Association between body composite indices and vertebral fractures in pre and postmenopausal women in Korea

The association between obesity and vertebral fracture remains controversial. This study aimed to investigate the association between obesity/abdominal obesity and vertebral fracture according to menopausal status. This nationwide population-based epidemiologic study collected data from the Korean National Health Insurance Services to investigate the association between obesity/abdominal obesity and vertebral fracture in pre and postmenopausal women who underwent national cancer screening in 2009. We used three body composite indices of obesity, body mass index, waist circumference and waist-to-height ratio, to classify participants into obesity and abdominal obesity groups. In both pre and postmenopausal groups, participants with obesity showed a higher risk of vertebral fracture and the association was stronger in those with abdominal obesity (p < 0.001). Participants with obesity showed a high risk of vertebral fracture, and the association was stronger in participants with abdominal obesity (p < 0.001). In both pre and postmenopausal groups, participants with obesity showed a higher risk of vertebral fracture (adjusted HR, 1.24; 95% CI, 1.19–1.30), (adjusted HR, 1.04; 95% CI, 1.03–1.05, and those with abdominal obesity showed even higher risk of vertebral fractures (adjusted HR, 1.35; 95% CI, 1.27–1.43), (adjusted HR, 1.13; 95% CI, 1.11–1.14). Vertebral fracture risk is higher in pre and postmenopausal women with obesity and even higher in those with abdominal obesity. Therefore, weight management can prevent vertebral fractures.

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Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study

Osteoporosis International ◽

10.1007/s00198-014-2628-2 ◽

2014 ◽

Cited By ~ 2

Author(s):

E. Kanterewicz ◽

◽

E. Puigoriol ◽

J. García-Barrionuevo ◽

L. del Rio ◽

...

Keyword(s):

Vertebral Fracture ◽

Postmenopausal Women ◽

Vertebral Fractures ◽

Population Based ◽

Vertebral Fracture Assessment ◽

Population Based Study ◽

Vertebral Deformities ◽

Fracture Assessment

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Calciotropic Hormones and the Prevalence of Vertebral Fractures in Chinese Postmenopausal Women with Vitamin D Insufficiency: Peking Vertebral Fracture Study

Calcified Tissue International ◽

10.1007/s00223-019-00531-2 ◽

2019 ◽

Vol 104 (6) ◽

pp. 622-630

Author(s):

Ruizhi Jiajue ◽

Yan Jiang ◽

Xuan Qi ◽

Qiuping Wang ◽

Wenbo Wang ◽

...

Keyword(s):

Vitamin D ◽

Vertebral Fracture ◽

Postmenopausal Women ◽

Vertebral Fractures ◽

Vitamin D Insufficiency ◽

Calciotropic Hormones ◽

Chinese Postmenopausal Women ◽

Fracture Study

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Identification of prevalent vertebral fractures using Vertebral Fracture Assessment (VFA) in asymptomatic postmenopausal women: A systematic review and meta-analysis

Bone ◽

10.1016/j.bone.2020.115358 ◽

2020 ◽

Vol 136 ◽

pp. 115358

Author(s):

Jingyan Yang ◽

Yushan Mao ◽

Jeri W. Nieves

Keyword(s):

Systematic Review ◽

Vertebral Fracture ◽

Postmenopausal Women ◽

Vertebral Fractures ◽

Meta Analysis ◽

Vertebral Fracture Assessment ◽

Fracture Assessment

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The population-based prevalence of osteoporotic vertebral fracture and densitometric osteoporosis in postmenopausal women over 50 in Valencia, Spain (the FRAVO Study)

Bone ◽

10.1016/j.bone.2010.06.015 ◽

2010 ◽

Vol 47 (3) ◽

pp. 610-616 ◽

Cited By ~ 40

Author(s):

José Sanfélix-Genovés ◽

Begoña Reig-Molla ◽

Gabriel Sanfélix-Gimeno ◽

Salvador Peiró ◽

Magdalena Graells-Ferrer ◽

...

Keyword(s):

Vertebral Fracture ◽

Postmenopausal Women ◽

Population Based ◽

Osteoporotic Vertebral Fracture

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Are the factors associated with overweight/general obesity and abdominal obesity different depending on menopausal status?

PLoS ONE ◽

10.1371/journal.pone.0245150 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0245150

Author(s):

Jyu-Lin Chen ◽

Jia Guo ◽

Ping Mao ◽

Jundi Yang ◽

Shan Jiang ◽

...

