scholarly journals FOLATE AND SYNTHETIC FOLIC ACID INTAKE, SERUM B VITAMIN AND HOMOCYSTEINE CONCENTRATIONS, AND COGNITIVE IMPAIRMENT IN ELDERLY BRAZILIANS

2017 ◽  
pp. 1-8
Author(s):  
V. Ferri Ross Perucha ◽  
R. de Cássia de Aquino ◽  
N. Gaspareto ◽  
E.M. Guerra-Shinohara ◽  
P. Mendonça da Silva Amorim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Serum Vitamin ◽  
The Elderly ◽  
Acid Consumption ◽  
B12 Deficiency ◽  
State Examination

Background: An increased risk of cognitive decline in the elderly with B12 deficiency has been associated with excessive synthetic folic acid in food fortification and supplements. Objectives: To assess the dietary folate and folic acid intake from food fortification, as well as serum vitamin B12, folate, iron, and homocysteine concentrations among the elderly and their relationships with cognitive changes. Design: Cross-sectional, observational study. Setting and Participants: Community-dwelling elderly (N = 40), predominantly female (90%), with an average age of 69 years. Measurements: Dietary intake information was collected using four 24-hour dietary recalls, adjusted for iron and folic acid in fortified flour and supplements. Serum vitamin B12, B6, folate, iron, and homocysteine concentrations were determined. Cognitive function was assessed using the Mini-Mental State Examination, adjusted for educational level. Results: Possible serum vitamin B12 deficiency (<258 pmol/L) was present in 5% of the elderly participants, while 27.5% had possible functional deficiency (<400 pmol/L). No serum folate deficiency (<6.8 nmol/L) was observed; however, 15% had possible deficiency (<13.6 nmol/L), and 7.5% had supraphysiological levels. Hyperhomocysteinemia (≥15 µmol/L) was present in 65% of the sample. Almost half of the participants (47.5%) showed cognitive impairment. There were no significant relationships between the Mini-Mental State Examination results and the B12, folate, iron, and homocysteine concentrations. However, the participants with serum vitamin B12 levels <400 pmol/L tended to have poorer Mini-Mental State Examination scores, which were related to older age (P = 0.045) and changes in the oral cavity (P = 0.034). In addition, folic acid consumption was inversely related with serum vitamin B12 levels (P = 0.030). Macrocytosis was not observed. Conclusions: Although Mini-Mental State Examination-assessed cognitive impairment was not related with the investigated biochemical variables, increased folic acid consumption seems to have a negative impact on vitamin B12 metabolism; therefore, fortification may be contributing to functional disability and masking hematological signs in the elderly.

scholarly journals HUBUNGAN ASUPAN ZAT GIZI MIKRO DAN AKTIVITAS FISIK DENGAN FUNGSI KOGNITIF LANSIA DI PUSKESMAS KEBON JERUK JAKARTA BARAT

2020 ◽  
Vol 11 (2) ◽  
pp. 117-126
Author(s):  
Harna Harna ◽  
Jesi Arianti ◽  
Rachmanida Nuzrina
Keyword(s):  
Vitamin B12 ◽  
Mental State ◽  
Vitamin B6 ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Physical Activities ◽  
Food Record ◽  
Cross Sectional ◽  
State Examination

