scholarly journals EVALUATION OF SERUM ZINC LEVEL

2018 ◽  
Vol 25 (02) ◽  
pp. 307-312
Author(s):  
Thiga Mohammed Mohammed Osman Alhassan ◽  
Abdelmula Mohamed Abdalla ◽  
Eshtiag Mohammed Mohammed Osman Alhassan ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Reference Group ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Level ◽  
Chronic Inflammatory Disease ◽  
Acrodermatitis Enteropathica ◽  
Serum Zinc Level ◽  
Severe Acne ◽  
Zinc Levels ◽  
Serum Zinc Levels

Back ground: Acne vulgaris is a common chronic inflammatory disease ofthe skin. Zinc is a trace element, exists in high amounts within the skin and especially theepidermis. Its importance for human metabolism has been noted by the dramatic improvementof acrodermatitis enteropathica following zinc supplementation. Objectives: To evaluate theserum zinc level among patients with acne vulgaris, and to correlate age, grade and durationof acne vulgaris with serum zinc level. Study Design: Case- control hospital base study.Setting: Khartoum state at Khartoum Dermatology & Venerology Hospital. Period: February toSeptember 2017. Materials Methods: 100 samples were collected from patients attending toKhartoum Dermatology & Venerology hospital suffering from acne vulgaris. Acne severity wasclassified according to Global Acne Grading System (GAGS). In addition to other 100 samplescollected from healthy individuals (students and nurse) sex and age matched as control. Thelevels of serum zinc was measured in each group by atomic absorption spectroscopy. Results:The study showed significant decrease in the zinc concentrations in acne vulgaris patientswhen compared with the reference group (0.207±0.04 mg/l versus 0.788 ± 0.14 mg/l) (p=0.000). The study observed decreased serum zinc level with advancedgrade of acne; mild47 patients (47%) (0.247 ± 0.05), moderate 33 (33%) (0.1925 ± 0.04) and severe in 20 (20%)(0.180 ± 0.03), based on the anova test analysis mean serum zinc levels were significantlylower in patients with mild to moderate and to severe acne vulgaris when compared betweenacne vulgairs grades and with reference group(p ≤ 0.001, p ≤ 0.01, p ≤ 0.05 respectively).The present study showed no correlation between zinc level (mg/l) and age in patient with acnevulgaris (years) (r=0.032, P =0.827). On the other hand significant correlation was recordedbetween serum zinc level (mg/l) and duration of the acne vulgaris in the study group (r=-0.311,p = 0.028). Conclusion: Study revealed that serum zinc levels is significantly decreased inpatients with acne vulgaris, and prescribing zinc supplement treatments help increasing thesuccess rate of acne treatment.

scholarly journals Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Majid Rostami Mogaddam ◽  
Nastaran Safavi Ardabili ◽  
Nasrollah Maleki ◽  
Maedeh Soflaee
Keyword(s):  
Acne Vulgaris ◽  
Serum Zinc ◽  
Atomic Absorption Spectrophotometry ◽  
Zinc Level ◽  
Healthy Controls ◽  
Serum Zinc Level ◽  
Absorption Spectrophotometry ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P=0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

scholarly journals Role of zinc in acne: a study of 77 patients

2018 ◽  
Vol 4 (3) ◽  
pp. 301
Author(s):  
Jacob Thomas
Keyword(s):  
Acne Vulgaris ◽  
Treatment Options ◽  
Serum Zinc ◽  
Zinc Level ◽  
Chronic Inflammatory Disease ◽  
Acrodermatitis Enteropathica ◽  
Control Group ◽  
Serum Zinc Level ◽  
Pre Treatment ◽  
Average Serum

