scholarly journals HDG-select: A novel GUI based application for gene selection and classification in high dimensional datasets

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246039
Author(s):  
Shilan S. Hameed ◽  
Rohayanti Hassan ◽  
Wan Haslina Hassan ◽  
Fahmi F. Muhammadsharif ◽  
Liza Abdul Latiff
Keyword(s):  
Machine Learning ◽  
User Interface ◽  
Graphical User Interface ◽  
Efficient Algorithm ◽  
Gene Selection ◽  
High Dimensional ◽  
Competitive Performance ◽  
User Friendly ◽  
High Dimensional Datasets

The selection and classification of genes is essential for the identification of related genes to a specific disease. Developing a user-friendly application with combined statistical rigor and machine learning functionality to help the biomedical researchers and end users is of great importance. In this work, a novel stand-alone application, which is based on graphical user interface (GUI), is developed to perform the full functionality of gene selection and classification in high dimensional datasets. The so-called HDG-select application is validated on eleven high dimensional datasets of the format CSV and GEO soft. The proposed tool uses the efficient algorithm of combined filter-GBPSO-SVM and it was made freely available to users. It was found that the proposed HDG-select outperformed other tools reported in literature and presented a competitive performance, accessibility, and functionality.

scholarly journals Classification of Brainwaves for Sleep Stages by High-Dimensional FFT Features from EEG Signals

2020 ◽  
Vol 10 (5) ◽  
pp. 1797 ◽  
Author(s):  
Mera Kartika Delimayanti ◽  
Bedy Purnama ◽  
Ngoc Giang Nguyen ◽  
Mohammad Reza Faisal ◽  
Kunti Robiatul Mahmudah ◽  
...  
Keyword(s):  
Machine Learning ◽  
Sleep Stage ◽  
Machine Learning Algorithms ◽  
High Dimensional ◽  
Sleep Stages ◽  
Eeg Signals ◽  
Stage Classification ◽  
Sleep Stage Classification ◽  
Low Dimensional

Manual classification of sleep stage is a time-consuming but necessary step in the diagnosis and treatment of sleep disorders, and its automation has been an area of active study. The previous works have shown that low dimensional fast Fourier transform (FFT) features and many machine learning algorithms have been applied. In this paper, we demonstrate utilization of features extracted from EEG signals via FFT to improve the performance of automated sleep stage classification through machine learning methods. Unlike previous works using FFT, we incorporated thousands of FFT features in order to classify the sleep stages into 2–6 classes. Using the expanded version of Sleep-EDF dataset with 61 recordings, our method outperformed other state-of-the art methods. This result indicates that high dimensional FFT features in combination with a simple feature selection is effective for the improvement of automated sleep stage classification.

Enhanced Backpropagation Approach for Identifying Genetic Disease

2014 ◽  
Vol 622 ◽  
pp. 75-80
Author(s):  
Baskar Nisha ◽  
B. Madasamy ◽  
J.Jebamalar Tamilselvi
Keyword(s):  
Machine Learning ◽  
Genetic Disease ◽  
Classification Accuracy ◽  
Gene Selection ◽  
New Classification ◽  
Backpropagation Algorithm ◽  
High Classification Accuracy ◽  
Disease Associations ◽  
Disease Analysis

Classification of data on genetic disease is a useful application in microarray analysis. The genetic disease data analysis has the potential for discovering the diseased genes which may be the signature of certain diseases. Machine learning methodologies and data mining techniques are used to predict genetic disease associations of bio informatics data. Among numerous existing methods for gene selection, Backpropagation algorithm has become one of the leading methods and it gives less classification accuracy. It aims to develop a new classification algorithm (Enhanced Backpropagation Algorithm) for genetic disease analysis. Knowledge derived by the Enhanced Backpropagation Algorithm has high classification accuracy with the ability to identify the most significant genes.

scholarly journals Methodology Proposal of ADHD Classification of Children Based on Cross Recurrence Plots

