonstrated that aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma ( P = .007). Conclusions: Aldehyde dehydrogenase 3B1 was an independent prognostic biomarker of lung adenocarcinoma, indicating the unfavorable prognosis. Postoperative detection of aldehyde dehydrogenase 3B1 would help stratify the high-risk patients with lung adenocarcinoma and guide individual treatment.

Prognosis of anal canal adenocarcinoma versus lower rectal adenocarcinoma in Japan: a propensity score matching study

Surgery Today ◽  
2021 ◽  
Author(s):  
Yasumitsu Saiki ◽  
Kazutaka Yamada ◽  
Masafumi Tanaka ◽  
Mitsuko Fukunaga ◽  
Yasue Irei ◽  
...  
Keyword(s):  
Propensity Score ◽  
Anal Canal ◽  
Propensity Score Matching ◽  
Rectal Adenocarcinoma

scholarly journals Impact of previous abdominal surgery on robotic-assisted rectal surgery in patients with locally advanced rectal adenocarcinoma: a propensity score matching study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ching-Wen Huang ◽  
Wei-Chih Su ◽  
Tsung-Kun Chang ◽  
Cheng-Jen Ma ◽  
Tzu-Chieh Yin ◽  
...  
Keyword(s):  
Propensity Score ◽  
Abdominal Surgery ◽  
Propensity Score Matching ◽  
Locally Advanced ◽  
Rectal Adenocarcinoma ◽  
Rectal Surgery ◽  
Perioperative Outcomes ◽  
Group Differences ◽  
Robotic Assisted ◽  
Previous Abdominal Surgery

Abstract Background The application of minimally invasive surgery in patients with colorectal cancer (CRC) and a history of previous abdominal surgery (PAS) remains controversial. This retrospective study with propensity score matching (PSM) investigated the impact of PAS on robotic-assisted rectal surgery outcomes in patients with locally advanced rectal adenocarcinoma undergoing preoperative concurrent chemoradiotherapy (CCRT). Methods In total, 203 patients with locally advanced rectal adenocarcinoma who underwent preoperative CCRT and robotic-assisted rectal surgery between May 2013 and December 2019 were enrolled. Patients were categorized into PAS and non-PAS groups based on the PAS history. The PSM caliper matching method with 1-to-3 matches was used to match PAS patients with non-PAS. Results Of the 203 enrolled patients, 35 were PAS patients and 168 were non-PAS patients. After PSM, 32 PAS patients and 96 non-PAS patients were included for analysis. No significant between-group differences were noted in the perioperative outcomes, including median console time (165 min (PAS) vs. 175 min (non-PAS), P = 0.4542) and median operation time (275 min (PAS) vs. 290 min (non-PAS), P = 0.5943) after PSM. Postoperative recovery and overall complication rates were also similar (all P > 0.05). Moreover, the between-group differences in pathological or short-term oncological outcomes were also nonsignificant (all P > 0.05). No 30-day postoperative deaths were observed in either group. Conclusion The current results indicate that robotic-assisted surgery is safe and feasible for PAS patients with locally advanced rectal adenocarcinoma undergoing preoperative CCRT. However, future prospective randomized clinical trials are required to verify these findings.

scholarly journals The Impact of Program Participation on Rural Household Income: Evidence from China’s Whole Village Poverty Alleviation Program

2019 ◽  
Vol 11 (6) ◽  
pp. 1545 ◽  
Author(s):  
Junying Lin ◽  
Zhonggen Zhang ◽  
Lingli Lv
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Household Income ◽  
Poverty Alleviation ◽  
Household Head ◽  
The Political ◽  
Program Participation ◽  
Household Data ◽  
The Poor ◽  
The Impact

Villagers’ participation in poverty alleviation programs has received considerable attention, especially with regard to the poor. However, not much is known about the welfare effect of villagers’ program participation. This paper analyzes the impact of villagers’ program participation on their incomes. We used household data from 529 villagers in China’s Whole Village Poverty Alleviation Program. We focused on two types of program participation—discussion and voting. Using the propensity score matching approach, we estimate the impact of rural households’ program participation on their income. The results show that the education and the political career of the household head determine program participation. Households participating in discussion and voting have a positive and significant effect on household income. Richer households benefit more from the program. However, the poor receive less benefits. We conclude that broadening villager’s participation can boost the effectiveness of China’s poverty alleviation program.

scholarly journals Coagulopathy Induced by Veno-Arterial Extracorporeal Membrane Oxygenation Is Associated With a Poor Outcome in Patients With Out-of-Hospital Cardiac Arrest

