scholarly journals Steroids Alone, Versus Steroids with Antihistamines, in the Treatment of Oral Lichen Planus – A Comparative Study from Chennai, India

2021 ◽  
Vol 10 (37) ◽  
pp. 3277-3282
Author(s):  
Deepigaa Manivasagam ◽  
Arvind Muthukrishnan
Keyword(s):  
Mast Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Combined Therapy ◽  
Topical Steroids ◽  
Rapid Reduction ◽  
Severity Of Disease ◽  
Group 2 ◽  
Oral Lichen ◽  
Group 1

BACKGROUND Lichen planus (LP) is a chronic T cell mediated autoimmune disorder affecting the skin and mucosa of the oral cavity. Mainstays of treatment are corticosteroids which are mostly used topically, and severe cases require systemic management. Recalcitrant or severe cases may require steroid sparing immune-modulators. Mast cells are predominant in the active phase of LP and antihistamines reduce mast cell numbers. The purpose of this study was to evaluate the effectiveness of antihistamines in oral lichen planus. METHODS This study was conducted from June 2019 to March 2020 in oral medicine department. A total of 54 patients were included in which group – 1 (n = 27) patients were treated with both systemic antihistamine with topical steroids, group – 2 (n = 27) patients were treated with topical steroids only. The Challacombe scale was used to assess the severity of disease at baseline, 15 days and 30 days. RESULTS Results showed that patients were in the age group of 51 - 60 years (27.8 %), female predilection (63 %), erosive OLP (50 %) and reticular OLP (38.8 %) was most commonly reported. Mean difference and standard deviation at first review and second review for group 1 was 9.85 ± 2.349, 8.14 ± 2.685; group 2 was 4.74 ± 2.297, 4.37 ± 2.436 respectively with a statistically significant value (< 0.05). In between the reviews, group - 1 showed a rapid reduction in severity of disease when compared to group - 2. CONCLUSIONS A combined therapy of topical steroids and systemic antihistamines was more effective in active reduction of disease and are easily available with no adverse effects reported. KEY WORDS Antihistamines; Challacombe Scale; Mast Cells; Oral Lichen Planus

scholarly journals Evaluation of Cellular Proliferative Activity in Patients with Oral Lichen Planus and Hepatitis C through AgNOR Method

2014 ◽  
Vol 25 (6) ◽  
pp. 461-465
Author(s):  
João Paulo De Carli ◽  
Soluete Oliveira da Silva ◽  
Maria Salete Sandini Linden ◽  
Carmen Silvia Busin ◽  
Luiz Renato Paranhos ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Clinical Signs ◽  
Hcv Infection ◽  
Control Group ◽  
Proliferative Potential ◽  
Group 2 ◽  
Oral Lichen

The objective of this study was to evaluate the cellular proliferative potential of oral lichen planus (OLP) lesions from patients without hepatitis C virus (HCV) by means of AgNOR method, as well as the cellular proliferative potential of the normal oral mucosa from patients with HCV, treated or untreated by interferon and ribavirin. A cross-sectional study was developed to investigate four groups: 10 HCV+ patients without clinical signs of OLP who had never been treated for HCV infection - Group 1; 10 HCV+ patients that were under interferon and ribavirin treatment - Group 2; 15 patients with reticular OLP lesions histopathologically confirmed, without HCV - Group 3; and 15 blood donors without HCV infection and no clinical signs of OLP GROUP 4 Control Group. The cytological material of all groups was collected by the liquid-based cytology technique. Then, the sedimented material from each patient was filled with the Nucleolar Organizer Regions impregnation by silver method (AgNOR). The count of NORs was performed on 100 epithelial cell nuclei per patient using the Image Tool(tm) software. The Tukey HSD test was used to compare the median value of NORs among the groups and showed that the oral mucosa of HCV+ patients previously treated with anti-HCV drugs (GROUP 2), presented a higher average number of NORs in relation to others (p<0.05). The anti-HCV treatment may be related to increased cell proliferation of oral mucosa, indicating a possible relationship between OLP and HCV+ patients treated with interferon and ribavirin.

