APPLICATION OF LUNG PROTECTIVE MECHANICAL VENTILATION (USING LOWER TIDAL VOLUMES) MANDATES THE USE OF PREDICTED BODY WEIGHT INSTEAD OF ACTUAL BODY WEIGHT

CHEST Journal ◽  
2005 ◽  
Vol 128 (4) ◽  
pp. 227S
Author(s):  
Esther K. Wolthuis ◽  
Rogier M. Determann ◽  
Marcus J. Schultz
Keyword(s):  
Mechanical Ventilation ◽  
Body Weight ◽  
Actual Body ◽  
Actual Body Weight ◽  
Predicted Body Weight ◽  
Protective Mechanical Ventilation ◽  
Lung Protective Mechanical Ventilation

A review of intraoperative lung-protective mechanical ventilation strategy

2020 ◽  
Author(s):  
Trung kien Nguyen ◽  
Duc Hanh Mai ◽  
Anh Nguyet Le ◽  
Quang Huy Nguyen ◽  
Chi Tue Nguyen ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Ventilation Strategy ◽  
Protective Mechanical Ventilation ◽  
Lung Protective Mechanical Ventilation

scholarly journals Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Thiago G. Bassi ◽  
Elizabeth C. Rohrs ◽  
Karl C. Fernandez ◽  
Marlena Ornowska ◽  
Michelle Nicholas ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Brain Injury ◽  
Neuronal Damage ◽  
Normal Lung ◽  
Preclinical Model ◽  
Negative Consequences ◽  
Mechanically Ventilated ◽  
Protective Mechanical Ventilation ◽  
Hippocampal Apoptosis ◽  
Lung Protective Mechanical Ventilation

AbstractMechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. Markers in the serum for astrocyte damage and neuronal damage were also higher in the mechanically ventilated group. Therefore, our study demonstrated that considerable hippocampal insult can be observed after 50 h of lung-protective mechanical ventilation, sedation and physical immobility.

Adjusted versus actual body weight dosing of 4-factor prothrombin complex concentrate in obese patients with warfarin-associated major bleeding

2018 ◽  
Vol 47 (3) ◽  
pp. 369-374 ◽  
Author(s):  
Keaton S. Smetana ◽  
Rachel Ziemba ◽  
Casey C. May ◽  
Michael J. Erdman ◽  
Edward T. Van Matre ◽  
...  
Keyword(s):  
Body Weight ◽  
Actual Body ◽  
Major Bleeding ◽  
Prothrombin Complex Concentrate ◽  
Obese Patients ◽  
Actual Body Weight

Effects of Feedback and Education on Nurses’ Clinical Competence in Mechanical Ventilation and Accurate Tidal Volume Setting

2021 ◽  
Author(s):  
Samira Norouzrajabi ◽  
Shahrzad Ghiyasvandian ◽  
Alireza Jeddian ◽  
Ali Karimi Rozveh ◽  
Leila Sayadi
Keyword(s):  
Mechanical Ventilation ◽  
Body Weight ◽  
Tidal Volume ◽  
Clinical Competence ◽  
High Tidal Volume ◽  
Education Intervention ◽  
Predicted Body Weight ◽  
Post Test ◽  
The Mean ◽  
Effects Of Feedback

Background: Patients under mechanical ventilation are at risk of ventilator-associated complications. One of these complications is lung injury due to high tidal volume. Nurses’ competence in mechanical ventilation is critical for preventing ventilator-associated complications. This study assessed the effects of feedback and education on nurses’ clinical competence in mechanical ventilation and accurate tidal volume setting. Methods: This single arm pretest-post-test interventional study was conducted in 2019 at Shariati hospital affiliated to Tehran University of Medical Sciences. Participants were 75 conveniently selected nurses. Initially, nurses’ clinical competence in mechanical ventilation and ventilator parameters of 250 patients were assessed. A mechanical ventilation -based feedback and education intervention was implemented for nurses. Finally, mechanical ventilation clinical competence of nurses and ventilator parameters of 250 new patients were assessed. Moreover, patients’ height was estimated based on their ulna length and then, their predicted body weight was calculated using their estimated height. Accurate tidal volume was determined per predicted body weight.  Results: The mean score of nurses’ clinical competence increased from 8.27±3.09 at pretest to 10.07±3.34 at post-test (p<0.001). The mean values of both total tidal volume and tidal volume per kilogram of predicted body weight were significantly reduced respectively from 529.84±69.11 and 9.11±1.73 (ml) at pretest to 476.30±31.01 and 7.79±1.14 (ml) at post-test (p<0.001). Conclusion: The feedback and education intervention is effective in promoting nurses’ clinical competence in mechanical ventilation and reducing tidal volume. Thereby, it can reduce lung injuries associated with high tidal volume and ensure patient safety.

