HAART Drugs Induce Mitochondrial Damage and Intercellular Gaps and gp120 Causes Apoptosis

2004 ◽  
Vol 4 (4) ◽  
pp. 327-338 ◽  
Author(s):  
Milan Fiala ◽  
Thomas Murphy ◽  
James MacDougall ◽  
Wendy Yang ◽  
Alfonso Luque ◽  
...  
Keyword(s):  
Mitochondrial Damage ◽  
Intercellular Gaps

A mechanism of mitochondrial damage induced by tert-butyl hydroperoxide and microsomes in vitro

1990 ◽  
Vol 80 (2) ◽  
pp. 226-232
Author(s):  
Tomoaki Matsuo ◽  
Yumiko Kashiwaki ◽  
Saburo Itoo
Keyword(s):  
Mitochondrial Damage ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Non-conjugated bile acid induces mitochondrial damage in pancreatic ductal epithelial cell

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
J Maléth ◽  
Z Rakonczay ◽  
V Venglovecz ◽  
Z Rázga ◽  
L Tiszlavicz ◽  
...  
Keyword(s):  
Bile Acid ◽  
Epithelial Cell ◽  
Mitochondrial Damage ◽  
Ductal Epithelial Cell

scholarly journals Chinese Giant Salamander (Andrias davidianus) Iridovirus Infection Leads to Apoptotic Cell Death through Mitochondrial Damage, Caspases Activation, and Expression of Apoptotic-Related Genes

2019 ◽  
Vol 20 (24) ◽  
pp. 6149 ◽  
Author(s):  
Yiqun Li ◽  
Nan Jiang ◽  
Yuding Fan ◽  
Yong Zhou ◽  
Wenzhi Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Mitochondrial Damage ◽  
Apoptotic Cell Death ◽  
Economic Losses ◽  
P53 Expression ◽  
Andrias Davidianus ◽  
Chinese Giant Salamander ◽  
Infected Cells ◽  
Apoptotic Genes

Chinese giant salamander iridovirus (GSIV) is the causative pathogen of Chinese giant salamander (Andrias davidianus) iridovirosis, leading to severe infectious disease and huge economic losses. However, the infection mechanism by GSIV is far from clear. In this study, a Chinese giant salamander muscle (GSM) cell line is used to investigate the mechanism of cell death during GSIV infection. Microscopy observation and DNA ladder analysis revealed that DNA fragmentation happens during GSIV infection. Flow cytometry analysis showed that apoptotic cells in GSIV-infected cells were significantly higher than that in control cells. Caspase 8, 9, and 3 were activated in GSIV-infected cells compared with the uninfected cells. Consistently, mitochondria membrane potential (MMP) was significantly reduced, and cytochrome c was released into cytosol during GSIV infection. p53 expression increased at an early stage of GSIV infection and then slightly decreased late in infection. Furthermore, mRNA expression levels of pro-apoptotic genes participating in the extrinsic and intrinsic pathway were significantly up-regulated during GSIV infection, while those of anti-apoptotic genes were restrained in early infection and then rose in late infection. These results collectively indicate that GSIV induces GSM apoptotic cell death involving mitochondrial damage, caspases activation, p53 expression, and pro-apoptotic molecules up-regulation.

scholarly journals Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage

2021 ◽  
Vol 14 (9) ◽  
pp. 101159
Author(s):  
Li-Ting Niu ◽  
Yu-Qing Wang ◽  
Catherine C.L. Wong ◽  
Shuai-Xin Gao ◽  
Xiao-Dong Mo ◽  
...  
Keyword(s):  
Mitochondrial Damage ◽  
Ifn Γ ◽  
Thiol Reductase

Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells

2021 ◽  
Author(s):  
Hyesu Jeon ◽  
Yujin Jin ◽  
Chang-Seon Myung ◽  
Kyung-Sun Heo
Keyword(s):  
Mitochondrial Damage ◽  
Ampk Activation ◽  
Anti Cancer ◽  
Mcf 7

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA

ACS Nano ◽  
2020 ◽  
Author(s):  
Meng Zhao ◽  
Shuyun Liu ◽  
Chengshi Wang ◽  
Yizhuo Wang ◽  
Meihua Wan ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Extracellular Vesicles ◽  
Mitochondrial Damage
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