Development of novel nanoparticulate polymeric delivery system for peptide vaccines against group A streptococcus

2019 ◽  
Author(s):  
Reshma Jayprakash Nevagi
Keyword(s):  
Delivery System ◽  
Group A Streptococcus ◽  
Peptide Vaccines ◽  
Polymeric Delivery ◽  
Group A

scholarly journals Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus

2019 ◽  
Vol 10 (9) ◽  
pp. 1253-1259 ◽  
Author(s):  
Armira Azuar ◽  
Lili Zhao ◽  
Tsui Ting Hei ◽  
Reshma J. Nevagi ◽  
Stacey Bartlett ◽  
...  
Keyword(s):  
Cholic Acid ◽  
Delivery System ◽  
Group A Streptococcus ◽  
Vaccine Candidates ◽  
Group A

Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine

2011 ◽  
Vol 7 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Mehfuz Zaman ◽  
Mariusz Skwarczynski ◽  
Jessica M. Malcolm ◽  
Carl N. Urbani ◽  
Zhongfan Jia ◽  
...  
Keyword(s):  
Delivery System ◽  
Group A Streptococcus ◽  
Group A ◽  
Nanoparticulate Delivery

scholarly journals Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus

2016 ◽  
Vol 513 (1-2) ◽  
pp. 410-420 ◽  
Author(s):  
Nirmal Marasini ◽  
Zeinab G. Khalil ◽  
Ashwini Kumar Giddam ◽  
Khairunnisa Abdul Ghaffar ◽  
Waleed M. Hussein ◽  
...  
Keyword(s):  
Delivery System ◽  
Glycolic Acid ◽  
Group A Streptococcus ◽  
Vaccine Delivery ◽  
Vaccine Delivery System ◽  
Lipid Core ◽  
Group A ◽  
Core Peptide ◽  
Intranasal Vaccine

scholarly journals Recent Advances in the Development of Peptide Vaccines and Their Delivery Systems Against Group A Streptococcus

Vaccines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 58 ◽  
Author(s):  
Azuar ◽  
Jin ◽  
Mukaida ◽  
Hussein ◽  
Toth ◽  
...  
Keyword(s):  
Vaccine Development ◽  
Group A Streptococcus ◽  
Delivery Systems ◽  
Peptide Vaccines ◽  
Peptide Epitope ◽  
The Public ◽  
Life Threatening ◽  
Group A ◽  
Preclinical And Clinical Studies ◽  
Traditional Approaches

Group A Streptococcus (GAS) infection can cause a variety of diseases in humans, ranging from common sore throats and skin infections, to more invasive diseases and life-threatening post-infectious diseases, such as rheumatic fever and rheumatic heart disease. Although research has been ongoing since 1923, vaccines against GAS are still not available to the public. Traditional approaches taken to develop vaccines for GAS failed due to poor efficacy and safety. Fortunately, headway has been made and modern subunit vaccines that administer minimal bacterial components provide an opportunity to finally overcome previous hurdles in GAS vaccine development. This review details the major antigens and strategies used for GAS vaccine development. The combination of antigen selection, peptide epitope modification and delivery systems have resulted in the discovery of promising peptide vaccines against GAS; these are currently in preclinical and clinical studies.

scholarly journals Cell-Penetrating Peptides-Based Liposomal Delivery System Enhanced Immunogenicity of Peptide-Based Vaccine against Group A Streptococcus

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 499
Author(s):  
Jieru Yang ◽  
Farrhana Firdaus ◽  
Armira Azuar ◽  
Zeinab G. Khalil ◽  
Nirmal Marasini ◽  
...  
Keyword(s):  
Delivery System ◽  
Vaccine Development ◽  
Group A Streptococcus ◽  
Cell Penetrating Peptides ◽  
Permeability Barrier ◽  
Opsonic Activity ◽  
Efficient System ◽  
Promising Strategy ◽  
Cell Penetrating ◽  
Group A

Peptide-based vaccine development represents a highly promising strategy for preventing Group A Streptococcus (GAS) infection. However, these vaccines need to be administered with the help of a delivery system and/or immune adjuvant. Cell-penetrating peptides (CPPs) have been used as a powerful tool for delivering various therapeutic agents, including peptides, as they can overcome the permeability barrier of cell membranes. Here, we used CPPs to deliver our lead lipopeptide-based vaccine (LCP-1). CPPs were anchored through a spacer to LCP-1-bearing multilamellar and unilamellar liposomes and administered to Swiss outbred mice. Tat47–57 conjugated to two palmitic acids via a (Gly)6 spacer (to form a liposome-anchoring moiety) was the most efficient system for triggering immune responses when combined with multilamellar liposomes bearing LCP-1. The immunostimulatory potential of a variety of other CPPs was examined following intranasal administration in mice. Among them, LCP-1/liposomes/Tat47–57 and LCP-1/liposomes/KALA induced the highest antibody titers. The antibodies produced showed high opsonic activity against clinically isolated GAS strains D3840 and GC2 203. The use of the CPP-liposome delivery system is a promising strategy for liposome-based GAS vaccine development.

Highly Immunogenic Trimethyl Chitosan-based Delivery System for Intranasal Lipopeptide Vaccines against Group A Streptococcus

2017 ◽  
Vol 14 (5) ◽  
Author(s):  
Nirmal Marasini ◽  
Khairunnisa Abdul Ghaffar ◽  
Ashwini Kumar Giddam ◽  
Michael R. Batzloff ◽  
Michael F. Good ◽  
...  
Keyword(s):  
Delivery System ◽  
Group A Streptococcus ◽  
Trimethyl Chitosan ◽  
Group A
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