scholarly journals Maternal diabetes mellitus as an independent risk factor for clinically significant retinopathy of prematurity severity in neonates less than 1500g

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0236639 ◽  
Author(s):  
Chibuzor Nonye Opara ◽  
Mopelola Akintorin ◽  
Allison Byrd ◽  
Natascha Cirignani ◽  
Similolu Akintorin ◽  
...  
2019 ◽  
Vol 8 (1) ◽  
pp. 43-47
Author(s):  
Babita Khanal ◽  
Manoj Kumar Shrivastava ◽  
Prakash Kafle ◽  
Pushpa Kumari Shah

Background: Maternal diabetes mellitus (DM) has been shown to be high risk factor for congenital anomalies. It carries 3-5 times higher risk of incidence compared to the general population. The aims of present study is to investigate and portray the incidence of congenital heart disease in infants of diabetic mothers and know the utility of echocardiography in the early diagnosis of CHD at Nobel Medical College teaching hospital, a tertiary care centre in the eastern part of Nepal and review the current literature. Material & Methods: This is a prospective observational study conducted in Nobel Medical College Teaching hospital, Kanchanbari, Biratnagar Nepal over the period of 12 months. A structured questionnaire was designed which included demographic profile and the Echocardiography findings. The collected data were analysed using window’s SPSS version 20. Results: In the present study of the total deliveries 1.99 % was diabetic mother comprising 208 deliveries.127 had undergone echocardiography in which 10.2 % (n=13) had anomalies. One hundred sixteen were term and 11 were preterm. PDA was the most common anomaly (38.4%) followed by VSD (23.1%) and HCM (15.4%). Conclusion: With the review of current literature it has been found that maternal diabetes mellitus is a significant risk factor for congenital heart disease so it is suggested that the presence of diabetes mellitus in a pregnancy should be taken as a strong suspicious of having CHD and infants should be screened for the same .so as to diagnose the anomaly at the earliest possible.


1994 ◽  
Vol 40 (3) ◽  
pp. 4-6
Author(s):  
K. M. Sergeyeva ◽  
I I Yevsyukova ◽  
T Ye Zayachnikova

Forty-four children of diabetic mothers aged 10.5 years on an average were examined. Ultrasonography and renography with l23I were used to assess these childrens renal status. Various malformations (double kidneys, kidney agenesia, fused of floating kidneys) were detected in 10 patients, in 95 various functional renal disorders were revealed. The authors suppose that maternal juvenile diabetes mellitus, nephropathy, hydramnion, and poor metabolic control during a diabetic pregnancy result in abnormal development of fetal kidneys.


2016 ◽  
Vol 168 ◽  
pp. 201-206 ◽  
Author(s):  
Zuhal Özen Tunay ◽  
Özdemir Özdemir ◽  
Damla Ergintürk Acar ◽  
Derya Öztuna ◽  
Nurdan Uraş

2021 ◽  
Vol 224 (2) ◽  
pp. S188-S189
Author(s):  
Stacey Gold ◽  
Catherine Lopez ◽  
Jessica L. Quistorff ◽  
Sarah Downs ◽  
Sara Iqbal ◽  
...  

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Masanari Kuwabara ◽  
Shigeko Hara ◽  
Koichiro Niwa ◽  
Minoru Ohno ◽  
Ichiro Hisatome

Objectives: Prehypertension frequently progresses to hypertension and is associated with cardiovascular diseases, stroke, excess morbidity and mortality. However, the identical risk factors for developing hypertension from prehypertension are not clarified. This study is conducted to clarify the risks. Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid. We also evaluated whether serum uric acid (hyperuricemia) provided an independent risk for developing hypertension. Results: The cumulative incidence of hypertension from prehypertension over 5 years was 25.3%, but there were no significant differences between women and men (24.4% vs 26.0%, p=0.28). The cumulative incidence of hypertension in subjects with hyperuricemia (n=726) was significantly higher than those without hyperuricemia (n=2,858) (30.7% vs 24.0%, p<0.001). After multivariable adjustments, the risk factors for developing hypertension from prehypertension were age (OR per 1 year increased: 1.023; 95% CI, 1.015-1.032), women (OR versus men: 1.595; 95% CI, 1.269-2.005), higher body mass index (OR per 1 kg/m 2 increased: 1.051; 95% CI 1.021-1.081), higher baseline systolic blood pressure (OR per 1 mmHg increased: 1.072; 95% CI, 1.055-1.089) and diastolic blood pressure (OR per 1 mmHg increased: 1.085; 95% CI, 1.065-1.106), and higher serum uric acid (OR pre 1 mg/dL increased: 1.149; 95% CI, 1.066-1.238), but not smoking and drinking habits, diabetes mellitus, dyslipidemia, and chronic kidney diseases. Conclusions: Increased serum uric acid is an independent risk factor for developing hypertension from prehypertension. Intervention studies are needed to clarify whether the treatments for hyperuricemia in prehypertensive subjects are useful.


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