scholarly journals Nefrotoxicidade e Neurotoxicidade Associadas ao Consumo da Averrhoa bilimbi e Averrhoa carambola: Uma Revisão Integrativa / Nephrotoxicity and Neurotoxicity associated with the Consumption of Averrhoa bilimbi and Averrhoa carambola: An Integrative Review

2021 ◽  
Vol 15 (58) ◽  
pp. 154-166
Author(s):  
Igor Vieira Barbosa ◽  
Israel Dos Santos Teixeira ◽  
Thais Dias de Carvalho ◽  
Matheus Santos Marques

Resumo: As espécies Averrhoa bilimbi (birí-birí) e Averrhoa carambola (carambola) pertencem à família das Oxalidaceae, o fruto que é cultivado em vários países da América do Sul. Estas frutas são habitualmente consumidas pela população, seja na forma de sucos, geléias, doces e conservas. O grande problema é que seus consumos exagerados podem causar efeitos tóxicos que são desconhecidos pela população em geral, necessitando assim de maiores conhecimentos sobre a toxicidade destas plantas. Assim a presente pesquisa trata-se de uma revisão integrativa de literatura onde; após analisar os descritores em sites de busca na internet e aplicar os critérios de inclusão e exclusão pré-estabelecidos, foram selecionados um total de 14 artigos. Todos os artigos selecionados contemplavam de informações sobre a nefrotoxicidade dos frutos desencadeadas pela presença de sais de oxalato; bem como descreveram a neurotoxicidade na carambola desencadeada pela presença da caramboxina. Assim, observa-se a necessidade do conhecimento sobre os respectivos efeitos tóxicos dessas frutas e do conhecimento etnobotânico atribuído ao profissional farmacêutico que propaga informações sobre o uso racional da fitoterapia.Palavras-chave: Averrhoa bilimbi. Averrhoa carambola. Nefrotoxicidade. Neurotoxicidade. Abstract: The species Averrhoa bilimbi (biri biri) and Averrhoa carambola (star fruit) belong to the Oxalidaceae Family, the fruit is cultivated in several South American countries. These fruits are usually consumed by the population, whether in the form of juices, jellies, candy or preserve. The big problem is that the excessive consumption can cause toxic effects that are unknown by the general population, being necessary better knowledge about the toxicity of these plants. Thus, this research is about the integrative literature revision where; after analyzing the descriptors on websites and apply the pre-established inclusion and exclusion criteria, a total of 14 articles were selected. All selected articles contemplated the information about the nephrotoxicity of the fruits trigged by the presence of oxalate salt; as well as described the neurotoxicity of the star fruit trigged by the presence of caramboxin. In that way, there is a need for knowledge about these respective toxic effects of these fruits and for ethnobotanical knowledge assigned to the pharmacist that spreads information about the rational use of herbal medicine. Keywords: Averrhoa bilimbi. Averrhoa carambola. Nephrotoxicity. Neurotoxicity.  

2021 ◽  
pp. 33-34
Author(s):  
B. Sravanthi ◽  
N. Lakshmi Bhavani

The paper deals with a phytochemical investigation on the fruit of Averrhoa carambola L. belonging to the family Oxalidaceae. Commonly known as “star fruit”. Fruits and leaves are used widely in Ayurveda preparations to pacify impaired Kapha, pitta, skin diseases, pruritis, worm infestations, diarrhea, vomiting, hemorrhoids, intermittent fever, over-perspiration, and general debility. In the present study fruits of Averrhoa carambola L. were screened for their phytochemical constituents following hot continuous and successive extraction by Soxhlet apparatus. A qualitative assay was done using a range of solvents. The extraction process was carried using different solvents successively in the order of increasing polarity. Qualitative analysis of the extracts using standard procedures revealed the presence of alkaloids, avonoids, tannins, saponins, glycosides, steroids&terpenoids, phenols, coumarins, and phytosterols. Preliminary screening of phytochemicals is a valuable step, in the detection of the bioactive principles present in medicinal plants and subsequently, may lead to drug discovery and development.


2018 ◽  
Vol 153 ◽  
pp. 156-162 ◽  
Author(s):  
Xuchao Jia ◽  
Haihui Xie ◽  
Yueming Jiang ◽  
Xiaoyi Wei

Author(s):  
SITI MARDHIYAH ◽  
BERNA ELYA ◽  
ARIKADIA NOVIANI

Objective: Premature skin aging is caused by increased elastase proteolytic activity, which causes elastin breakdown and disorganization in connectivetissue, reducing elasticity and flexibility, and wrinkling skin. Natural compounds in plants, especially polyphenols, inhibit elastase proteolyticactivity and prevent premature skin aging. Star fruit (Averrhoa carambola L.) leaves contain many polyphenols with antioxidant, anti-inflammatory,hypoglycemic, and antimicrobial activities. However, no studies have shown that A. carambola leaves inhibit elastase proteolytic activity.Methods: This study tested the inhibition of elastase proteolytic activity by the water fractions (WF), ethyl acetate fractions, and n-hexane fractionsof A. carambola leaves from the Depok, Sukabumi, and Subang regions of West Java. Each fraction was tested using a microplate reader, and the totalphenolic and flavonoid content was determined for the most active fraction.Results: The WF of the A. carambola leaves from Depok was the most active fraction, with a half-maximal inhibitory concentration of 160.36 μg/mL.The total phenolic and flavonoid content in the WF was 115.68 mg gallic acid equivalent/g extract and 9.15 mg quercetin equivalent/g extract,respectively.Conclusion: The WF of A. carambola leaves is a natural material that may inhibit elastase proteolytic activity and prevents premature skin aging.


2014 ◽  
Vol 7 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Rupal A. Vasant ◽  
A. V. R. L. Narasimhacharya

ABSTRACT Consumption of fluoride leads to several physiological disturbances in carbohydrate, lipid and antioxidant metabolisms. Averrhoa carambola L. fruit (Star fruit) is a commonly consumed fruit in tropical countries and is an ingredient in folklore medicines. As the fruits have high polyphenolic and antioxidant contents, the present study was undertaken to investigate the potential of star fruit as a dietary supplement in attenuating the fluoride induced hyperglycemia, hypercholesterolemia and oxidative stress in laboratory rats. A four-week exposure to fluoride caused sustained hyperglycemia, hyperlipidemia and oxidative stress and, when the diet was supplemented with star fruit powder, carbohydrate, lipid and antioxidant profiles were restored significantly. It is surmised that the antihyperglycemic, antihypercholesterolemic and antioxidant activities of star fruit in fluoride exposed rats could be due to the presence of polyphenols, flavonoids, saponins, phytosterols, ascorbic acid and fibers in the fruit, which are all well known regulators of carbohydrate, lipid and antioxidant metabolisms. These findings suggest that star fruit can be used as a dietary supplement in fluoride endemic regions to contain fluoride induced hyperglycemia, hyperlipidemia and oxidative stress


Renal Failure ◽  
2002 ◽  
Vol 24 (3) ◽  
pp. 379-382 ◽  
Author(s):  
Chin-Tung Chang ◽  
Yung-Chang Chen ◽  
Ji-Tseng Fang ◽  
Chiu-Ching Huang

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