scholarly journals Greedy measurement selection for state estimation

Author(s):  
J. Nichols ◽  
Albert Cohen ◽  
Peter Binev ◽  
Olga Mula

Parametric PDEs of the general form $$ \mathcal{P}(u,a)=0 $$ are commonly used to describe many physical processes, where $\mathcal{P}$ is a differential operator, a is a high-dimensional vector of parameters and u is the unknown solution belonging to some Hilbert space V. Typically one observes m linear measurements of u(a) of the form $\ell_i(u)=\langle w_i,u \rangle$, $i=1,\dots,m$, where $\ell_i\in V'$ and $w_i$ are the Riesz representers, and we write $W_m = \text{span}\{w_1,\ldots,w_m\}$. The goal is to recover an approximation $u^*$ of u from the measurements. The solutions u(a) lie in a manifold within V which we can approximate by a linear space $V_n$, where n is of moderate dimension. The structure of the PDE ensure that for any a the solution is never too far away from $V_n$, that is, $\text{dist}(u(a),V_n)\le \varepsilon$. In this setting, the observed measurements and $V_n$ can be combined to produce an approximation $u^*$ of u up to accuracy $$ \Vert u -u^*\Vert \leq \beta^{-1}(V_n,W_m) \, \varepsilon $$ where $$ \beta(V_n,W_m) := \inf_{v\in V_n} \frac{\Vert P_{W_m}v\Vert}{\Vert v \Vert} $$ plays the role of a stability constant. For a given $V_n$, one relevant objective is to guarantee that $\beta(V_n,W_m)\geq \gamma >0$ with a number of measurements $m\geq n$ as small as possible. We present results in this direction when the measurement functionals $\ell_i$ belong to a complete dictionary.

Mathematics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 779
Author(s):  
Ruriko Yoshida

A tropical ball is a ball defined by the tropical metric over the tropical projective torus. In this paper we show several properties of tropical balls over the tropical projective torus and also over the space of phylogenetic trees with a given set of leaf labels. Then we discuss its application to the K nearest neighbors (KNN) algorithm, a supervised learning method used to classify a high-dimensional vector into given categories by looking at a ball centered at the vector, which contains K vectors in the space.


Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1045
Author(s):  
Marta B. Lopes ◽  
Eduarda P. Martins ◽  
Susana Vinga ◽  
Bruno M. Costa

Network science has long been recognized as a well-established discipline across many biological domains. In the particular case of cancer genomics, network discovery is challenged by the multitude of available high-dimensional heterogeneous views of data. Glioblastoma (GBM) is an example of such a complex and heterogeneous disease that can be tackled by network science. Identifying the architecture of molecular GBM networks is essential to understanding the information flow and better informing drug development and pre-clinical studies. Here, we review network-based strategies that have been used in the study of GBM, along with the available software implementations for reproducibility and further testing on newly coming datasets. Promising results have been obtained from both bulk and single-cell GBM data, placing network discovery at the forefront of developing a molecularly-informed-based personalized medicine.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yunqi Bu ◽  
Johannes Lederer

Abstract Graphical models such as brain connectomes derived from functional magnetic resonance imaging (fMRI) data are considered a prime gateway to understanding network-type processes. We show, however, that standard methods for graphical modeling can fail to provide accurate graph recovery even with optimal tuning and large sample sizes. We attempt to solve this problem by leveraging information that is often readily available in practice but neglected, such as the spatial positions of the measurements. This information is incorporated into the tuning parameter of neighborhood selection, for example, in the form of pairwise distances. Our approach is computationally convenient and efficient, carries a clear Bayesian interpretation, and improves standard methods in terms of statistical stability. Applied to data about Alzheimer’s disease, our approach allows us to highlight the central role of lobes in the connectivity structure of the brain and to identify an increased connectivity within the cerebellum for Alzheimer’s patients compared to other subjects.


