Suppression of Body Weight Gain Preserves Acute Insulin Response to Glucose in the Portal Vein of Spontaneously Type 2 Diabetic Rats with Visceral Obesity

An inhibitor of α-amylase was isolated and purified from an extract of white kidney beans (Phaseolus vulgaris). The acute oral administration of the inhibitor (50 mg/kg body weight) to adult Wistar rats together with a starch load (2 g/kg body weight suspended in NaCl (9 g/l)) reduced the increase in glycaemia over the basal value (NaCl, 222 (SEM 49); inhibitor, 145 (SEM 16) mmol/l×180 min; P<0.05) without modifying the insulin response. On administering the inhibitor orally (50 mg/kg body weight dissolved in NaCl (9 g/l)) for 21 d to rats fed on a standard diet, a decline was observed in the glycaemia values on day 0 (NaCl, 5.53 (SEM 0.12); inhibitor, 5.25 (SEM 0.16) mmol/l) relative to those obtained on days 10 (NaCl, 5.00 (SEM 0.14); inhibitor, 4.60 (SEM 0.08) mmol/l; P<0.05) and 21 (NaCl, 5.22 (SEM 0.22); inhibitor, 4.50 (SEM 0.12) mmol/l; P<0.01) of treatment, without modifying the plasma concentration of insulin. There was found to be a significant anorexigenic action of the inhibitor; there was reduced food intake (NaCl, 23.07 (SEM 0.31); inhibitor, 19.50 (SEM 0.49) g/d; P<0.01), a reduced weight gain (NaCl, 52 (SEM 3); inhibitor, −1.33 (SEM 8.9) g/21 d; P<0.01), as well as changes in the activity of some intestinal enzymes such as maltase (NaCl, 87 (SEM 7); inhibitor, 127 (SEM 11) U/g proteins; P<0.05). The present study has shown, for the first time, that the prolonged administration of an α-amylase inhibitor reduces blood glucose levels and body-weight gain in Wistar rats.

Download Full-text

Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes

Diabetes Care ◽

10.2337/dc06-0254 ◽

2006 ◽

Vol 29 (8) ◽

pp. 1826-1832 ◽

Cited By ~ 125

Author(s):

J. Martin ◽

Z. Q. Wang ◽

X. H. Zhang ◽

D. Wachtel ◽

J. Volaufova ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Weight ◽

Weight Gain ◽

Insulin Sensitivity ◽

Body Weight Gain ◽

Chromium Picolinate

Download Full-text

I-M-150847, a novel GLP-1 and GIP receptor dual agonist, reduces body weight gain and improves glycemic control in the rodent model of type 2 diabetes and obesity.

10.1101/2021.12.05.471325 ◽

2021 ◽

Author(s):

PRASENJIT MITRA ◽

Rathin Bauri ◽

Shilpak Bele ◽

Jhansi Edelli ◽

Sourav Dasadhikari ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Weight ◽

Weight Gain ◽

Body Weight Gain ◽

Single Amino Acid ◽

The Novel ◽

Diabetes And Obesity ◽

Dual Agonist ◽

Gip Receptor

We report the discovery of a novel glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist that shows balanced agonism towards both the incretin receptor. The dual agonism of GLP-1 and GIP receptor was achieved by replacing the tryptophan cage of exendin-4 with the C- terminal undecapeptide sequence of oxyntomodulin along with a single amino acid substitution from histidine to tyrosine at the amino terminus of the peptide. The structural modification places lysine 30 of the novel incretin agonist in frame with the corresponding lysine residue in the native GIP sequence. The novel incretin agonist, named I-M-150847, promotes robust glucose-stimulated insulin exocytosis in cultured pancreatic beta cells. Chronic administration of I-M-150847 to mice fed on the high-fat diet improves glucose tolerance, decreases food intake, decreases visceral adiposity and body weight gain demonstrating its therapeutic potential in ameliorating type 2 Diabetes and Obesity.

Download Full-text

Effects of Kepok Banana Flour on Glucose Level and Physical Performance in Type 2 Diabetic Rats

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1162.137 ◽

2021 ◽

Vol 1162 ◽

pp. 137-143

Author(s):

Muizza Nur Afifa ◽

Brian Wasita ◽

Adi Magna Patriadi Nuhriawangsa

Keyword(s):

Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Feed Intake ◽

Resistant Starch ◽

Diabetic Rats ◽

Standard Diet ◽

Banana Flour ◽

Type 2 Diabetic

Diabetes mellitus prevalence has rapidly increased globally. Food contains high resistant starch (RS) may be used as a functional food to prevent and control diabetes mellitus. Resistant starch is high in raw bananas and its products such as flour. The study aimed to evaluate effects of Kepok banana flour on blood glucose and physical performance, especially body weight and feed intake in type 2 diabetic rats induced by nicotinamide (NA) and streptozotocin (STZ). Eight-week-old male Wistar rats weighed 150-200 g were randomly divided into nondiabetic and diabetic groups. Nondiabetic group (n=7 rats) was normal control (NC) and fed with standard diet AIN-93M (American Institute of Nutrition Rodent Diets 1993 for adult maintenance), while diabetic groups (n=7 rats each group) consisted of diabetic control (DC) which fed with standard diet and 3 diabetic treatment groups (T1-T3) which fed with AIN-93M containing kepok banana flour with 4%, 8% and 12% of RS respectively for 14 days. After 14 days, mean fasting blood glucose in group T1, T2 and T3 have lower blood glucose than DC significantly (p<0.05) with the highest decrease of blood glucose was on group T3. Mean of body weight in group T1, T2, T3, and NC gained significantly compared to DC group (p<0.05). Feed intake in group T1, T2, T3, and NC were less than DC significantly (p<0.05). Administration of kepok banana flour with 4%, 8% and 12% of RS is able to decrease glucose level, to restore body weight loss and to reduce feed intake in STZ-NA induced type 2 diabetic rats. Kepok banana flour can be proposed as an alternative diet in the management of type 2 diabetes.

Download Full-text