scholarly journals Clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection: A multi-center study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249668
Author(s):  
Shengyang He ◽  
Wenlong Liu ◽  
Mingyan Jiang ◽  
Peng Huang ◽  
Zhi Xiang ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Ground Glass Opacity ◽  
Cell Counting ◽  
Cardiovascular Comorbidities ◽  
Laboratory Results ◽  
Multi Center Study ◽  
Blood Cell Counting ◽  
White Blood Cell Counting

Objective To understand the clinical characteristics of COVID-19 patients with clinically diagnosed bacterial co-infection (CDBC), and therefore contributing to their early identification and prognosis estimation. Method 905 COVID-19 patients from 7 different centers were enrolled. The demography data, clinical manifestations, laboratory results, and treatments were collected accordingly for further analyses. Results Around 9.5% of the enrolled COVID-19 patients were diagnosed with CDBC. Older patients or patients with cardiovascular comorbidities have increased CDBC probability. Increased body temperature, longer fever duration, anhelation, gastrointestinal symptoms, illness severity, intensive care unit attending, ventilation treatment, glucocorticoid therapy, longer hospitalization time are correlated to CDBC. Among laboratory results, increased white blood cell counting (mainly neutrophil), lymphocytopenia, increased procalcitonin, erythrocyte sedimentation rate, C-reaction protein, D-dimer, blood urea nitrogen, lactate dehydrogenase, brain natriuretic peptide, myoglobin, blood sugar and decreased albumin are also observed, indicating multiple system functional damage. Radiology results suggested ground glass opacity mixed with high density effusion opacities and even pleural effusion. Conclusion The aged COVID-19 patients with increased inflammatory indicators, worse lymphopenia and cardiovascular comorbidities are more likely to have clinically diagnosed bacterial co-infection. Moreover, they tend to have severer clinical manifestations and increased probability of multiple system functional damage.

scholarly journals 369. Clinical Characteristics of the First 177 Patients Admitted with COVID-19 at a Bronx Community Hospital

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S254-S254
Author(s):  
Victoria Bengualid ◽  
Maria Martinez ◽  
Zhenisa Hysenaj ◽  
Debra M Willner ◽  
Judith Berger
Keyword(s):  
Oxygen Saturation ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Retrospective Chart Review ◽  
Patient Characteristics ◽  
Altered Mental Status ◽  
Channel Blockers ◽  
First Case ◽  
Overall Mortality

Abstract Background The first case of COVID-19 was admitted on March 15th 2020 to our community based hospital in the Bronx, NY. The aim of this study is to describe the clinical characteristics and outcome of these first COVID-19 patients. Patient Characteristics and Outcome Methods IRB approved retrospective chart review study of all COVID-19 patients admitted during March 2020 focusing on patient characteristics, co-morbidities, clinical manifestations and outcome. Results A total of 177 patients were admitted during March 2020: 57% African American 23.1% Hispanic and 16.9% White. 44.9% female, average age 60 years, and 90% had at least one comorbidity. Outcome was available on all patients except for one who was transferred to another institution for ECMO. Overall mortality was 33%. Clinical presentation: 69.4% presented with cough or shortness of breath, 15.8% with diarrhea, nausea, vomiting or abdominal pain, and 14.6% with myalgia, dizziness or altered mental status. 6.2% presented only with fever. However 59.8% of patients presented with fever and respiratory or gastrointestinal symptoms. Mortality The table compares patients who died vs discharged (either home or to a short term facility). Those that were 65 years or older, hypertensive or presented to the ER with an oxygen saturation of 94% or lower, were more likely to die. Ventilated patients: 31.6% of patients were intubated with a mortality rate of 77%. 22% of these patients were intubated in the first 24 hours. Compared to non-intubated patients, there was no difference in BMI, diabetes, hypertension, COPD/Asthma, use of statins, aspirin or calcium channel blockers. Intubated patients older than 64 years had significantly higher mortality rates (p=0.0001). Conclusion This cohort of COVID-19 patients is unique as almost all received Hydroxychloroquine and Azithromycin. Only 9% received steroids and even fewer received an interleukin-6 inhibitor, convalescent plasma or Remdesivir. African Americans and Hispanics accounted for 80% of patients. Greater than 90% received Medicaid. Overall mortality was 33%. The most common presentation was respiratory followed by gastrointestinal symptoms. The overall mortality was 33% but increased to 77% in intubated patients. Age, hypertension, and ER oxygen saturation correlated with mortality. Disclosures All Authors: No reported disclosures

scholarly journals Retrospective analysis of clinical characteristics of 405 patients with COVID-19

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094903 ◽  
Author(s):  
Ting Zhan ◽  
Meng Liu ◽  
Yalin Tang ◽  
Zheng Han ◽  
Xueting Cheng ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Severe Disease ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Circulatory System ◽  
Respiratory Illnesses ◽  
Reactive Protein ◽  
Circulatory System Diseases ◽  
History Of ◽  
Abnormal Lymphocyte

Objective This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan. Results The patients’ median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels. Conclusion SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.

