Intra-abdominal Fat Adiponectin Receptors Expression and Cardiovascular Metabolic Risk Factors in Obesity and Diabetes

2006 ◽  
Vol 16 (6) ◽  
pp. 745-751 ◽  
Author(s):  
Rosa Morínigo ◽  
Melina Musri ◽  
Josep Vidal ◽  
Roser Casamitjana ◽  
Salvadora Delgado ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Fat ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Adiponectin Receptors ◽  
Obesity And Diabetes

scholarly journals Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243600
Author(s):  
Bahram Moazzami ◽  
Shahla Chaichian ◽  
Amir Kasaeian ◽  
Shirin Djalalinia ◽  
Meisam Akhlaghdoust ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Metabolic Risk Factors ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
Metabolic Risk ◽  
Services Delivery ◽  
Obesity And Diabetes ◽  
Pooled Prevalence

Objective Based on the epidemiologic findings of Covid-19 incidence; illness and mortality seem to be associated with metabolic risk factors. This systematic review and meta-analysis aimed to assess the association of metabolic risk factors and risk of Covid-19. Methods This study was designed according to PRISMA guidelines. Two independent researchers searched for the relevant studies using PubMed, Web of Science, Cochrane Library, and Scopus. The search terms developed focusing on two main roots of “Covid-19” and “metabolic risk factors”. All relevant observational, analytical studies, review articles, and a meta-analysis on the adult population were included in this meta-analysis. Meta-analysis was performed using the random effect model for pooling proportions to address heterogeneity among studies. Data were analyzed using STATA package version 11.2, (StataCorp, USA). Results Through a comprehensive systematic search in the targeted databases we found 1124 papers, after running the proses of refining, 13 studies were included in the present meta-analysis. The pooled prevalence of obesity in Covid-19 patients was 29% (95% CI: 14–47%). For Diabetes and Hypertension, these were 22% (95% CI: 12% 33%) and 32% (95% CI: 12% 56%), respectively. There was significant heterogeneity in the estimates of the three pooled prevalence without any significant small-study effects. Such warning points, to some extent, guide physicians and clinicians to better understand the importance of controlling co-morbid risk factors in prioritizing resource allocation and interventions. Conclusion The meta-analysis showed that hypertension is more prevalent than obesity and diabetes in patients with Covid-19 disease. The prevalence of co-morbid metabolic risk factors must be adopted for better management and priority settings of public health vaccination and other required interventions. The results may help to improve services delivery in COVID-19 patients, while helping to develop better policies for prevention and response to COVID-19 and its critical outcomes.

Computed tomography scans of intra-abdominal fat, anthropometric measurements, and 3 nonobese metabolic risk factors

Metabolism ◽  
2006 ◽  
Vol 55 (10) ◽  
pp. 1337-1343 ◽  
Author(s):  
Finn E. von Eyben ◽  
Ejvind Mouritsen ◽  
Jan Holm ◽  
Georg Dimcevski ◽  
Paulius Montvilas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Abdominal Fat ◽  
Anthropometric Measurements ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Computed Tomography Scans

scholarly journals Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Antonella Desiderio ◽  
Michele Longo ◽  
Luca Parrillo ◽  
Michele Campitelli ◽  
Giuseppe Cacace ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Factors ◽  
Dna Methylation ◽  
Epigenetic Modifications ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Human Obesity ◽  
Cpg Sites ◽  
Obesity And Diabetes ◽  
Inflammatory Profile

Abstract Background Obesity is a major worldwide threat to human health. Increasing evidence indicates that epigenetic modifications have a major impact on the natural history of this disorder. Ankyrin Repeat Domain 26 (Ankrd26) is involved in the development of both obesity and diabetes in mice and is modulated by environmentally induced epigenetic modifications. This study aims at investigating whether impaired ANKRD26 gene expression and methylation occur in human obesity and whether they correlate to the phenotype of these subjects. Results We found that downregulation of ANKRD26 mRNA and hyper-methylation of a specific region of the ANKRD26 promoter, embedding the CpG dinucleotides − 689, − 659, and − 651 bp, occur in peripheral blood leukocytes from obese compared with the lean subjects. ANKRD26 gene expression correlates inversely to the percentage of DNA methylation at these 3 CpG sites. Luciferase assays reveal a cause-effect relationship between DNA methylation at the 3 CpG sites and ANKRD26 gene expression. Finally, both ANKRD26 mRNA levels and CpG methylation correlate to body mass index and to the pro-inflammatory status and the increased cardio-metabolic risk factors of these same subjects. Conclusion Downregulation of the ANKRD26 gene and hyper-methylation at specific CpGs of its promoter are common abnormalities in obese patients. These changes correlate to the pro-inflammatory profile and the cardio-metabolic risk factors of the obese individuals, indicating that, in humans, they mark adverse health outcomes.

Abdominal fat distribution and metabolic risk factors: Effects of race

Metabolism ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1119-1124 ◽  
Author(s):  
Jennifer C. Lovejoy ◽  
Jacques A. de la Bretonne ◽  
Mark Klemperer ◽  
Richard Tulley
Keyword(s):  
Risk Factors ◽  
Fat Distribution ◽  
Abdominal Fat ◽  
Metabolic Risk Factors ◽  
Metabolic Risk
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