Cetrimonium Bromide Promoted Efficient Multi-component Protocol for
Synthesis of 1-Amidoalkyl-2-naphthols in Aqueous Medium

An efficient and eco-friendly cetrimonium bromide promoted one-pot synthesis of 1-amidoalkyl-2-naphthols by the multicomponent condensation of aldehydes, β-naphthol and amides in water is reported. The wide range of substrate scope, excellent yield, short reaction rate, operational simplicity and environmentally friendly water as medium are the prominent feature of this protocol.

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Environmental-friendly one-pot cascade synthesis of 3-cyanopiperidin-2,6-diones

Environmental Chemistry Letters ◽

10.1007/s10311-019-00915-8 ◽

2019 ◽

Vol 18 (1) ◽

pp. 165-170 ◽

Cited By ~ 3

Author(s):

Daniel Paprocki ◽

Stanisław Berłożecki ◽

Ryszard Ostaszewski

Keyword(s):

Natural Products ◽

Silica Gel ◽

Knoevenagel Condensation ◽

Environmentally Friendly ◽

Aromatic Aldehydes ◽

Cyanoacetic Acid ◽

One Pot ◽

One Pot Synthesis ◽

Environmental Friendly ◽

Wide Range

Abstract 3-Cyanopiperidin-2,6-diones are key intermediates in the synthesis of several drugs and natural products. We developed one-pot synthesis of 3-cyanopiperidin-2,6-diones by Knoevenagel condensation of cyanoacetic acid and aldehydes, followed by addition of cyanoacetic acid, Achmatowicz reaction and decarboxylation. We tested a wide range of aliphatic and aromatic aldehydes. Products were obtained under simple, environmentally friendly conditions and in yields up to 99%. Substrates were stirred in toluene at reflux, and filtered through short pad of silica gel, and the product was purified by recrystallization.

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Indium Bromide-catalyzed Unprecedented Hydrogenolysis: A Novel One-Pot Synthesis of Per-O-Acetylated β-carboxymethyl O and S-glycosides

Current Organic Chemistry ◽

10.2174/1385272824999200407093625 ◽

2020 ◽

Vol 24 (8) ◽

pp. 900-908

Author(s):

Ram Naresh Yadav ◽

Amrendra K Singh ◽

Bimal Banik

Keyword(s):

Asymmetric Synthesis ◽

Chiral Auxiliary ◽

Bioactive Molecules ◽

One Pot ◽

Enantiomerically Pure ◽

Stereoselective Glycosylation ◽

One Pot Synthesis ◽

Wide Range

Numerous O (oxa)- and S (thia)-glycosyl esters and their analogous glycosyl acids have been accomplished through stereoselective glycosylation of various peracetylated bromo sugar with benzyl glycolate using InBr3 as a glycosyl promotor followed by in situ hydrogenolysis of resulting glycosyl ester. A tandem glycosylating and hydrogenolytic activity of InBr3 has been successfully investigated in a one-pot procedure. The resulting synthetically valuable and virtually unexplored class of β-CMGL (glycosyl acids) could serve as an excellent potential chiral auxiliary in the asymmetric synthesis of a wide range of enantiomerically pure medicinally prevalent β-lactams and other bioactive molecules of diverse medicinal interest.

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Aqueous one-pot synthesis of well-defined zwitterionic diblock copolymers by RAFT polymerization: an efficient and environmentally-friendly route to a useful dispersant for aqueous pigments

Green Chemistry ◽

10.1039/d0gc04271d ◽

2021 ◽

Vol 23 (3) ◽

pp. 1248-1258

Author(s):

Shannon M. North ◽

Steven P. Armes

Keyword(s):

Iron Oxide ◽

Diblock Copolymers ◽

Raft Polymerization ◽

Environmentally Friendly ◽

Iron Oxide Particles ◽

One Pot ◽

One Pot Synthesis ◽

Highly Effective ◽

Oxide Particles

An atom-efficient, wholly aqueous one-pot synthesis of zwitterionic diblock copolymers has been devised. Such copolymers can serve as highly effective aqueous dispersants for nano-sized transparent yellow iron oxide particles.

