scholarly journals The long-term consequences of antibiotic therapy: Role of colonic short-chain fatty acids (SCFA) system and intestinal barrier integrity

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0220642 ◽  
Author(s):  
Yuliia Holota ◽  
Taisa Dovbynchuk ◽  
Izumi Kaji ◽  
Igor Vareniuk ◽  
Natalia Dzyubenko ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Antibiotic Therapy ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Barrier Integrity ◽  
Intestinal Barrier Integrity ◽  
Long Term Consequences

scholarly journals Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins

2021 ◽  
Vol 12 ◽  
Author(s):  
Diliana Pérez-Reytor ◽  
Carlos Puebla ◽  
Eduardo Karahanian ◽  
Katherine García
Keyword(s):  
Fatty Acids ◽  
Tight Junction ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Enteric Pathogens ◽  
Short Chain ◽  
Intestinal Lumen ◽  
Barrier Integrity ◽  
Intestinal Barrier Integrity ◽  
Chain Fatty Acids

Short-chain fatty acids (SCFAs) are carboxylic acids produced as a result of gut microbial anaerobic fermentation. They activate signaling cascades, acting as ligands of G-protein-coupled receptors, such as GPR41, GPR43, and GPR109A, that can modulate the inflammatory response and increase the intestinal barrier integrity by enhancing the tight junction proteins functions. These junctions, located in the most apical zone of epithelial cells, control the diffusion of ions, macromolecules, and the entry of microorganisms from the intestinal lumen into the tissues. In this sense, several enteric pathogens secrete diverse toxins that interrupt tight junction impermeability, allowing them to invade the intestinal tissue and to favor gastrointestinal colonization. It has been recently demonstrated that SCFAs inhibit the virulence of different enteric pathogens and have protective effects against bacterial colonization. Here, we present an overview of SCFAs production by gut microbiota and their effects on the recovery of intestinal barrier integrity during infections by microorganisms that affect tight junctions. These properties make them excellent candidates in the treatment of infectious diseases that cause damage to the intestinal epithelium.

The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

2021 ◽  
Vol 165 ◽  
pp. 105420
Author(s):  
Pinyi Liu ◽  
Yanbing Wang ◽  
Ge Yang ◽  
Qihe Zhang ◽  
Lingbin Meng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Intestinal Barrier Function ◽  
Colonic Carcinogenesis ◽  
Chain Fatty Acids

scholarly journals The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-24
Author(s):  
Ana Nogal ◽  
Ana M. Valdes ◽  
Cristina Menni
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Short Chain Fatty Acids ◽  
Metabolic Health ◽  
Short Chain ◽  
Chain Fatty Acids

Emerging role of nutritional short-chain fatty acids (SCFAs) against cancer via modulation of hematopoiesis

2021 ◽  
pp. 1-18
Author(s):  
Muthu Thiruvengadam ◽  
Umadevi Subramanian ◽  
Baskar Venkidasamy ◽  
Prabhu Thirupathi ◽  
Ramkumar Samynathan ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals The role of short chain fatty acids in appetite regulation and energy homeostasis

2015 ◽  
Vol 39 (9) ◽  
pp. 1331-1338 ◽  
Author(s):  
C S Byrne ◽  
E S Chambers ◽  
D J Morrison ◽  
G Frost
Keyword(s):  
Fatty Acids ◽  
Energy Homeostasis ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Appetite Regulation ◽  
Chain Fatty Acids

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

2016 ◽  
Vol 54 (6) ◽  
pp. 4432-4451 ◽  
Author(s):  
Gerwyn Morris ◽  
Michael Berk ◽  
Andre Carvalho ◽  
Javier R. Caso ◽  
Yolanda Sanz ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Microbial Metabolites ◽  
Tryptophan Catabolites ◽  
Chain Fatty Acids

scholarly journals Regulation of energy expenditure and substrate oxidation by short-chain fatty acids

2019 ◽  
Vol 242 (2) ◽  
pp. R1-R8 ◽  
Author(s):  
Alia H Sukkar ◽  
Aaron M Lett ◽  
Gary Frost ◽  
Edward S Chambers
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Weight Gain ◽  
Energy Expenditure ◽  
Lipid Oxidation ◽  
Dietary Fibre ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Present Review

Short-chain fatty acids (SCFAs) are metabolites produced from the fermentation of dietary fibre by the gut microbiota. High-fibre diets have been associated with lower weight gain and a number of reports have therefore investigated if these positive effects of a dietary fibre on body weight can be replicated through the direct administration of SCFAs. Many of these studies have reported that SCFAs can prevent or attenuate long-term body weight gain by increasing energy expenditure through increased lipid oxidation. The aim of the present review is to therefore evaluate the current evidence for an effect of SCFAs on whole-body energy expenditure and to assess the potential underlying mechanisms. The available data highlights that SCFAs can exert multiple effects at various organ and tissue sites that would cumulatively raise energy expenditure via a promotion of lipid oxidation. In conclusion, the present review proposes that dietary interventions and other therapies that augment gut-derived SCFAs and systemic availability may present an effective strategy to improve long-term energy balance and body weight management.

Role of NHE3 in the Maintenance of Intestinal Barrier Integrity in IL-10-Deficient Mice

2011 ◽  
Vol 140 (5) ◽  
pp. S-634-S-635
Author(s):  
Claire B. Larmonier ◽  
Daniel Laubitz ◽  
Alexis L. Bucknam ◽  
Robert D. Thurston ◽  
Faihza M. Hill ◽  
...  
Keyword(s):  
Intestinal Barrier ◽  
Barrier Integrity ◽  
Intestinal Barrier Integrity ◽  
Deficient Mice
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