Compare and Correlate the Presence of Bacterial Pathogen Concentrations and Glycaemic Status in Type 2 Diabetic and Non-Diabetic Patients with Chronic Periodontitis Following Phase 1 Therapy

Effective treatment of diabetic sensorimotor polyneuropathy remains a challenge. To assess the efficacy and safety ofα-lipoic acid (ALA) over 20 weeks, we conducted a multicenter randomized withdrawal open-label study, in which 45 patients with type 2 diabetes and symptomatic polyneuropathy were initially treated with ALA (600 mg tid) for 4 weeks (phase 1). Subsequently, responders were randomized to receive ALA (600 mg qd;n=16) or to ALA withdrawal (n=17) for 16 weeks (phase 2). During phase 1, the Total Symptom Score (TSS) decreased from 8.9 ± 1.8 points to 3.46 ± 2.0 points. During phase 2, TSS improved from 3.7 ± 1.9 points to 2.5 ± 2.5 points in the ALA treated group (p<0.05) and remained unchanged in the ALA withdrawal group. The use of analgesic rescue medication was higher in the ALA withdrawal group than ALA treated group (p<0.05). In conclusion, in type 2 diabetic patients with symptomatic polyneuropathy who responded to initial 4-week high-dose (600 mg tid) administration of ALA, subsequent treatment with ALA (600 mg qd) over 16 weeks improved neuropathic symptoms, whereas ALA withdrawal was associated with a higher use of rescue analgesic drugs. This trial is registered with ClinicalTrials.gov Identifier:NCT02439879.

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A Clinical, Laboratory and Microbiological Evaluation on Efficacy of Dental Air Force Home Dental Cleaning System on Type 2 Diabetic and Nondiabetic Adult Chronic Periodontitis Patients: A 6-Month Clinical Study

International Journal of Experimental Dental Science ◽

10.5005/jp-journals-10029-1030 ◽

2013 ◽

Vol 2 (1) ◽

pp. 1-8

Author(s):

Ameet Madan Mani

Keyword(s):

Clinical Study ◽

Air Force ◽

Chronic Periodontitis ◽

Clinical Laboratory ◽

Periodontal Diseases ◽

Phase 1 ◽

Cleaning System ◽

Microbiological Parameters ◽

Type 2 Diabetic

ABSTRACT Aim The study outlined to evaluate the clinical, laboratory and microbiological efficacy of Dental Air Force home dental cleaning system on type 2 diabetes and nondiabetic adult chronic periodontitis patients. Materials and methods A total of 100 adult chronic periodontitis subjects were recruited voluntary for this study. Clinical [plaque index (PI), gingival index (GI) and clinical attachment loss (CAL)], laboratory (C-reactive protein levels and glycated hemoglobin) and microbiological parameters were measured prior to phase 1 therapy; at 3rd and 6th month post phase 1 therapy. Comparative assessment was done among all the patients that were divided into four groups with Student paired t-test and analysis of variance (ANOVA). Results The results of this study showed that there was significant decrease in clinical, laboratory and microbiological parameters from baseline to 6 months in all the groups (i.e. p < 0.01). The subjects under groups using Dental Air Force home dental cleaning system showed highly significant reduction to all the parameters as compared to subjects under groups using toothbrush. Conclusion There was strong correlation between periodontal diseases and systemic parameters. Dental Air Force home dental cleaning system with the access to interdentally area helps in preventing the accumulation of dental plaque biofilm, thus able to maintain the clinical, laboratory and microbiological parameters at much lower levels as compared to traditional tooth brushing after phase I therapy. How to cite this article Mani S, Mani AM, Saini R. A Clinical, Laboratory and Microbiological Evaluation on Efficacy of Dental Air Force Home Dental Cleaning System on Type 2 Diabetic and Nondiabetic Adult Chronic Periodontitis Patients: A 6-Month Clinical Study. Int J Experiment Dent Sci 2013;2(1):1-8.

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