Latar Belakang. Seiring bertambahnya usia, tubuh akan mengalami proses penuaan, termasuk otak. Otak akan mengalami perubahan fungsi, termasuk fungsi kognitif berupa sulit mengingat kembali, berkurangnya kemampuan dalam mengambil keputusan dan lebih lamban bertindak. Fungsi memori merupakan salah satu komponen intelektual yang paling utama, karena sangat berkaitan dengan kualitas hidup. Banyak lansia mengeluh kemunduran daya ingat yang disebut sebagai mudah lupa. Tujuan. Untuk mengetahui hubungan asupan zat gizi mikro dan aktivitas fisik dengan fungsi kognitif lansia. Metode. Penelitian ini menggunakan desain cross-sectional dengan sampel sebanyak 45 responden anggota Kelompok Lansia Bahagia di Puskesmas Kebon Jeruk, Jakarta Barat. Penelitian ini dilakukan pada bulan Desember 2018. Data fungsi kognitif diperoleh dengan menggunakan kuesioner Mini Mental State Examination (MMSE), data asupan menggunakan food record dan data aktivitas fisik diperoleh menggunakan metode Physical Activities Scale for the Elderly (PASE). Hasil. Responden berusia 61-65 tahun dengan jenis kelamin perempuan sebanyak 55,6 persen. Rata-rata asupan vitamin B6 yaitu 1,547±0,315 mg, asupan asam folat yaitu 200,99±10,26 mcg, asupan vitamin B12 yaitu 1,796±0,193 mcg, rata-rata aktivitas fisik yaitu 17,64±3,588 poin, riwayat penyakit yaitu 0,73±0,447 poin dan fungsi kognitif 25,01±3,103 poin. Terdapat hubungan signifikan antara asupan asam folat, asupan vitamin B12, dengan fungsi kognitif (p<0,05). Tidak terdapat hubungan antara asupan vitamin B6, aktivitas fisik, dan riwayat penyakit dengan fungsi kognitif (p>0,05). Kesimpulan. Penelitian ini menyimpulkan bahwa terdapat hubungan asupan asam folat dan vitamin B12 dengan fungsi kognitif pada lansia. Tetapi tidak terdapat hubungan antara asupan vitamin B6, aktivitas fisik, dan riwayat penyakit dengan fungsi kognitif.

scholarly journals To evaluate the utility of 10 warning signs questionnaire in assessment of cognitive function among elderly people

2016 ◽  
Vol 7 (01) ◽  
pp. 168-170
Author(s):  
Sunil Kumar Raina ◽  
Vishav Chander
Keyword(s):  
Cognitive Impairment ◽  
Elderly People ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Warning Signs ◽  
Correlation Data ◽  
Urban Rural ◽  
State Examination

ABSTRACT Introduction: Routine screening of high-risk elderly people for early cognitive impairment using mini-mental state examination (MMSE) and its modifications may be constrained by demographic and other variables. Warning signs (as reported by family/caregivers) may be a useful alternative. The present data analysis was carried out with the aim to identify the role of 10 warning signs screen as an alternative tool for screening for cognitive impairment among elderly. Materials and Methods: For the purpose of this analysis (correlation), data available with us from a study conducted on the elderly population (60 years and above) from selected geographical areas (Migrant, Urban, Rural, and Tribal) of Himachal Pradesh was used. Results: A high statistically significant was found between scores on 10 warning signs screen and Hindi mental state examination/Bharmouri mental state examination (modifications of MMSE). Conclusions: Ten warning signs screen can be an important screening total for assessment of cognitive impairment in the elderly Indians.

scholarly journals Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil

2008 ◽  
Vol 30 (4) ◽  
pp. 346-349 ◽  
Author(s):  
Izabella Dutra de Abreu ◽  
Paula Villela Nunes ◽  
Breno Satler Diniz ◽  
Orestes Vicente Forlenza
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Cognitive Decline ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Elderly Subjects ◽  
Cognitive State ◽  
State Examination

OBJECTIVE: To determine the diagnostic accuracy of the Mini-Mental State Examination combined to the Informant Questionnaire on Cognitive Decline in the Elderly for the identification of mild cognitive impairment. METHOD: 191 elderly subjects were assessed with the Mini-Mental State Examination, and their informants were assessed with the Informant Questionnaire on Cognitive Decline in the Elderly. Subjects were divided into three groups according to their cognitive state (controls: n = 67, mild cognitive impairment: n = 65 and dementia: n = 59), which was ascertained by clinical and neuropsychological evaluation. The diagnostic accuracy of each test in the discrimination of diagnostic groups (mild cognitive impairment vs. controls, mild cognitive impairment vs. dementia and dementia vs. controls) was examined with the aid of ROC curves. We additionally verified if the combination of both tests would increase diagnostic accuracy for mild cognitive impairment and control identification. RESULTS: The combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly scores did not increase the Mini-Mental State Examination diagnostic accuracy in the identification of patients with mild cognitive impairment. CONCLUSIONS: The present data do not warrant the combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly as a sufficient diagnostic tool in the diagnostic screening for mild cognitive impairment.

