scholarly journals Age-related changes in diffuse optical tomography sensitivity profiles in infancy

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252036
Author(s):  
Xiaoxue Fu ◽  
John E. Richards
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Hemoglobin Concentration ◽  
Separation Distance ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Photon Propagation ◽  
Age Related ◽  
Wide Range

Diffuse optical tomography uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the location that generates the hemodynamic signal requires accurate descriptions of diffuse optical tomography sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development. The present study used photon propagation simulation methods to examine diffuse optical tomography sensitivity profiles in realistic head models among infants ranging from 2 weeks to 24 months with narrow age bins, children (4 and 12 years) and adults (20 to 24 years). The sensitivity profiles changed systematically with the source-detector separation distance. The peak of the sensitivity function in the head was largest at the smallest separation distance and decreased as separation distance increased. The fluence value dissipated more quickly with sampling depth at the shorter source-detector separations than the longer separation distances. There were age-related differences in the shape and variance of sensitivity profiles across a wide range of source-detector separation distances. Our findings have important implications in the design of sensor placement and diffuse optical tomography image reconstruction in (functional) near-infrared light spectroscopy research. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone near-infrared light spectroscopy data in infants.

scholarly journals Investigating Developmental Changes in Scalp-Cortex Correspondence Using Diffuse Optical Tomography Sensitivity in Infancy

2020 ◽  
Author(s):  
Xiaoxue Fu ◽  
John E. Richards
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Hemoglobin Concentration ◽  
Infrared Light ◽  
Photon Propagation ◽  
Age Related ◽  
Age Appropriate ◽  
Pediatric Populations ◽  
Cortical Regions

AbstractSignificanceDiffuse optical tomography (DOT) uses near-infrared light spectroscopy (NIRS) to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of NIRS data requires accurate descriptions of the cranio-cerebral relations and DOT sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development.AimThe present study aimed to investigate age-related differences in scalp-to-cortex distance and mapping between scalp locations and cortical regions of interest (ROIs) among infants (2 weeks to 24 months with narrow age bins), children (4 and 12 years) and adults (20 to 24 years).ApproachWe used spatial scalp projection and photon propagation simulation methods with age-matched realistic head models based on MRIs.ResultsThere were age-group differences in the scalp-to-cortex distances in infancy. The developmental increase was magnified in children and adults. There were systematic age-related differences in the probabilistic mappings between scalp locations and cortical ROIs.ConclusionsOur findings have important implications in the design of sensor placement and making anatomical interpretations in NIRS and fNIRS research. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone DOT data in infants.

scholarly journals Near-infrared-light-induced decomposition of Rhodamine B triggered by localized surface plasmon at gold square dimers with well-defined separation distance

AIP Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 035153 ◽  
Author(s):  
Satoshi Kaneko ◽  
Shuhei Watanabe ◽  
Shinya Kasai ◽  
Tomoaki Nishino ◽  
Kazuhito Tsukagoshi ◽  
...  
Keyword(s):  
Surface Plasmon ◽  
Rhodamine B ◽  
Near Infrared ◽  
Separation Distance ◽  
Infrared Light ◽  
Localized Surface Plasmon ◽  
Near Infrared Light ◽  
Induced Decomposition

Modeling the Near Infrared Light Propagation in Biological Tissues

2015 ◽  
Vol 713-715 ◽  
pp. 686-689
Author(s):  
Yu Xiang Wu ◽  
Min Fang Huang ◽  
Tao Song ◽  
Guo Dong Xu
Keyword(s):  
Biological Tissue ◽  
Light Propagation ◽  
Near Infrared ◽  
Structural Characteristics ◽  
Biological Tissues ◽  
Infrared Light ◽  
Optical Parameters ◽  
Near Infrared Light ◽  
Photon Propagation ◽  
Transmission And Distribution

The model of photon energy distribution in biological tissue has a very important significance in the diagnosis and treatment of biomedical area. The history and development of optical transmission and distribution in the biological tissue is outlined. The structural characteristics and optical properties of biological tissue are explained and discussed. To demonstrate the model of photon propagation in biological tissue, several methods about laser and biological tissue interaction of transmission theory are summarized and the physical meaning of the tissue optical parameters on is considered. On this basis, we simulated near infrared light distribution of the biological tissue with Monte Carlo methods and obtained meaningful results.

