Psychological features of adult patients with langerhans cell histiocytosis

Background The prevalence of psychological symptoms and the co-occurrence of substance abuse disorders in adult patients with Langerhans cell histiocytosis (LCH) has not been previously explored. We aimed to use validated scales to evaluate depression and anxiety symptoms experienced by adult LCH patients. Methods In this cross-sectional study, all consecutive adult LCH patients seen at our national reference center between January 2012 and January 2013 were asked to complete the following instruments: the Hospital Anxiety and Depression scale (HADS); Barratt Impulsiveness Scale, Version 10 (BIS-10); and Cannabis Use Disorders Identification Test (CUDIT). Self-reported scores on these scales were used to determine the point prevalence of clinically significant psychological symptoms and substance use disorders in LCH patients. Patient profiles in terms of psychological features were assessed by principal component analysis including the HADS and BIS-10 instruments values, followed by hierarchical clustering. Fisher exact tests and Wilcoxon tests were used to examine the associations between disease-related parameters and high levels of anxiety and impulsivity. Results Seventy-one adult LCH patients, mainly with pulmonary LCH (PLCH), completed the evaluations. Clinically significant anxiety and depression symptoms were reported by 22 (31%) and 4 (6%) subjects, respectively. Impulsivity was detected in 14% (10/71) of the patients. Seventeen percent (12/71) of the patients used cannabis on a regular basis, with 50% of these individuals (6/12) exhibiting scores consistent with cannabis use disorder. Three derived clusters of patients were identified in the principal component analysis; these patient clusters differed in successful weaning from tobacco at the time of evaluation (p = 0.03). In univariate analyses, isolated PLCH and the use of psychotropic treatments were statistically associated with clinically significant anxiety symptoms. Conclusions High levels of anxiety and impulsivity are common in adult patients with LCH. The consequences of these symptoms for the management of LCH patients warrant further evaluation.

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Correlation and Principal Component Analysis of Clinical, Bioelectrical and Functional Variables in Newly Diagnosed Lung Cancer Adult Patients

SSRN Electronic Journal ◽

10.2139/ssrn.3882076 ◽

2021 ◽

Author(s):

Justa Carmen Columbié Regüeiferos ◽

Taira Teresa Batista Luna ◽

Soraida Cándida Acosta Brooks ◽

Maylet Planas Rodriguez ◽

Larisa Zamora Matamoros ◽

...

Keyword(s):

Lung Cancer ◽

Principal Component Analysis ◽

Principal Component ◽

Component Analysis ◽

Adult Patients ◽

Newly Diagnosed

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The Mayo Clinic Histiocytosis Working Group Consensus Statement for the Diagnosis and Evaluation of Adult Patients With Histiocytic Neoplasms: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, and Rosai-Dorfman Disease

Mayo Clinic Proceedings ◽

10.1016/j.mayocp.2019.02.023 ◽

2019 ◽

Vol 94 (10) ◽

pp. 2054-2071 ◽

Cited By ~ 16

Author(s):

Gaurav Goyal ◽

Jason R. Young ◽

Matthew J. Koster ◽

W. Oliver Tobin ◽

Robert Vassallo ◽

...

Keyword(s):

Mayo Clinic ◽

Working Group ◽

Langerhans Cell Histiocytosis ◽

Consensus Statement ◽

Langerhans Cell ◽

Adult Patients ◽

Group Consensus ◽

Rosai Dorfman Disease ◽

Erdheim Chester ◽

Chester Disease

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Methotrexate and cytarabine for adult patients with newly diagnosed Langerhans cell histiocytosis: A single arm, single center, prospective phase 2 study

American Journal of Hematology ◽

10.1002/ajh.25864 ◽

2020 ◽

Vol 95 (9) ◽

Cited By ~ 1

Author(s):

Xin‐Xin Cao ◽

Jian Li ◽

Ai‐Lin Zhao ◽

Tian‐Hua He ◽

Xue‐Min Gao ◽

...

Keyword(s):

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Adult Patients ◽

Phase 2 ◽

Newly Diagnosed ◽

Single Center ◽

Phase 2 Study ◽

Prospective Phase

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Psychological abnormalities are commonly present in adult patients with pulmonary Langerhans cell histiocytosis

10.1183/13993003.congress-2019.pa1404 ◽

2019 ◽

Cited By ~ 1

Author(s):

Abdellatif Tazi ◽

Emmanuelle Bugnet ◽

Nishant Gupta ◽

Gwenaël Lorillon ◽

Sayena Arbabzadeh-Bouchez ◽

...