2021 ◽  
Vol 8 ◽  
Author(s):  
Takumi Tsuchida ◽  
Takeshi Wada ◽  
Satoshi Gando
Keyword(s):  
Cardiac Arrest ◽  
Propensity Score ◽  
Extracorporeal Membrane Oxygenation ◽  
Prothrombin Time ◽  
Propensity Score Matching ◽  
Poor Prognosis ◽  
Strongly Correlated ◽  
Time Ratio ◽  
Va Ecmo ◽  
Prothrombin Time Ratio

Background: In recent years, the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiopulmonary arrest who do not respond to conventional resuscitation, has increased. However, despite the development of VA-ECMO, the outcomes of resuscitated patients remain poor. The poor prognosis may be attributed to deterioration owing to the post-cardiac arrest syndrome (PCAS); this includes the systemic inflammatory response and coagulation activation caused by the extracorporeal circulation (VA-ECMO circuit) itself. This study aimed to evaluate the coagulofibrinolytic changes caused by VA-ECMO and to identify predictive factors of poor prognosis.Methods: We analyzed 151 cases of PCAS with witnessed cardiac arrest. As biomarkers, platelet counts, prothrombin time ratio, fibrin/fibrinogen degradation products, fibrinogen, antithrombin, and lactate were recorded from blood samples from the time of delivery to the third day of hospitalization. The maximum (max) and minimum (min) values of each factor during the study period were calculated. To evaluate the impact of VA-ECMO on patients with PCAS, we performed propensity score matching between the patients who received and did not receive VA-ECMO. Sub-analysis was performed for the group with VA-ECMO.Results: There were significant differences in all baseline characteristics and demographics except the time from detection to hospital arrival, percentage of cardiopulmonary resuscitations (CPR) by witnesses, and the initial rhythm between the groups. Propensity score matching adjusted for prehospital factors demonstrated that the patients who received VA-ECMO developed significantly severe coagulation disorders. In a sub-analysis, significant differences were noted in the prothrombin time ratio min, fibrinogen max, antithrombin max, and lactate min between survivors and non-survivors. In particular, the prothrombin time ratio min and antithrombin max were strongly correlated with poor outcome.Conclusion: In the present study, significant coagulopathy was observed in patients who received VA-ECMO for CPR. In particular, in patients receiving VA-ECMO, the minimum prothrombin time ratio and maximum antithrombin by day 3 of hospitalization were strongly correlated with poor outcomes. These results suggest that VA-ECMO-induced coagulopathy can be a promising therapeutic target for patients resuscitated by VA-ECMO.

scholarly journals Impact of Previous Abdominal Surgery on Robotic-Assisted Rectal Surgery in Patients with Locally Advanced Rectal Adenocarcinoma: A Propensity Score Matching Study

2020 ◽  
Author(s):  
Ching-Wen Huang ◽  
Wei-Chih Su ◽  
Tsung-Kun Chang ◽  
Cheng-Jen Ma ◽  
Tzu-Chieh Yin ◽  
...  
Keyword(s):  
Propensity Score ◽  
Abdominal Surgery ◽  
Propensity Score Matching ◽  
Locally Advanced ◽  
Rectal Adenocarcinoma ◽  
Rectal Surgery ◽  
Perioperative Outcomes ◽  
Group Differences ◽  
Robotic Assisted ◽  
Previous Abdominal Surgery

Abstract Background: The application of minimally invasive surgery in patients with colorectal cancer (CRC) and a history of previous abdominal surgery (PAS) remains controversial. This retrospective study with propensity score matching (PSM) investigated the impact of PAS on robotic-assisted rectal surgery outcomes in patients with locally advanced rectal adenocarcinoma undergoing preoperative concurrent chemoradiotherapy (CCRT).Methods: In total, 203 patients with locally advanced rectal adenocarcinoma who underwent preoperative CCRT and robotic-assisted rectal surgery between May 2013 and December 2019 were enrolled. Patients were categorized into PAS and non-PAS groups based on the PAS history. The PSM caliper matching method with 1-to-3 match was used to match PAS patients with non-PAS.Results: Of the 203 enrolled patients, 35 were PAS patients 168 were non-PAS patients. After PSM, 32 PAS patients and 96 non-PAS patients were included for analysis. No significant between-group differences were noted in the perioperative outcomes, including median console time [165 min (PAS) vs 175 min (non-PAS), P = 0.4542)] and median operation time [275 min (PAS) vs 290 min (non-PAS), P = 0.5943)] after PSM. Postoperative recovery and overall complication rates were also similar (all P > 0.05). Moreover, the between-group differences in pathological or short-term oncological outcomes were also nonsignificant (all P > 0.05). No 30-day postoperative deaths were observed in either group.Conclusion: The current results indicate that robotic-assisted surgery is safe and feasible for PAS patients with locally advanced rectal adenocarcinoma undergoing preoperative CCRT. However, future prospective randomized clinical trials are required to verify these findings.

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