scholarly journals Role of mast cells in pathogenesis of oral lichen planus

2011 ◽  
Vol 15 (3) ◽  
pp. 267 ◽  
Author(s):  
Rachna Sharma ◽  
Keya Sircar ◽  
Sanjeet Singh ◽  
Varun Rastogi
Keyword(s):  
Mast Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals TANTANGAN FARMAKOLOGI PENGGUNAAN STEROID TOPIKAL PADA PASIEN ORAL LICHEN PLANUS

2019 ◽  
Vol 6 (1) ◽  
pp. 30
Author(s):  
Revi Nelonda ◽  
Nanan Nur’aeny ◽  
Irna Sufiawati
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Signs ◽  
Topical Steroid ◽  
Topical Steroids ◽  
First Line ◽  
Spicy Food ◽  
Diffuse Erythema ◽  
Chronic Autoimmune Disease ◽  
Oral Lichen

Background: Oral lichen planus (OLP) is a chronic autoimmune disease sprinkled by T cells on the oral mucosal surface. The goal of OLP treatment is to eliminate erythema, ulceration and relieve symptoms. Corticosteroids are the first line in the treatment of OLP, either systemically or topically. The problem arises when using topical steroids, namely the time of topical steroid attachment to the oral mucosa, especially in cases of OLP with clinical desquamative gingivitis. Some studies suggest that the use of individual gingival tray can overcome this problem. Objective: To provide information on topical steroid use in OLP cases with desquamative gingivitis clinical signs.Case Management: Women, age 31, complain that pain with burning on the lips and mouth is aggravated by spicy food. Intraoral examination shows irregular white plaques on the buccal, labial and dorsal mucosa of the tongue accompanied by diffuse erythema in the anterior gingiva of the upper and lower jaws. Patients diagnosed with OLP. Lesions improve 3 months after topical steroid administration, except lesions on the gingiva. Gingival individual tray is then used to obtain adequate attachment of topical steroids on the gingiva surface. The gingiva showed significant improvement after a month later.Conclusion: The use of topical steroid concoctions applied to the gingival individual tray is effective in treating OLP lesions especially with clinical signs of desquamative gingivitis.

scholarly journals Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus

2018 ◽  
Vol 6 (5) ◽  
pp. 879-884 ◽  
Author(s):  
Basma Mostafa ◽  
Mai Zakaria
Keyword(s):  
Lichen Planus ◽  
Steroid Therapy ◽  
Oral Lichen Planus ◽  
Topical Steroid ◽  
Topical Steroids ◽  
Before And After ◽  
Reported Data ◽  
Oral Lichen ◽  
Effective Adjunct ◽  
Subsequent Improvement

AIM: The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP).METHODS: Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group). Assessment of pain and sign scores was done before and after each treatment modality.RESULTS: The results revealed that the greatest significant percentage of change and subsequent improvement in pain and sign scores were recorded in the combined group.CONCLUSION: Reported data in this study using the combination of ozone and steroid therapy could provide a new promising safe and effective adjunct therapy for management of OLP.

scholarly journals Oral lichen planus with linear lichen planus: a rare association

2019 ◽  
Vol 5 (2) ◽  
pp. 429
Author(s):  
N. Padmapriya ◽  
K. Karthikeyan
Keyword(s):  
Oral Cavity ◽  
Lichen Planus ◽  
Rare Variant ◽  
Oral Lichen Planus ◽  
Skin Lesions ◽  
Topical Steroids ◽  
Rare Association ◽  
Oral Lichen

<p class="abstract">Lichen planus (LP) is a papulosquamous disorder with both cutaneous and mucosal manifestation. Linear lichen planus is rare variant of lichen planus which occurs in the extremities. Oral lichen planus is another variant of lichen planus. Coexistence of linear lichen planus with oral lichen planus is rare and only one case has been reported before this case. A 35 year old female presented with hyperpigmented linear lesion in the leg and whitish plaques in the oral cavity. Biopsy of the skin lesions showed features of lichen planus. The patient was started on topical steroids and oral hydroxychloroquine. Patient responded to treatment.</p>

scholarly journals Degranulated mast cells and TNF-α in oral lichen planus and oral lichenoid reactions diseases

2012 ◽  
Vol 1 (1) ◽  
pp. 52 ◽  
Author(s):  
Zahra Saberi ◽  
Parichehr Ghalayani ◽  
Gholamreza Jahanshahi
Keyword(s):  
Mast Cells ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tnf Α ◽  
Lichenoid Reactions ◽  
Oral Lichen
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