Keyword(s):

Physical Activity ◽

Postmenopausal Women ◽

Psychosocial Factors ◽

Abdominal Obesity ◽

Rural Women ◽

Menopausal Status ◽

Well Being ◽

General Obesity ◽

Factors Associated ◽

The Impact

Rapid modernization in China has impacted the daily lives and health of women, including a rise in obesity. However, little is known about the impact of menopausal status, behavior, and psychosocial factors on the risk of obesity for rural women in China. The aim of this study is to identify risk factors, including demographic information (education, family history of T2DM, menopausal status), obesity-related behavior, and psychosocial factors associated with overweight/general obesity and abdominal obesity. In a cross-sectional study design, participants had their weight, height, and waist circumference measured and completed questionnaires regarding family demographics, obesity-related health behaviors (physical activity, diet, sleep), and psychosocial information (stress, social support, and self-efficacy related to physical activity and healthy diet). A total of 646 women were included in this study; 46.6% were overweight/generally obese, and 48% had abdominal obesity. Postmenopausal women had a higher prevalence of general and central obesity. Regular physical activity decreased the risk for overweight/general obesity and abdominal obesity (OR = .41 and .31, respectively, p = .04) in premenopausal women. Postmenopausal women who had not breastfed their infants and reported moderate/high-stress had a higher risk for overweight/general obesity (OR = 3.93, and 2, respectively) and those who reported less than 6 hours of sleep per day increased their risk for abdominal obesity (OR = 2.08). Different factors associated with obesity were found in Chinese women, depending on menopausal status. Future studies should examine the impact of menopause on a woman’s risk for obesity, as well as develop tailored interventions to improve health, well-being and reduce the risk of obesity.

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VERTEBRAL AND PERIPHERAL FRACTURES: DIAGNOSTIC TOOLS AND MEDICO-SOCIAL SIGNIFICANCE

Traumatology and Orthopedics of Russia ◽

10.21823/2311-2905-2010-0-2-106-109 ◽

2010 ◽

Vol 16 (2) ◽

pp. 106-109

Author(s):

E. G. Zotkin ◽

O. G. Khurtsilava ◽

I. I. Zubkova ◽

Yu. A. Safonova

Keyword(s):

Vertebral Fractures ◽

Epidemiologic Study ◽

Population Based ◽

Diagnostic Tools ◽

Social Significance ◽

Early Administration ◽

Population Based Study ◽

Minimal Trauma ◽

European Vertebral Osteoporosis Study ◽

Clinical Fractures

Medico-social significance of osteoporosis is determined by the high frequency of low-traumatic fractures of bone. According to the European Vertebral Osteoporosis Study the prevalence of vertebral fractures was 11,5% in women of 50-54 years of age and reached 34.8% in women of 75-79. The only prospective population-based study conducted in Russia have showed that the incidence of new vertebral fractures was 5,9% in men and 9,9% in women over 50. Stratified epidemiologic study conducted in St. Petersburg, have showed that in men the peak of clinical fractures, developed with minimal trauma, was at the age of 20-24 and 65-69. In women the peak of fractures was determined at the ages 50-54 years. It has been suggested that early administration of antiosteoporotic drugs can effectively prevent vertebral and peripheral fractures.

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Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgz162 ◽

2019 ◽

Vol 105 (3) ◽

pp. 938-943 ◽

Cited By ~ 2

Author(s):

Benjamin Z Leder ◽

Bruce Mitlak ◽

Ming-yi Hu ◽

Gary Hattersley ◽

Richard S Bockman

Keyword(s):

Vertebral Fracture ◽

Fracture Risk ◽

Postmenopausal Women ◽

Risk Reduction ◽

Vertebral Fractures ◽

Statistical Significance ◽

Fracture Rate ◽

Alendronate Treatment ◽

Clinical Fractures ◽

Fracture Risk Reduction

Abstract Context The ACTIVE study demonstrated the antifracture efficacy of abaloparatide in postmenopausal women with osteoporosis. ACTIVExtend demonstrated sustained fracture risk reduction with alendronate in abaloparatide-treated participants from ACTIVE. A direct comparison of the efficacy of abaloparatide and antiresorptive therapies has not been performed. Objective The objective of this analysis is to compare the antifracture efficacy of abaloparatide in ACTIVE with that of alendronate in ACTIVExtend. Design In this post hoc analysis, the rate of new vertebral fractures for women in ACTIVExtend (N = 1139) was calculated based on baseline and endpoint radiographs for placebo or abaloparatide in ACTIVE and alendronate in ACTIVExtend. Vertebral fracture rates between abaloparatide and alendronate were compared in a Poisson regression model. Fracture rates for nonvertebral and clinical fractures were compared based on a Poisson model during 18 months of abaloparatide or placebo treatment in ACTIVE and 18 months of alendronate treatment in ACTIVExtend. Results The vertebral fracture rate was lower during abaloparatide treatment in ACTIVE (0.47 fractures/100 patient-years) than alendronate treatment in ACTIVExtend (1.66 fractures/100 patient-years) (relative risk reduction 71%; P = .027). Although the comparisons did not meet statistical significance, after switching from placebo (ACTIVE) to alendronate (ACTIVExtend), the rate of new vertebral fractures decreased from 2.49 to 1.66 fractures per 100 patient-years, and after switching from abaloparatide to alendronate from 0.47 to 0.19 fractures per 100 patient-years. The rates of nonvertebral fractures and clinical fractures were not significantly different. Conclusion Initial treatment with abaloparatide may result in greater vertebral fracture reduction compared with alendronate in postmenopausal women with osteoporosis.

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