LOW BASELINE SERUM CREATININE (BSC) CONCENTRATION IS ASSOCIATED WITH MORTALITY IN CRITICALLY ILL PATIENTS INDEPENDENT OF BODY MASS INDEX

CHEST Journal ◽  
2007 ◽  
Vol 132 (4) ◽  
pp. 664A
Author(s):  
Rodrigo Cartin-Ceba ◽  
Bekele Afessa ◽  
Ognjen Gajic
Keyword(s):  
Body Mass Index ◽  
Serum Creatinine ◽  
Critically Ill ◽  
Body Mass ◽  
Critically Ill Patients ◽  
Baseline Serum ◽  
Baseline Serum Creatinine

scholarly journals Incidence of acute kidney injury and its association with mortality in patients with COVID-19: a meta-analysis

2020 ◽  
Vol 68 (7) ◽  
pp. 1261-1270 ◽  
Author(s):  
Panupong Hansrivijit ◽  
Chenchen Qian ◽  
Boonphiphop Boonpheng ◽  
Charat Thongprayoon ◽  
Saraschandra Vallabhajosyula ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Serum Creatinine ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Cochrane Library ◽  
Baseline Serum ◽  
Baseline Serum Creatinine ◽  
Meta Regression

Acute kidney injury (AKI) is a complication of COVID-19. However, the incidence of AKI in COVID-19 varies among studies. Thus, we aimed to evaluate the pooled incidence of AKI and its association with mortality in patients with COVID-19 using a meta-analysis. We search Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible publications reporting the clinical characteristics of patients with COVID-19 without language restriction. Incidence of AKI and mortality were reported. Meta-regression was used to describe the association between outcomes. From 26 studies (n=5497), the pooled incidence of AKI in patients with COVID-19 was 8.4% (95% CI 6.0% to 11.7%) with a pooled incidence of renal replacement therapy of 3.6% (95% CI 1.8% to 7.1%). The incidence of AKI was higher in critically ill patients (19.9%) compared with hospitalized patients (7.3%). The pooled estimated odds ratio for mortality from AKI was 13.33 (95% CI 4.05 to 43.91). No potential publication bias was detected. By using meta-regression analyses, the incidence of AKI was positively associated with mortality after adjusted for age and sex (Q=26.18; p=0.02). Moreover, age (p<0.01), diabetes (p=0.02), hypertension (p<0.01) and baseline serum creatinine levels (p=0.04) were positively associated with AKI incidence in adjusted models. In conclusion, AKI is present in 8.3% of overall patients with COVID-19 and in 19.9% of critically ill patients with COVID-19. Presence of AKI is associated with 13-fold increased risk of mortality. Age, diabetes, hypertension, and baseline serum creatinine levels are associated with increased AKI incidence.

scholarly journals Single baseline serum creatinine measurements predict mortality in critically ill patients hospitalized for acute heart failure

2015 ◽  
Vol 2 (4) ◽  
pp. 122-128 ◽  
Author(s):  
Joerg C. Schefold ◽  
Mitja Lainscak ◽  
Lea Majc Hodoscek ◽  
Stefan Blöchlinger ◽  
Wolfram Doehner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Serum Creatinine ◽  
Critically Ill ◽  
Acute Heart Failure ◽  
Critically Ill Patients ◽  
Baseline Serum ◽  
Baseline Serum Creatinine ◽  
Single Baseline

Body Mass Index Is Associated With Hospital Mortality in Critically Ill Patients

2013 ◽  
Vol 41 (8) ◽  
pp. 1878-1883 ◽  
Author(s):  
Peter Pickkers ◽  
Nicolette de Keizer ◽  
Joost Dusseljee ◽  
Daan Weerheijm ◽  
Johannes G. van der Hoeven ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Body Mass ◽  
Critically Ill Patients

scholarly journals Association between Body Mass Index and Short-Term Clinical Outcomes in Critically Ill Patients with Sepsis: A Real-World Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Shan Lin ◽  
Shanhui Ge ◽  
Wanmei He ◽  
Mian Zeng
Keyword(s):  
Body Mass Index ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Body Mass ◽  
Critically Ill Patients ◽  
Medical Information ◽  
Cox Regression ◽  
Normal Weight ◽  
Male Patients ◽  
Using Data

Background. Obesity is now recognized as one of the major public health threats, especially for patients with a critical illness. However, studies regarding whether and how body mass index (BMI) affects clinical outcomes in patients with sepsis are still scarce and controversial. The aim of our study was to determine the effect of BMI on critically ill patients with sepsis. Materials and Methods. We performed this study using data from the Medical Information Center for Intensive Care III database. A multivariate Cox regression model was used to assess the independent association of BMI with the primary outcome. Results. A total of 7,967 patients were enrolled in this study. Firstly, we found that the 28-day mortality was reduced by 22% ( HR = 0.78 , 95% CI 0.69–0.88) and 13% ( HR = 0.87 , 95% CI 0.78–0.98) for obese and overweight compared to normal weight, respectively. Subsequently, a U-shaped association of BMI with 28-day mortality was observed in sepsis patients, with the lowest 28-day mortality at the BMI range of 30–40 kg/m2. Finally, significant interactions were observed only for sex ( P = 0.0071 ). Male patients with a BMI of 25-30 kg/m2 ( HR = 0.74 , 95% CI 0.63–0.86) and 30-40 kg/m2 ( HR = 0.63 , 95% CI 0.53–0.76) had a significantly lower risk of 28-day mortality. Conclusions. A U-shaped association of BMI with 28-day mortality in critically ill sepsis patients was found, with the lowest 28-day mortality at a BMI range of 30–40 kg/m2. Notably, male patients were protected by a higher BMI more effectively than female patients as males had a significantly lower mortality risk.

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