scholarly journals Cognitive impairment, the Mini-Mental State Examination and socio-demographic and dental variables in the elderly in Brazil

Gerodontology ◽  
2011 ◽  
Vol 29 (2) ◽  
pp. e34-e40 ◽  
Author(s):  
Leonardo de Paula Miranda ◽  
Marise F. Silveira ◽  
Thatiane L. Oliveira ◽  
Sâmia F. F. Alves ◽  
Hercílio M. Júnior ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
State Examination

scholarly journals DETERIORO COGNITIVO Y SU INFLUENCIA EN LAS ACTIVIDADES BÁSICAS DE LA VIDA DIARIA DEL ADULTO MAYOR.

2018 ◽  
Vol 2 (3) ◽  
pp. 53-62
Author(s):  
Julio Rivera-Ruiz ◽  
Carmen Graciela Zambrano Villalba
Keyword(s):  
Cognitive Impairment ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Daily Life ◽  
The Elderly ◽  
Cognitive Deterioration ◽  
Activities Of Daily Life ◽  
Katz Index ◽  
Health Organization ◽  
State Examination

En el desarrollo de esta investigación se estudió el deterioro cognitivo de los adultos mayores, siendo la principal afectación en el avance evolutivo que muchos de los mismos padecen. El objetivo del estudio fue determinar de qué manera influye el deterioro cognitivo en las actividades básicas de la vida diaria de los adultos mayores, buscando analizar la correlación que propicia dicha problemática en las acciones comportamentales de tales sujetos. La muestra de estudio estuvo conformada por 100 participantes que fluctuaron entre los 65 a 80 años de edad, los mismos que accedieron a participar en el desarrollo de este proyecto. Para la recolección de datos se utilizó el test de Escala Mini Mental State Examination MMSE de Creavin, Wisniewski y Thom, el cual sirvió para detectar el deterioro cognitivo mediante el ejercicio de pregunta-respuesta; el segundo instrumento fue el test de Evaluación de Actividades Básicas de la Vida Diaria con el Índice de Katz Modificado por la Organización Panamericana de Salud el cual se trata de una escala de preguntas, cuyos grados reflejan niveles de conducta en seis funciones. Los datos fueron analizados de forma descriptiva y analítica. Entre las conclusiones con mayor preeminencia, se halla que, a mayor deterioro cognitivo mayor afectación en la funcionalidad de los sujetos de estudio.   Abstract In the development of this research, the cognitive deterioration of the elderly was studied, being the main affectation in the evolutionary advance that many of them suffer. The objective of the study was to determine how cognitive impairment influences the basic activities of daily life of older adults, seeking to analyze the correlation that causes this problem in the behavioral actions of such subjects. The study sample consists of 100 participants ranging from 65 to 80 years of age, who agreed to participate in the development of this project. For the data collection, the Mini Mental State Examination Scale MMSE test of Craven, Wisniewski and Thom was used, which served to detect the cognitive deterioration by means of the question-answer exercise; The second instrument was the Evaluation of Basic Activities of Daily Life test with the Katz Index Modified by the Pan American Health Organization, which is a scale of questions, whose grades reflect levels of behavior in six functions. The data was analyzed in a descriptive and analytical manner. Among the conclusions with greater pre-eminence, it is found that, the greater the cognitive impairment, the greater the effect on the functionality of the study subjects

scholarly journals Prevalence and incidence of cognitive impairment in an elder Portuguese population (65–85 years old)