scholarly journals Actual body weight-based vancomycin dosing in neonates

2019 ◽  
Vol 31 (6) ◽  
pp. 307-312 ◽  
Author(s):  
Pavla Pokorná ◽  
Martin Šíma ◽  
Olga Černá ◽  
Karel Allegaert ◽  
Dick Tibboel ◽  
...  
Keyword(s):  
Body Weight ◽  
Actual Body ◽  
Actual Body Weight

Unfractionated heparin infusion for treatment of venous thromboembolism based on actual body weight without dose capping

2019 ◽  
Vol 25 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Julia A Shlensky ◽  
Kristina M Thurber ◽  
John G O’Meara ◽  
Narith N Ou ◽  
Jennifer L Osborn ◽  
...  
Keyword(s):  
Body Weight ◽  
Venous Thromboembolism ◽  
Actual Body ◽  
Unfractionated Heparin ◽  
Obese Group ◽  
Morbidly Obese ◽  
Actual Body Weight ◽  
Bleeding Events ◽  
Heparin Infusion ◽  
Significant Difference

Controversy exists regarding the use of dose capping of weight-based unfractionated heparin (UFH) infusions in obese and morbidly obese patients. The primary objective of this study was to compare time to first therapeutic activated partial thromboplastin time (aPTT) in hospitalized patients receiving UFH for acute venous thromboembolism (VTE) among three body mass index (BMI) cohorts: non-obese (< 30 kg/m2), obese (30–39.9 kg/m2), and morbidly obese (⩾ 40 kg/m2). In this single-center, retrospective cohort study, patients were included if they ⩾ 18 years of age, had a documented VTE, and were on an infusion of UFH for at least 24 hours. Weight-based UFH doses were calculated using actual body weight. A total of 423 patients met the inclusion criteria, with 230 (54.4%), 146 (34.5%), and 47 (11.1%) patients in the non-obese, obese, and morbidly obese cohorts, respectively. Median times to therapeutic aPTT were 16.4, 16.6, and 17.1 hours in each cohort. Within 24 hours, the cumulative incidence rates for therapeutic aPTT were 70.7% for the non-obese group, 69.9% for the obese group, and 61.7% for the morbidly obese group (obese vs non-obese: HR = 1.02, 95% CI: 0.82–1.26, p = 0.88; morbidly obese vs non-obese: HR = 0.87, 95% CI: 0.62–1.21, p = 0.41). There was no significant difference in major bleeding events between BMI groups (obese vs non-obese, p = 0.91; morbidly obese vs non-obese, p = 0.98). Based on our study, heparin dosing based on actual body weight without a dose cap is safe and effective.

The growth of lambs before and after birth in relation to the level of nutrition

1948 ◽  
Vol 38 (3) ◽  
pp. 243-302 ◽  
Author(s):  
L. R. Wallace
Keyword(s):  
Body Weight ◽  
Actual Body ◽  
Growth Curves ◽  
Live Weight ◽  
Constant Level ◽  
Gravid Uterus ◽  
Standard Diet ◽  
Actual Body Weight ◽  
Weight Growth ◽  
Before And After

SUMMARYIn the investigation described, we have observed a t monthly intervals throughout gestation the changes taking place in a series of similar ewes, in lamb to the same ram, and each receiving the same standard diet.In following the live-weight growth curves of the ewes it was found that on a constant level of feeding the weight gains became greater during each succeeding month of pregnancy, and at corresponding stages were larger for ditocous than for monotocous ewes. This was found to be due to the fact that, although on our diet the ewes did gain slightly in actual body weight, the main increases in live weight resulted from the growth of the gravid uterus itself, and this increases in weight far more rapidly in the later stages of gestation, and is also heavier where twins are carried.

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