2019 ◽  
Vol 32 (14) ◽  
pp. 4215-4234 ◽  
Author(s):  
Qin Su ◽  
Buwen Dong

Abstract Observational analysis indicates significant decadal changes in daytime, nighttime, and compound (both daytime and nighttime) heat waves (HWs) over China across the mid-1990s, featuring a rapid increase in frequency, intensity, and spatial extent. The variations of these observed decadal changes are assessed by the comparison between the present day (PD) of 1994–2011 and the early period (EP) of 1964–81. The compound HWs change most remarkably in all three aspects, with frequency averaged over China in the PD tripling that in the EP and intensity and spatial extent nearly doubling. The daytime and nighttime HWs also change significantly in all three aspects. A set of numerical experiments is used to investigate the drivers and physical processes responsible for the decadal changes of the HWs. Results indicate the predominant role of the anthropogenic forcing, including changes in greenhouse gas (GHG) concentrations and anthropogenic aerosol (AA) emissions in the HW decadal changes. The GHG changes have dominant impacts on the three types of HWs, while the AA changes make significant influences on daytime HWs. The GHG changes increase the frequency, intensity, and spatial extent of the three types of HWs over China both directly via the strengthened greenhouse effect and indirectly via land–atmosphere and circulation feedbacks in which GHG-change-induced warming in sea surface temperature plays an important role. The AA changes decrease the frequency and intensity of daytime HWs over Southeastern China through mainly aerosol–radiation interaction, but increase the frequency and intensity of daytime HWs over Northeastern China through AA-change-induced surface–atmosphere feedbacks and dynamical changes related to weakened East Asian summer monsoon.


2013 ◽  
Vol 26 (21) ◽  
pp. 8513-8528 ◽  
Author(s):  
Megan S. Mallard ◽  
Gary M. Lackmann ◽  
Anantha Aiyyer

Abstract A method of downscaling that isolates the effect of temperature and moisture changes on tropical cyclone (TC) activity was presented in Part I of this study. By applying thermodynamic modifications to analyzed initial and boundary conditions from past TC seasons, initial disturbances and the strength of synoptic-scale vertical wind shear are preserved in future simulations. This experimental design allows comparison of TC genesis events in the same synoptic setting, but in current and future thermodynamic environments. Simulations of both an active (September 2005) and inactive (September 2009) portion of past hurricane seasons are presented. An ensemble of high-resolution simulations projects reductions in ensemble-average TC counts between 18% and 24%, consistent with previous studies. Robust decreases in TC and hurricane counts are simulated with 18- and 6-km grid lengths, for both active and inactive periods. Physical processes responsible for reduced activity are examined through comparison of monthly and spatially averaged genesis-relevant parameters, as well as case studies of development of corresponding initial disturbances in current and future thermodynamic conditions. These case studies show that reductions in TC counts are due to the presence of incipient disturbances in marginal moisture environments, where increases in the moist entropy saturation deficits in future conditions preclude genesis for some disturbances. Increased convective inhibition and reduced vertical velocity are also found in the future environment. It is concluded that a robust decrease in TC frequency can result from thermodynamic changes alone, without modification of vertical wind shear or the number of incipient disturbances.


2015 ◽  
Vol 22 (6) ◽  
pp. T177-T186 ◽  
Author(s):  
Bruno M Simões ◽  
Denis G Alferez ◽  
Sacha J Howell ◽  
Robert B Clarke

Breast cancer stem cells (BCSCs) are potent tumor-initiating cells in breast cancer, the most common cancer among women. BCSCs have been suggested to play a key role in tumor initiation which can lead to disease progression and formation of metastases. Moreover, BCSCs are thought to be the unit of selection for therapy-resistant clones since they survive conventional treatments, such as chemotherapy, irradiation, and hormonal therapy. The importance of the role of hormones for both normal mammary gland and breast cancer development is well established, but it was not until recently that the effects of hormones on BCSCs have been investigated. This review will discuss recent studies highlighting how ovarian steroid hormones estrogen and progesterone, as well as therapies against them, can regulate BCSC activity.


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