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ricardo Pais ◽  
Luís Ruano ◽  
Carla Moreira ◽  
Ofélia P. Carvalho ◽  
Henrique Barros
Keyword(s):  
Cognitive Impairment ◽  
Life Expectancy ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
European Population ◽  
Average Life ◽  
Average Life Expectancy ◽  
Portuguese Population ◽  
State Examination

Abstract Background The increase in average life expectancy increases the risk of illness and frailty in the elderly, especially in the cognitive arena. This study has the objective to estimate the prevalence and incidence of cognitive impairment, in a representative sample of 65 to 85 years old followed for a mean period of 6-years. Methods Subjects aged 65–85 years (n = 586) were screened at baseline (1999–2004) to estimate the prevalence of cognitive impairment using the Mini-Mental State Examination. A total of 287 individuals with a normal MMSE at baseline were reassessed after 6.2 mean years (± 4.30 years) to evaluate the incidence of cognitive impairment, defined as scoring below the age and education-adjusted MMSE cut-off points adapted for the Portuguese population. We did not exclude Dementia. Results The baseline prevalence of cognitive impairment was 15.5% (95% CI: 12.7–18.7). Higher in women (18.9%; 95% CI: 14.9–23.3), that in men (10.4%; 95% CI: 6.7–15.1). Increased with age and was highest for participants without any schooling. The overall incidence rate was 26.97 per 1000 person-years; higher in women (33.8 per 1000 person-years) than in men (18.0 per 1000 person-years). Higher for the oldest participants and those with no schooling. Taking the standard European population, we estimated a prevalence of 16.5% and an incidence of 34.4 per 1000 person-years. Conclusion The prevalence of cognitive impairment in Portugal is within the estimated interval for the European population, and the incidence is lower than for the majority of the European countries. Women, senior and elders without education have a higher risk of cognitive impairment. In our sample, neither employment nor marital status has a significant effect on cognitive impairment.

Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)

2021 ◽  
Vol 2021 (7) ◽  
Author(s):  
Ingrid Arevalo-Rodriguez ◽  
Nadja Smailagic ◽  
Marta Roqué-Figuls ◽  
Agustín Ciapponi ◽  
Erick Sanchez-Perez ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Mental State ◽  
Mini Mental State Examination ◽  
State Examination

scholarly journals Preoperative Cognitive Impairment as a Predictor of Postoperative Outcomes in Elderly Patients Undergoing Spinal Surgery for Degenerative Spinal Disease

2021 ◽  
Vol 10 (7) ◽  
pp. 1385
Author(s):  
Hyung Cheol Kim ◽  
Seong Bae An ◽  
Hyeongseok Jeon ◽  
Tae Woo Kim ◽  
Jae Keun Oh ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Elderly Patients ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Operation Time ◽  
Cognitive Status ◽  
Blood Analysis ◽  
Spinal Disease ◽  
Degenerative Spinal Disease ◽  
State Examination

Cognitive status has been reported to affect the peri-operative and post-operative outcomes of certain surgical procedures. This prospective study investigated the effect of preoperative cognitive impairment on the postoperative course of elderly patients (n = 122, >65 years), following spine surgery for degenerative spinal disease. Data on demographic characteristics, medical history, and blood analysis results were collected. Preoperative cognition was assessed using the mini-mental state examination, and patients were divided into three groups: normal cognition, mild cognitive impairment, and moderate-to-severe cognitive impairment. Discharge destinations (p = 0.014) and postoperative cardiopulmonary complications (p = 0.037) significantly differed based on the cognitive status. Operation time (p = 0.049), white blood cell count (p = 0.022), platelet count (p = 0.013), the mini-mental state examination score (p = 0.033), and the Beck Depression Inventory score (p = 0.041) were significantly associated with the length of hospital stay. Our investigation demonstrated that improved understanding of preoperative cognitive status may be helpful in surgical decision-making and postoperative care of elderly patients with degenerative spinal disease.

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