<p class="abstract"><strong>Background:</strong> Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit occurring in adolescent age group. Though not life threatening it can cause physical and psychological scars which can produce social problems in house, school and office. It is a multifactorial disease. Many treatment options are available, but not optimal. Zinc was found to be effective in pustular acne in a patient with acrodermatitis enteropathica. Hence a study on the level serum zinc in acne patients and the effect of zinc on acne is worthwhile. The aim was estimation of serum zinc level in acne patients and correlation of serum zinc level and improvement of acne.</p><p class="abstract"><strong>Methods:</strong> Pre-treatment serum zinc level was estimated in acne and non-acne patients. Acne patients were given oral zinc 220 mg two times a day and control group was given placebo. Post treatment serum zinc levels were estimated and the serum zinc level and improvement of acne was correlated.<strong></strong></p><p class="abstract"><strong>Results:</strong> Study subjects attained average serum zinc level of 5.829 µg/ml from 1.33 µg/ml. 59.5% patients on zinc therapy showed more than 50% improvement in acne severity. 10.6% showed &gt;75%, 48.9% showed 50-75%, 36.1% showed 25-50% and 4.25% patients showed less than 25% improvement.</p><p class="abstract"><strong>Conclusions:</strong> Statistically significant low levels of zinc were not observed in acne. Oral zinc sulphate 220 mg two times a day raised serum level to 5.82 µg/ml Exponential response in acne was noticed as serum zinc level was raised. Inflammatory lesions showed better response than comedo. Oral zinc has definite role in treatment of acne.</p>

scholarly journals Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2077
Author(s):  
Jiun-Chi Huang ◽  
Ya-Chin Huang ◽  
Pei-Yu Wu ◽  
Wen-Hsien Lee ◽  
Yi-Chun Tsai ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Left Atrial Volume ◽  
Serum Zinc ◽  
Zinc Level ◽  
Volume Index ◽  
Serum Zinc Level ◽  
Lower Serum ◽  
Echocardiographic Parameters ◽  
Zinc Levels ◽  
Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

scholarly journals A study of serum zinc levels in children with febrile convulsions in comparison with normal and febrile children

2020 ◽  
Vol 7 (3) ◽  
pp. 588
Author(s):  
Madhubalan T. ◽  
Chidambaranathan S. ◽  
Ramamoorthy R.
Keyword(s):  
Statistical Significance ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Normal Children ◽  
Febrile Convulsions ◽  
Significant Difference ◽  
Zinc Levels ◽  
The Brain ◽  
Serum Zinc Levels

Background: A seizure is a paroxysmal time-limited change in motor activity and or behavior that results from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain such as high fever, infection, syncope, head trauma, hypoxia, or toxins. To determine whether children with febrile convulsion have decreased serum zinc level when compared to normal children and children with fever without convulsions.Methods: The study included children admitted with bronchiolitis in between during the period of September 2018 to January 2019 at Department of Pediatrics, Raja Muthiah Medical College and Hospital. It is a case-control study. A sample size of 50 was selected for each group Totally 3 Groups, 1. Children with febrile convulsions,2. Children with fever without convulsions, 3. Normal Children.Results: The mean serum zinc level in children with febrile convulsions was 42.9 mcg/dl. The serum zinc level in children with fever and normal children was 70 mcg/dl and 71 mcg/dl respectively. On comparing the serum zinc level among the three groups statistical significance was obtained between children with febrile convulsions and the other two groups namely normal children and children with fever alone. Thus, decreased serum zinc level is a significant predisposing factor for febrile convulsions. By using Posthoc Multiple comparisons test we came to know that the Fever convulsion group is significantly different from fever and normal group. There is no significant difference between fever and normal group.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions, thus indicating that zinc deprivation plays a significant role in the pathogenesis of febrile convulsions.

scholarly journals Dysgeusia Due to Zinc Deficiency After Pancreaticoduodenectomy Requiring Continuous Intravenous Zinc Supplementation: a Case Report and Literature Review

