The impact of aging on spreading depolarization in the intact and ischemic rat brain

2017 ◽  
Author(s):  
Ákos Menyhárt
Keyword(s):  
Rat Brain ◽  
Spreading Depolarization ◽  
The Impact

Electrochemical Monitoring of Propagative Fluctuation of Ascorbate in the Live Rat Brain during Spreading Depolarization

2019 ◽  
Vol 58 (20) ◽  
pp. 6616-6619 ◽  
Author(s):  
Tongfang Xiao ◽  
Yuexiang Wang ◽  
Huan Wei ◽  
Ping Yu ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Rat Brain ◽  
Spreading Depolarization ◽  
Electrochemical Monitoring

Effect of lipid peroxidation conditions on calcium-dependent activity of phosphodiesterase 3′,5′-cAMP in the rat brain

Biologia ◽  
2006 ◽  
Vol 61 (6) ◽  
Author(s):  
Monika Ďurfinová ◽  
Marta Brechtlová ◽  
Branislav Líška ◽  
Želmíra Barošková
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Rat Brain ◽  
Cell Damage ◽  
Intracellular Camp ◽  
Calcium Dependent ◽  
Cellular Processes ◽  
Phosphodiesterase 3 ◽  
Higher Temperature ◽  
The Impact

Abstract3′,5′-cAMP plays an important role as a second messenger molecule controlling multiple cellular processes in the brain. Its levels are decreased by phosphodiesterases (PDEs), responsible for hydrolysis of intracellular cAMP. A part of the PDE activity is dependent on the effect of calcium, mediated by its binding to calmodulin. During oxidative stress, precisely these changes in calcium concentration are responsible for cell damage. We have examined the effects of oxidative stress conditions on the activity of PDE in rat brain homogenates. We found a different influence of activated lipid peroxidation conditions (Fe2+ with ascorbate and increased temperature) on the calcium-dependent and calcium-independent PDE activity. The inhibition of Ca2+-dependent PDE was observed, while Ca2+-independent PDE was not influenced. We assume that it might be the impact of lipid peroxidation products or any mechanism activated by the higher temperature on the interaction of the Ca2+-dependent isoform of PDE with the complex calcium-calmodulin. Another explanation might be that the formation of the functioning calcium-calmodulin complex is impossible in these conditions.

The Impact of Aging, Dietary Restriction, and Glucocorticoids on ApoE Gene Expression in Rat Brain

2008 ◽  
Vol 1053 (1) ◽  
pp. 231-232
Author(s):  
S RUZDIJIC ◽  
M PEROVIC ◽  
A MLADENOVIC ◽  
D MILANOVIC ◽  
L RAKIC ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Brain ◽  
Dietary Restriction ◽  
Apoe Gene ◽  
The Impact ◽  
Apoe Gene Expression

The impact of maternal serum on development of enolase activity in fetal rat brain cell culture

1990 ◽  
Vol 186 (2) ◽  
pp. 210-217 ◽  
Author(s):  
G.E. Shambaugh ◽  
D. Clough ◽  
L. Munari ◽  
R.R. Koehler ◽  
J.A. Radosevich
Keyword(s):  
Cell Culture ◽  
Rat Brain ◽  
Brain Cell ◽  
Maternal Serum ◽  
Fetal Rat ◽  
Brain Cell Culture ◽  
The Impact ◽  
Fetal Rat Brain

scholarly journals The Impact of CXCR4 Blockade on the Survival of Rat Brain Cortical Neurons

2016 ◽  
Vol 17 (12) ◽  
pp. 2005 ◽  
Author(s):  
José Merino ◽  
Alba Garcimartín ◽  
María López-Oliva ◽  
Juana Benedí ◽  
María González
Keyword(s):  
Rat Brain ◽  
Cortical Neurons ◽  
The Impact

scholarly journals Real-Time Optical Diagnosis of the Rat Brain Exposed to a Laser-Induced Shock Wave: Observation of Spreading Depolarization, Vasoconstriction and Hypoxemia-Oligemia

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e82891 ◽  
Author(s):  
Shunichi Sato ◽  
Satoko Kawauchi ◽  
Wataru Okuda ◽  
Izumi Nishidate ◽  
Hiroshi Nawashiro ◽  
...  
Keyword(s):  
Shock Wave ◽  
Rat Brain ◽  
Real Time ◽  
Optical Diagnosis ◽  
Spreading Depolarization ◽  
Wave Observation

scholarly journals Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging

2019 ◽  
Vol 127 ◽  
pp. 125-136 ◽  
Author(s):  
Péter Hertelendy ◽  
Dániel P. Varga ◽  
Ákos Menyhárt ◽  
Ferenc Bari ◽  
Eszter Farkas
Keyword(s):  
Cerebral Cortex ◽  
Neurological Disease ◽  
Spreading Depolarization ◽  
Disease States ◽  
The Impact
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