A rapid high-precision flow cytometry based technique for total white blood cell counting in chickens

2012 ◽  
Vol 145 (1-2) ◽  
pp. 86-99 ◽  
Author(s):  
Christian Seliger ◽  
Beatrice Schaerer ◽  
Marina Kohn ◽  
Helene Pendl ◽  
Steffen Weigend ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Blood Cell ◽  
High Precision ◽  
White Blood Cell ◽  
Cell Counting ◽  
Total White Blood Cell ◽  
Blood Cell Counting ◽  
White Blood Cell Counting

scholarly journals White blood cell counting analysis of blood smear images using various segmentation strategies

2017 ◽  
Author(s):  
Syadia Nabilah Mohd Safuan ◽  
Razali Tomari ◽  
Wan Nurshazwani Wan Zakaria ◽  
Nurmiza Othman
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Blood Smear ◽  
Cell Counting ◽  
Blood Cell Counting ◽  
White Blood Cell Counting

scholarly journals White blood cell counting on smartphone paper electrochemical sensor

2017 ◽  
Vol 90 ◽  
pp. 549-557 ◽  
Author(s):  
Xinhao Wang ◽  
Guohong Lin ◽  
Guangzhe Cui ◽  
Xiangfei Zhou ◽  
Gang Logan Liu
Keyword(s):  
Blood Cell ◽  
Electrochemical Sensor ◽  
White Blood Cell ◽  
Cell Counting ◽  
Blood Cell Counting ◽  
White Blood Cell Counting

Low propidium iodide intensity in flow cytometric white blood cell counting as a marker of cell destruction?

Transfusion ◽  
2005 ◽  
Vol 45 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Thomas Wagner ◽  
Sylvia E. Guber ◽  
Maria-Luise Stubenrauch ◽  
Gerhard Lanzer ◽  
Josef Neumueller
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Propidium Iodide ◽  
Cell Counting ◽  
Cell Destruction ◽  
Flow Cytometric ◽  
Blood Cell Counting ◽  
White Blood Cell Counting

scholarly journals Coronavirus disease 19 with gastrointestinal symptoms as initial manifestations: a case report

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052095225
Author(s):  
Chun-Yang Wu ◽  
Xiao-Pin Yu ◽  
Ada Hoi Yan Ma ◽  
Li-Ping Wang ◽  
Nai-Bin Yang ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Lower Lobe ◽  
Ground Glass Opacity ◽  
Chain Reaction ◽  
Chronic Superficial Gastritis ◽  
Polymerase Chain ◽  
The Right

Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, an epidemic has spread rapidly worldwide. COVID-19 is caused by the highly infectious severe acute respiratory syndrome coronavirus-2. A 42-year-old woman presented to hospital who was suffering from epigastric discomfort and dyspepsia for the past 5 days. Before the onset of symptoms, she was healthy, and had no travel history to Wuhan or contact with laboratory-confirmed COVID-19 cases. An examination showed chronic superficial gastritis with erosion and esophagitis. Enhanced magnetic resonance imaging of the abdomen showed a lesion in the right lower lobe of the lungs. Chest computed tomography showed multiple ground-glass opacity in the lungs. Reverse transcription-polymerase chain reaction was negative for severe acute respiratory syndrome coronavirus-2. There was no improvement after antibiotic treatment. Polymerase chain reaction performed 2 days later was positive and she was diagnosed with COVID-19. After several days of antiviral and symptomatic treatments, her symptoms improved and she was discharged. None of the medical staff were infected. Clinical manifestations of COVID-19 are nonspecific, making differentiating it from other diseases difficult. This case shows the sequence in which symptoms developed in a patient with COVID-19 with gastrointestinal symptoms as initial manifestations.

Sign in / Sign up

Export Citation Format

Share Document