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Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽

10.1055/s-0040-1707169 ◽

2020 ◽

Vol 31 (14) ◽

pp. 1430-1434

Author(s):

Ming Bian ◽

Jin-feng Zhou ◽

Dong-min Tang

Keyword(s):

Drug Discovery ◽

Dimethyl Sulfoxide ◽

Functional Groups ◽

Methyl Ketones ◽

One Pot ◽

One Pot Synthesis ◽

Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

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ChemInform Abstract: Nanodomain Cubic Cuprous Oxide as Reusable Catalyst in One-Pot Synthesis of 3-Alkyl/Aryl-3- (pyrrole-2-yl/indole-3-yl)-2-phenyl-2,3-dihydro-isoindolinones in Aqueous Medium.

ChemInform ◽

10.1002/chin.201441127 ◽

2014 ◽

Vol 45 (41) ◽

pp. no-no

Author(s):

Swarbhanu Sarkar ◽

Nivedita Chatterjee ◽

Manas Roy ◽

Rammyani Pal ◽

Sabyasachi Sarkar ◽

...

Keyword(s):

Aqueous Medium ◽

Cuprous Oxide ◽

Reusable Catalyst ◽

One Pot ◽

Alkyl Aryl ◽

One Pot Synthesis

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ZnO Nanoparticles: A Highly Effective and Readily Recyclable Catalyst for the One-Pot Synthesis of 1,8-dioxo-decahydroacridine and 1,8-dioxooctahydro-xanthene Derivatives

Journal of the Mexican Chemical Society ◽

10.29356/jmcs.v57i1.228 ◽

2017 ◽

Vol 57 (1) ◽

Author(s):

Javad Safaei-Ghomi ◽

Mohammad Ali Ghasemzadeh ◽

Safura Zahedi

Keyword(s):

Zno Nanoparticles ◽

Environmentally Friendly ◽

Recyclable Catalyst ◽

Solvent Free ◽

One Pot ◽

One Pot Synthesis ◽

Solvent Free Conditions ◽

Xanthene Derivatives ◽

Highly Effective ◽

The One

ZnO nanoparticles as a worthwhile and recyclable catalyst have been used for the one-pot synthesis of 1,8-dioxo-decahydroacridines and 1,8-dioxooctahydro-xanthenes via multi-component reactions under solvent-free conditions. The presented method is mild, environmentally friendly, inexpensive and highly effective to give the products in good to excellent yields.

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Nitroalkanes in Aqueous Medium as an Efficient and Eco-Friendly Source for the One-Pot Synthesis of 1,4-Diketones, 1,4-Diols, δ-Nitroalkanols, and Hydroxytetrahydrofurans

The Journal of Organic Chemistry ◽

10.1021/jo0351163 ◽

2003 ◽

Vol 68 (23) ◽

pp. 9173-9176 ◽

Cited By ~ 33

Author(s):

Roberto Ballini ◽

Luciano Barboni ◽

Guido Giarlo

Keyword(s):

Aqueous Medium ◽

One Pot ◽

One Pot Synthesis ◽

The One

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Base-Promoted Three-Component One-Pot Synthesis of 3- (Thiomethyl)indoles with Paraformaldehyde under Aqueous Conditions

Synlett ◽

10.1055/s-0037-1611023 ◽

2018 ◽

Vol 29 (20) ◽

pp. 2693-2696 ◽

Cited By ~ 6

Author(s):

Fuhong Xiao ◽

Guo-Jun Deng ◽

Shanshan Yuan ◽

Huawen Huang

Keyword(s):

Carbon Source ◽

Environmentally Friendly ◽

Green Solvent ◽

One Pot ◽

One Pot Synthesis ◽

Low Toxicity ◽

Aqueous Conditions

An ethylenediamine-promoted three-component synthesis of 3-(thiomethyl)indoles from indoles, thiophenols, and paraformaldehyde has been developed. Water is used as the green solvent in a simple and environmentally friendly procedure. Stable and low-toxicity paraformaldehyde is used as a carbon source.

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