Polymorphisms of the Myf6 gene exon 1 and their relationship with growth and reproductive traits in Jinghai Yellow Chicken

2019 ◽  
Author(s):  
X.M. Yin ◽  
M.M. Yuan ◽  
L. Chen ◽  
F.X. Chen ◽  
J.Y. Wang*
Keyword(s):  
Reproductive Traits ◽  
Exon 1 ◽  
Jinghai Yellow Chicken ◽  
Gene Exon

Genome-wide association study on reproductive traits in Jinghai Yellow Chicken

2015 ◽  
Vol 163 ◽  
pp. 30-34 ◽  
Author(s):  
G.X. Zhang ◽  
Q.C. Fan ◽  
J.Y. Wang ◽  
T. Zhang ◽  
Q. Xue ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Reproductive Traits ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Jinghai Yellow Chicken

Single nucleotide polymorphism in the STAT5b gene is associated with body weight and reproductive traits of the Jinghai Yellow chicken

2011 ◽  
Vol 39 (4) ◽  
pp. 4177-4183 ◽  
Author(s):  
X. H. Zhao ◽  
J. Y. Wang ◽  
G. X. Zhang ◽  
Y. Wei ◽  
Y. P. Gu ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Body Weight ◽  
Reproductive Traits ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Jinghai Yellow Chicken

scholarly journals Polymorphisms of two neuroendocrinecorrelated genes associated with body weight and reproductive traits in Jinghai yellow chicken

2011 ◽  
Vol 10 (54) ◽  
pp. 11124-11129 ◽  
Author(s):  
Hua Zhao Xiu ◽  
Yu Wang Jin ◽  
Xi Zhang Gen ◽  
Wei Yue ◽  
Bo Yu Ya
Keyword(s):  
Body Weight ◽  
Reproductive Traits ◽  
Jinghai Yellow Chicken

Eight SNPs of the Myf5 gene and diplotypes associated with growth and reproductive traits in Jinghai yellow chicken

2014 ◽  
Vol 41 (10) ◽  
pp. 6837-6844 ◽  
Author(s):  
Ying Tang ◽  
Tao Zhang ◽  
Genxi Zhang ◽  
Jinyu Wang ◽  
Qingcan Fan ◽  
...  
Keyword(s):  
Reproductive Traits ◽  
Jinghai Yellow Chicken

The glucocorticoid receptor gene exon 1-F promoter is not methylated at the NGFI-A binding site in human hippocampus

2007 ◽  
Vol 8 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Dirk Moser ◽  
Anne Molitor ◽  
Robert Kumsta ◽  
Thomas Tatschner ◽  
Peter Riederer ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Binding Site ◽  
Receptor Gene ◽  
Human Hippocampus ◽  
Glucocorticoid Receptor Gene ◽  
Exon 1 ◽  
Gene Exon

Analysis of Immunogenetic Factors in Myelodysplastic Syndromes (MDS) Reveals Potential Pathogenic Role Cytokine Genotypes Such as TGF-β.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2446-2446
Author(s):  
Bianca Serio ◽  
Ramon Tiu ◽  
Ania Jankowska ◽  
Zach Nearman ◽  
Christine O’Keefe ◽  
...  
Keyword(s):  
Immune Response ◽  
Clinical Features ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Healthy Donors ◽  
Tnf Α ◽  
Significant Difference ◽  
Exon 1 ◽  
Gene Exon

Abstract Pathophysiologic and clinical features of MDS are related to the phenotype of the dysplastic hematopoietic clone. The immunogenetic background resulting from complex genetic predisposition traits may influence the quality of the immune response and shape the clinical features of MDS, including the severity of cytopenias and speed of malignant evolution. To test this hypothesis we selected the following immunogenetic factors: KIR and KIR-ligand (KIR-L) genotype, as well as cytokine/receptor single nucleotide polymorphisms (SNP). We genotyped a cohort of 90 patients with MDS/sAML (30 RA/RCMD, 30 RARS/ RCMD-RS, 30 RAEB/sAML); 60 healthy donors matched for ethnicity were analyzed as a control. A group of 66 patients with aplastic anemia (AA) was used as a reference. HLA type, KIR, KIR-L haplotypes, and the following SNPs were analyzed: IL-1α (−889 T/C),IL2 (−330 T/G +166 G/T), IL4 (−1098 T/G -590 T/C -33 T/C, IL-1R (−1970 C/T), IL-1RA (mspa 111100 T/C), IL-4RA (+ 190 G/A), IL-1 β (−511 C/T, +3962 T/C), IL-6 (−174 C/G, nt565 G/A), IL-10 (−1082 G/A, -819 C/T), IL-12 (−1188 C/A), TGF-β (+10 C/T, +25 G/C), INF- γ (+874 A/T), TNF- α (−308 G/A, -238 G/A), CTLA-4 (exon 1, +49 A/G), FcgIIIR (+559 G/T) as well as SNPs in the CD45 gene (exon 4 +77 C/G, +138 A/G). In the MDS cohort, no difference in the frequency of KIR genotype constellations was identified. However, a higher frequency of 2DS5 (66% vs. 26%, p=.01) and a decreased frequency of 2DL3 (62% vs. 87% p=.02) was found when patients with hypocellular MDS (N=10) were analyzed separately. No significant difference in KIR-L C1/C2 genotype frequency between the group was found. However, an increased incidence of C2/C2 was found in high grade MDS/sAML (RAEB/sAML 44% vs. 13%, p=.02). In MDS, there was a decreased frequency of stimulatory 2DS1/C2 mismatch consistent with potentially enhanced cytotoxicity (17% vs. 44%, p=.01). No significant difference in the MDS cohort compared to control and when MDS subgroup were compared to each other, was found for the SNPs in IL-4RA, IL-12, IL-1α, IFN-γ, IL-2, IL-1 α, IL-1R, and IL4. However, when we examined the frequency of TGF- β genotypes, the MDS population showed a higher rate of TT codon 10 variant (59% vs. 32% in controls, p=.002) and of GG codon 25 variant (71% vs. 35% in controls, p=.0001), consistent with a “high secretor phenotype”. Of note is that, when AA was examined and compared to controls, a higher frequency of TGF-β high secretor genotype was found (GG codon 25 variant; 61% vs 35% in controls, p=.03). We also found a higher incidence of A/A genotype for CTLA-4 in MDS (47 vs 27, p=.001). This relationship was even more pronounced in hypocellular MDS. Moreover, hypocellular MDS was characterized by a higher prevalence of IL10 -819 T/T and -592 A/A phenotypes (40% vs 12% p=.03), which are functionally associated with a lower secretion. In sum, our findings demonstrate that various immunogenetic factors may be demonstrated in MDS patients, which may likely influence the quality of immune response and shape clinical features of MDS. Certain genotypic constellations (e.g., TGF gene variants) resemble, in particular in hypocellular MDS, a constellation seen in AA.

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