Keyword(s):

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Adult Patients ◽

Pulmonary Langerhans Cell Histiocytosis

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Langerhans cell histiocytosis: oral/periodontal involvement in adult patients

Oral Diseases ◽

10.1111/j.1601-0825.2009.01601.x ◽

2009 ◽

Vol 15 (8) ◽

pp. 596-601 ◽

Cited By ~ 13

Author(s):

S Annibali ◽

MP Cristalli ◽

M Solidani ◽

D Ciavarella ◽

G La Monaca ◽

...

Keyword(s):

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Adult Patients

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Is There an Association between Symptoms of Anxiety and Depression and Quality of Life in Patients with Chronic Obstructive Pulmonary Disease?

Canadian Respiratory Journal ◽

10.1155/2015/478528 ◽

2015 ◽

Vol 22 (1) ◽

pp. 37-41 ◽

Cited By ~ 3

Author(s):

Verônica F Parreira ◽

Renata N Kirkwood ◽

Megan Towns ◽

Isabel Aganon ◽

Lauren Barrett ◽

...

Keyword(s):

Quality Of Life ◽

Chronic Obstructive Pulmonary Disease ◽

Principal Component Analysis ◽

Pulmonary Disease ◽

Principal Component ◽

Component Analysis ◽

Anxiety And Depression ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

BACKGROUND: In addition to symptoms, such as dyspnea and fatigue, patients with chronic obstructive pulmonary disease (COPD) also experience mood disturbances.OBJECTIVE: To explore the relationships between health-related quality of life measures collected from patients with stable COPD and a commonly used measure of depression and anxiety.METHODS: The present analysis was a retrospective study of patients with COPD enrolled in a pulmonary rehabilitation program. Hospital Anxiety and Depression Scale (HADS), Chronic Respiratory Disease Questionnaire (CRQ), Medical Research Council dyspnea scale and 6 min walk test data were collected. Statistical analyses were performed using Spearman’s correlations, and categorical regression and categorical principal component analysis were interpreted using the biplot methodology.RESULTS: HADS anxiety scores retrieved from 80 patients were grouped as ‘no anxiety’ (n=43 [54%]), ‘probable anxiety’ (n=21 [26%]) and ‘presence of anxiety’ (n=16 [20%]). HADS depression scores were similarly grouped. There was a moderate relationship between the anxiety subscale of the HADS and both the emotional function (r=−0.519; P<0.01) and mastery (r=−0.553; P<0.01) domains of the CRQ. Categorical regression showed that the CRQ-mastery domain explained 40% of the total variation in anxiety. A principal component analysis biplot showed that the highest distance between the groups was along the mastery domain, which separated patients without feelings of anxiety from those with anxiety. However, none of the CRQ domains were able to discriminate the three depression groups.CONCLUSIONS: The CRQ-mastery domain may identify symptoms of anxiety in patients with COPD; however, the relationship is not strong enough to use the CRQ-mastery domain as a surrogate measure. None of the CRQ domains were able to discriminate the three depression groups (no depression, probable and presence); therefore, specific, validated tools to identify symptoms of depression should be used.

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Langerhans cell histiocytosis: Differences and similarities in long-term outcome of paediatric and adult patients at a single institutional centre

Hematology ◽

10.1179/1607845414y.0000000173 ◽

2014 ◽

Vol 20 (2) ◽

pp. 83-92 ◽

Cited By ~ 7

Author(s):

Raquel Ciuvalschi Maia ◽

Lídia Maria Magalhães de Rezende ◽

Marcela Robaina ◽

Alexandre Apa ◽

Claudete Esteves Klumb

Keyword(s):

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Adult Patients ◽

Term Outcome ◽

Long Term Outcome

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Histiocitose de Largerhans no Adulto: Experiência de Dois Hospitais Portugueses

Acta Médica Portuguesa ◽

10.20344/amp.5360 ◽

2014 ◽

Vol 27 (6) ◽

pp. 726 ◽

Cited By ~ 1

Author(s):

Margarida Dantas de Brito ◽

Ângelo Martins ◽

Joaquim Andrade ◽

José Guimarães ◽

José Mariz

Keyword(s):