2021 ◽  
Author(s):  
Marco Aceves-Fernandez
Keyword(s):  
Machine Learning ◽  
Spectral Distribution ◽  
High Dimensional ◽  
Control Group ◽  
Machine Learning Method ◽  
Learning Method ◽  
Recurrence Plots ◽  
Eeg Signals ◽  
Power Spectral

Abstract Dealing with electroencephalogram signals (EEG) are often not easy. The lack of predicability and complexity of such non-stationary, noisy and high dimensional signals is challenging. Cross Recurrence Plots (CRP) have been used extensively to deal with detecting subtle changes in signals even when the noise is embedded in the signal. In this contribution, a total of 121 children performed visual attention experiments and a proposed methodology using CRP and a Welch Power Spectral Distribution have been used to classify then between those who have ADHD and the control group. Additional tools were presented to determine to which extent the proposed methodology is able to classify accurately and avoid misclassifications, thus demonstrating that this methodology is feasible to classify EEG signals from subjects with ADHD. Lastly, the results were compared with a baseline machine learning method to prove experimentally that this methodology is consistent and the results repeatable.

GEView (Gene Expression View) Tool for Intuitive and High Accessible Visualization of Expression Data for Non-Programmer Biologists

2020 ◽  
pp. 580-592
Author(s):  
Libi Hertzberg ◽  
Assif Yitzhaky ◽  
Metsada Pasmanik-Chor
Keyword(s):  
Gene Expression ◽  
Quality Control ◽  
User Interface ◽  
High Throughput ◽  
Graphical User Interface ◽  
Differential Expression Analysis ◽  
Biological Data ◽  
Expression Data ◽  
Batch Correction ◽  
User Friendly

This article describes how the last decade has been characterized by the production of huge amounts of different types of biological data. Following that, a flood of bioinformatics tools have been published. However, many of these tools are commercial, or require computational skills. In addition, not all tools provide intuitive and highly accessible visualization of the results. The authors have developed GEView (Gene Expression View), which is a free, user-friendly tool harboring several existing algorithms and statistical methods for the analysis of high-throughput gene, microRNA or protein expression data. It can be used to perform basic analysis such as quality control, outlier detection, batch correction and differential expression analysis, through a single intuitive graphical user interface. GEView is unique in its simplicity and highly accessible visualization it provides. Together with its basic and intuitive functionality it allows Bio-Medical scientists with no computational skills to independently analyze and visualize high-throughput data produced in their own labs.

scholarly journals Investigating the role of Simpson’s paradox in the analysis of top-ranked features in high-dimensional bioinformatics datasets

2019 ◽  
Vol 21 (2) ◽  
pp. 421-428 ◽  
Author(s):  
Alex A Freitas
Keyword(s):  
Machine Learning ◽  
High Dimensional ◽  
Feature Ranking ◽  
Ranking Methods ◽  
Simpson’S Paradox ◽  
Small Set ◽  
Simpson's Paradox ◽  
High Dimensional Datasets ◽  
Class Variable

Abstract An important problem in bioinformatics consists of identifying the most important features (or predictors), among a large number of features in a given classification dataset. This problem is often addressed by using a machine learning–based feature ranking method to identify a small set of top-ranked predictors (i.e. the most relevant features for classification). The large number of studies in this area has, however, an important limitation: they ignore the possibility that the top-ranked predictors occur in an instance of Simpson’s paradox, where the positive or negative association between a predictor and a class variable reverses sign upon conditional on each of the values of a third (confounder) variable. In this work, we review and investigate the role of Simpson’s paradox in the analysis of top-ranked predictors in high-dimensional bioinformatics datasets, in order to avoid the potential danger of misinterpreting an association between a predictor and the class variable. We perform computational experiments using four well-known feature ranking methods from the machine learning field and five high-dimensional datasets of ageing-related genes, where the predictors are Gene Ontology terms. The results show that occurrences of Simpson’s paradox involving top-ranked predictors are much more common for one of the feature ranking methods.

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