CORRELATION OF SERUM ZINC LEVELS WITH SEVERITY OF ACNE VULGARIS

BACKGROUND Acne vulgaris is a chronic inflammatory condition of the pilosebaceous unit which occurs in adolescent age groups. Physical and psychological scars can create social issues in the family, school and workplace. The disorder is multifactorial. There are plenty of recovery choices but are not satisfactory. We wanted to investigate the serum zinc levels and the therapeutic utility of oral zinc supplementation in acne vulgaris patients. METHODS This is a prospective study conducted over a period of one and a half years among one hundred acne patients who reported to the outpatient clinic of the Department of Dermatology, Venereology and Leprology with untreated patients of acne vulgaris. RESULTS Males were 65 % and females were 35 % with male : female ratio of 6.5 : 3.5. Most of the patients were students occupying 71 % of the study. Family history was observed in 46 % of patients, either in the siblings or in the parents. Premenstrual flare-up of acne lesions was noted in 71.42 % of female patients indicating a pivotal role of hormones in the pathogenesis of acne. Aggravation of lesions in summer was noted in 45 % of patients. Aggravation of acne lesions with different types of diet like non-vegetarian food, oily food and chocolates was noticed in 69 % of the study. History of usage of different types of cosmetics available in the market was noted in 76 % of the patients. In the present study, 62 % had lower than normal serum zinc levels and 38 % had normal serum zinc levels. Thus, serum zinc levels were found to be lower in both male and female acne patients in the majority (62 %) of the study patients and also normal healthy controls. The fasting serum zinc levels in the 62 patients before and after oral zinc sulphate were estimated after completion of 3 months treatment. Normal serum zinc levels were observed in all 62 patients treated. CONCLUSIONS Oral zinc sulphate is an effective, safe and economic remedy in the treatment of acne vulgaris. The extra advantage with oral zinc sulphate is that it is devoid of many adverse reactions commonly seen after prolonged use of systemic antibiotics. KEYWORDS Oral Zinc Sulphate, Acne Vulgaris

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Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis

Dermatologic Therapy ◽

10.1111/dth.14252 ◽

2020 ◽

Vol 33 (6) ◽

Author(s):

Brittany E. Yee ◽

Phillip Richards ◽

Jennifer Y. Sui ◽

Amanda Fleming Marsch

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Acne Vulgaris ◽

Serum Zinc ◽

Zinc Treatment ◽

Zinc Levels ◽

Serum Zinc Levels

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Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

BioMed Research International ◽

10.1155/2014/474108 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Majid Rostami Mogaddam ◽

Nastaran Safavi Ardabili ◽

Nasrollah Maleki ◽

Maedeh Soflaee

Keyword(s):

Acne Vulgaris ◽

Serum Zinc ◽

Atomic Absorption Spectrophotometry ◽

Zinc Level ◽

Healthy Controls ◽

Serum Zinc Level ◽

Absorption Spectrophotometry ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P=0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

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EVALUATION OF SERUM ZINC LEVEL

The Professional Medical Journal ◽

10.29309/tpmj/2018.25.02.462 ◽

2018 ◽

Vol 25 (02) ◽

pp. 307-312

Author(s):

Thiga Mohammed Mohammed Osman Alhassan ◽

Abdelmula Mohamed Abdalla ◽

Eshtiag Mohammed Mohammed Osman Alhassan ◽

Suhair Abdelrahman Ahmed

Keyword(s):

Reference Group ◽

Acne Vulgaris ◽

Serum Zinc ◽

Zinc Level ◽

Chronic Inflammatory Disease ◽

Acrodermatitis Enteropathica ◽

Serum Zinc Level ◽

Severe Acne ◽

Zinc Levels ◽

Serum Zinc Levels

Back ground: Acne vulgaris is a common chronic inflammatory disease ofthe skin. Zinc is a trace element, exists in high amounts within the skin and especially theepidermis. Its importance for human metabolism has been noted by the dramatic improvementof acrodermatitis enteropathica following zinc supplementation. Objectives: To evaluate theserum zinc level among patients with acne vulgaris, and to correlate age, grade and durationof acne vulgaris with serum zinc level. Study Design: Case- control hospital base study.Setting: Khartoum state at Khartoum Dermatology & Venerology Hospital. Period: February toSeptember 2017. Materials Methods: 100 samples were collected from patients attending toKhartoum Dermatology & Venerology hospital suffering from acne vulgaris. Acne severity wasclassified according to Global Acne Grading System (GAGS). In addition to other 100 samplescollected from healthy individuals (students and nurse) sex and age matched as control. Thelevels of serum zinc was measured in each group by atomic absorption spectroscopy. Results:The study showed significant decrease in the zinc concentrations in acne vulgaris patientswhen compared with the reference group (0.207±0.04 mg/l versus 0.788 ± 0.14 mg/l) (p=0.000). The study observed decreased serum zinc level with advancedgrade of acne; mild47 patients (47%) (0.247 ± 0.05), moderate 33 (33%) (0.1925 ± 0.04) and severe in 20 (20%)(0.180 ± 0.03), based on the anova test analysis mean serum zinc levels were significantlylower in patients with mild to moderate and to severe acne vulgaris when compared betweenacne vulgairs grades and with reference group(p ≤ 0.001, p ≤ 0.01, p ≤ 0.05 respectively).The present study showed no correlation between zinc level (mg/l) and age in patient with acnevulgaris (years) (r=0.032, P =0.827). On the other hand significant correlation was recordedbetween serum zinc level (mg/l) and duration of the acne vulgaris in the study group (r=-0.311,p = 0.028). Conclusion: Study revealed that serum zinc levels is significantly decreased inpatients with acne vulgaris, and prescribing zinc supplement treatments help increasing thesuccess rate of acne treatment.

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Role of serum zinc levels in simple febrile convulsions in children

MedPulse International Journal of Pediatrics ◽

10.26611/10149111 ◽

2019 ◽

Vol 9 (1) ◽

pp. 36-38

Author(s):

S W Srikanth ◽

◽

Sharanagouda Patil ◽

Rachapudi Venkata Anusha ◽

◽

...

Keyword(s):

Serum Zinc ◽

Febrile Convulsions ◽

Zinc Levels ◽

Serum Zinc Levels

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Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽

10.3390/nu13062077 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2077

Author(s):

Jiun-Chi Huang ◽

Ya-Chin Huang ◽

Pei-Yu Wu ◽

Wen-Hsien Lee ◽

Yi-Chun Tsai ◽

...

Keyword(s):

Diastolic Dysfunction ◽

Left Atrial Volume ◽

Serum Zinc ◽

Zinc Level ◽

Volume Index ◽

Serum Zinc Level ◽

Lower Serum ◽

Echocardiographic Parameters ◽

Zinc Levels ◽

Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

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Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients

Nutrients ◽

10.3390/nu12103187 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3187

Author(s):

Tatsunori Toida ◽

Reiko Toida ◽

Shou Ebihara ◽

Risa Takahashi ◽

Hiroyuki Komatsu ◽

...

Keyword(s):

Body Composition ◽

Regression Analysis ◽

Cardiovascular Events ◽

Serum Zinc ◽

Fluid Volume ◽

The Body ◽

All Cause Mortality ◽

Cox's Regression ◽

Zinc Levels ◽

Serum Zinc Levels

Background: The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. Methods: This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45–59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox’s regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Results: Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox’s regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Conclusion: Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.

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