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Adult Patients ◽

Diagnosis Delay ◽

Multisystem Disease ◽

Pulmonary Tissue ◽

Bone Changes ◽

Alive With Disease ◽

The Moment ◽

Clinical Records

Introduction: Langerhans cell histiocytosis is a heterogeneous disease, more frequently diagnosed during childhood. Between 1/2001 and 12/2013, 20 adult patients were admitted at both Hospitals. This work aimed at ccharacterizing this population. Material and Methods: Retrospective study, review of clinical records. Results: 16 patients were eligible to analysis. The median age at diagnosis was 34 years (15-48); 10 males and 6 females. The referral motive was: respiratory complaints – 37.5%; bone changes – 37.5%; dental complaints - 25%; constitutional symptoms - 19%; mucocutaneous lesions – 6% and one patient (6%) was accidentally diagnosed after a thyroidectomy. The tissue of histological diagnosis was: bone - 50%; pulmonary tissue – 37.5%; liver, genital mucosa and thyroid - 6%, respectively. Staging was: single organ involvement (uni/multifocal) - 69% and multisystem disease in 31%. Clinical re-evaluation of these cases is being done at the moment. The median follow up was 5 years (1 month – 11 years) and the overall survival was 92%. Currently 19% are alive without signs of disease; 44% are alive with disease; 25% are under treatment and 12% died. Discussion: These results agree with published literature. Considering the actual guidelines 56% patients were incompletely staged, which probably lead to suboptimal treatment. There is heterogeneity of clinical procedures aiming at staging and treatment of these patients. Conclusion: The diagnosis of adulthood Langerhans cell histiocytosis is difficult considering the diversity of clinical behavior. Frequently this also leads to diagnosis delay. Prospective international clinical trials enrolling adult patients are important. Keywords: Adult; Histiocytosis, Langerhans-Cell.

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Principal component analysis and brain-based predictors of emotion regulation in anxiety and depression

Psychological Medicine ◽

10.1017/s0033291718003148 ◽

2018 ◽

Vol 49 (14) ◽

pp. 2320-2329 ◽

Cited By ~ 1

Author(s):

Heide Klumpp ◽

Kerry L. Kinney ◽

Runa Bhaumik ◽

Jacklynn M. Fitzgerald

Keyword(s):

Principal Component Analysis ◽

Emotion Regulation ◽

Anxiety Disorder ◽

Discriminant Function ◽

Discriminant Function Analysis ◽

Function Analysis ◽

Principal Component ◽

Component Analysis ◽

Anxiety And Depression ◽

Negative Images

AbstractBackgroundReappraisal, an adaptive emotion regulation strategy, is associated with frontal engagement. In internalizing psychopathologies (IPs) such as anxiety and depression frontal activity is atypically reduced suggesting impaired regulation capacity. Yet, successful reappraisal is often demonstrated at the behavioral level. A data-driven approach was used to clarify brain and behavioral relationships in IPs.MethodsDuring functional magnetic resonance imaging, anxious [general anxiety disorder (n = 43), social anxiety disorder (n = 72)] and depressed (n = 47) patients reappraised negative images to reduce negative affect (‘ReappNeg’) and viewed negative images (‘LookNeg’). After each trial, the affective state was reported. A cut-point (i.e. values <0 based on ΔReappNeg-LookNeg) demarcated successful reappraisers. Neural activity for ReappNeg-LookNeg, derived from 37 regions of interest, was submitted to Principal Component Analysis (PCA) to identify unique components of reappraisal-related brain response. PCA factors, symptom severity, and self-reported habitual reappraisal were submitted to discriminant function analysis and linear regression to examine whether these data predicted successful reappraisal (yes/no) and variance in reappraisal ability.ResultsMost patients (63%) were successful reappraisers according to the behavioral criterion (values<0; ΔReappNeg-LookNeg). Discriminant function analysis was not significant for PCA factors, symptoms, or habitual reappraisal. For regression, more activation in a factor with high loadings for frontal regions predicted better reappraisal facility. Results were not significant for other variables.ConclusionsAt the individual level, more activation in a ‘frontal’ factor corresponded with better reappraisal facility. However, neither brain nor behavioral variables classified successful reappraisal (yes/no). Findings suggest individual differences in regions strongly implicated in reappraisal play a role in on-line reappraisal capability.

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