The Value of Photo Biological Regulation Based on Nano Semiconductor Laser Technology in the Treatment of Hypertension Fundus Disease

2021 ◽  
Vol 21 (2) ◽  
pp. 1323-1330
Author(s):  
Xingui Hu ◽  
Linan Zhou ◽  
Huifeng Wang ◽  
Yuanpeng Gao ◽  
Yan Gao
Keyword(s):  
Semiconductor Laser ◽  
Near Infrared ◽  
Theoretical Data ◽  
Low Energy ◽  
Infrared Light ◽  
Tissue Blood Flow ◽  
Near Infrared Light ◽  
Biological Regulation ◽  
Laser Technology ◽  
Wide Range

With the development of nanometer semiconductor laser technology, due to the wide range of photobiological regulation and non-invasive advantages, it is widely used in clinical research, including reducing pain, accelerating wound healing, nerve injury repair and regeneration. Increase tissue blood flow, improve anxiety and depression, and treat Parkinson’s and retinal diseases. However, in many studies, the role of photobiological regulation is still controversial. There are two main problems, one is that the mechanism of photo biological regulation is not fully understood, and the other is that the specific parameters are not uniform in different treatments, such as wavelength density, power density, pulse, treatment timing, and number of treatments. In this paper, through the second question, the parameters of low-energy near-infrared light (810 nm semiconductor laser) in the treatment of fundus diseases are the main research objects. Based on understanding the parameters of low-energy lasers, cyan blue is irradiated with different energy near-infrared light. Data analysis of the actual energy obtained after the retina of the rabbit and observation and research on the cell morphology of each layer of the retina, to obtain relatively safe treatment parameters for the retina, provide theoretical data for near-infrared light in the treatment of clinical fundus disease, and make it safer to use in clinical treatment.

A Nano-Gap Nano-Antenna for Enhancing the Spatial Resolution of Optical Brain Imaging

2020 ◽  
Vol 15 (1) ◽  
pp. 24-31
Author(s):  
Zeshan Shoaib ◽  
Junhyun Kim ◽  
M. Ahmad Kamran ◽  
Myung Yung Jeong
Keyword(s):  
Brain Imaging ◽  
Spatial Resolution ◽  
Biomedical Imaging ◽  
Near Infrared ◽  
Low Cost ◽  
Resolution Enhancement ◽  
Separation Distance ◽  
Imaging Systems ◽  
Infrared Light ◽  
Near Infrared Light

Optical brain imaging has the potential for a bright future thanks to its low cost and portability relative to other biomedical imaging modalities. Temporal and spatial resolutions are considered to be the discriminatory features for selection of biomedical imaging equipment. Optical brain imaging systems, however, still face the bottleneck of limited spatial resolution. In this study, a novel method for guiding near infrared light at one of two particular gaps spaced nanometers apart has been presented. It includes the design of a nanogap nano-antenna for measurement of overlapping information on vicinities of only nanoscale separation distance, which could result in enhancement of the spatial resolution of optical brain imaging systems. The design of the proposed nano-gap nano-antenna channels near-infrared light to a specific path among two gaps separated by a nanometer-scale distance. A supportive analysis of gap design also is presented in this study. Additionally, the results of a comprehensive analysis of the behavior of light through the designed nano-gap nano-antenna are provided. The proposed methodology is a practical substitute for a high-density probe arrangement as well as a possible means of spatial resolution enhancement.

An ordered copper nanowell-array film with near-perfect broadband absorption from ultraviolet to near-infrared light

2020 ◽  
Vol 59 (11) ◽  
pp. 110906
Author(s):  
Juan Shen ◽  
Yong Ren ◽  
Xinxin Zhu ◽  
Min Mao ◽  
Quan Zhou ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Broadband Absorption

scholarly journals Recent Near-Infrared Light-Activated Nanomedicine toward Precision Cancer Therapy

2021 ◽  
Author(s):  
Xiaowei Luan ◽  
Yongchun Pan ◽  
Yanfeng Gao ◽  
Yujun Song
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Human Society ◽  
Near Infrared Light ◽  
History Of ◽  
The Universe

Light has witnessed the history of mankind and even the universe. It is of great significances to the life of human society, contributing to energy, agriculture, communication, and much more....

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