2021 ◽  
Author(s):  
Hironobu Hata ◽  
Yojiro Ota ◽  
Katsuhiko Uesaka ◽  
Yutaka Yamazaki ◽  
Tsubasa Murata ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Oral Surgery ◽  
Oral Care ◽  
Serum Zinc ◽  
Zinc Level ◽  
Normal Serum ◽  
Acrodermatitis Enteropathica ◽  
Proximal Jejunum ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies regarding the development of zinc deficiency after PD and presented the case of a patient with zinc deficiency after PD, who required home intravenous zinc replacement.Case presentation: A 73-year-old woman with glossitis, taste disorder, and acrodermatitis enteropathica-like eruption on her fingers presented to the Division of Dentistry and Oral Surgery 69 days after PD. Her serum zinc level markedly decreased to 30 μg/dL. Oral zinc administration was inadequate to treat hypozincemia after PD; therefore, multi-trace elements were injected intravenously under readmission. Her serum zinc levels recovered, and the lesions gradually improved. Furthermore, a central venous port was implanted to maintain normal serum zinc levels, and she continued self-injecting zinc at home.Conclusion: Zinc deficiency after PD rarely occurs. The clinical oncologist community, including dentists responsible for the oral care of cancer patients, should be aware of dysgeusia associated with zinc deficiency after cancer surgery, as well as that induced by chemotherapy or head and neck radiation therapy.

scholarly journals Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human Brain

2021 ◽  
Author(s):  
Jee Wook Kim ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Jun Ho Lee ◽  
Min Jung Kim ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Beta Amyloid ◽  
Zinc Level ◽  
Amyloid Deposition ◽  
Serum Zinc Level ◽  
Positron Emission ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Abstract Background: Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Ab) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods: A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 µg/dL (low), 80 to 90 µg/dL (medium), and > 90 µg/dL (high). Results: A low serum zinc level was significantly associated with increased Ab retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Ab retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions: Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.

scholarly journals Estimation of serum zinc levels in children with febrile convulsions

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

scholarly journals Association between serum zinc level and simple febrile seizures in children: a hospital-based study

2018 ◽  
Vol 6 (9) ◽  
pp. 3116
Author(s):  
Najmus Saqib ◽  
Mahvish Qazi
Keyword(s):  
Hospital Admissions ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Chi Square ◽  
Febrile Convulsions ◽  
Female Ratio ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

scholarly journals Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

2015 ◽  
Vol 12 (1) ◽  
pp. 40-44
Author(s):  
Itir Yegenaga ◽  
Zeki Aydin
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Inadequate Response ◽  
Recombinant Erythropoietin ◽  
Serum Zinc Level ◽  
Human Recombinant Erythropoietin ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

scholarly journals Serum zinc levels and clinical severity of dengue infection in children

2009 ◽  
Vol 49 (6) ◽  
pp. 309 ◽  
Author(s):  
Nuke Yuliana ◽  
RM Ryadi Fadil ◽  
Alex Chairulfatah
Keyword(s):  
Dengue Infection ◽  
Serum Zinc ◽  
Hemorrhagic Fever ◽  
Zinc Level ◽  
Clinical Severity ◽  
Severe Dengue ◽  
Serum Zinc Level ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

Background Immunopathogenesis of dengue infection revealsthe aberrant immune response. Zinc deficiency alters immuneresponse and therefore may associated with clinical severity ofdengue infection.Objective To indentifY the relationship between serum zinc levels and clinical severity of dengue infection in children.Methods A comparative study was conducted at the Departmentof Child Health Hasan Sadikin Hospital Bandung, from Februaryto March 2007. We included children aged ~ 14 years fulfilled theclinical criteria for dengue fever (OF), dengue hemorrhagic fever(DHF), and dengue shock syndrome (DSS) according to WHO(1997), confirmed with serologic test. Subjects were selectedconsecutively until met the sample size for each group. Serumzinc level were measured with atomic absorption spectroscopy(MS) on admission. Data were analyzed using Kruskal-Wallis andPearson chi square test. Significance was considered if P<0.05.Results The serum zinc levels were low in 47 (78.3%) children.The serum zinc level in OF, DHF, and DSS subjects were 56-81 (X±SO= 68.2±8.3) J.Lg/dL; 50-77 (X± SO = 61.6 ± 8. 7) J.Lg/dL;and35-52 (X± SO= 42.7 ± 5.4) j.tg/dL, respectively (P<0.001).The prevalence ratio ofDF to DHF and DHF to DSS were 1.444(P=0.311) and 3.353 (P=0.077), respectively.Conclusion Low serum zinc level were significantly different ineach clinical severity of dengue infection. However, low serum zinc level was not a risk factor for the development of severe dengue infection in children.

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