Occult HCV Elicits Oxidative Stress and Triggers PI3 Kinase Mediated DNA Damage Response in Peripheral Blood Lymphocytes

2012 ◽  
Vol 107 ◽  
pp. S144
Author(s):  
Subodh Varshney ◽  
Pradyumna Mishra ◽  
Ajit Sewkani ◽  
Sachin Gupta ◽  
A. Bhargava ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Pi3 Kinase ◽  
Blood Lymphocytes ◽  
Damage Response

scholarly journals Ameliorative Effect of Eugenol and Anethole on Arsenic Induced Oxidative DNA Damage in Cultured Human Peripheral Blood Lymphocytes

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
Anita Yadav ◽  
Surbhi Bal ◽  
Neha Verma ◽  
Neeraj K. Aggarwal ◽  
Ranjan Gupta
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Dna Damage ◽  
Peripheral Blood ◽  
Oxidative Dna Damage ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Tail Moment ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes

Arsenic contamination is one of the major health concerns all over the world and associated with various types of cancer and pathological effects. The production of reactive oxygen species (ROS) plays a crucial role in arsenic mediated toxicity. Several studies have shown that population constantly exposed to arsenic have substantial oxidative stress that, in turn, induces DNA damage. In the present work eugenol and anethole were investigated for their protective effect against arsenic mediated oxidative DNA damage in peripheral blood lymphocytes. Comet assay and lipid peroxidation was used as biomarker of genotoxicity and oxidative stress respectively. A dose dependent increase in tail moment and lipid peroxidation was observed when lymphocytes were treated with sodium arsenite. Treatment of arsenic (50?M) along with eugenol (20?M) and anethole (50?M) showed a significant decrease in the tail moment and lipid peroxidation in cultured peripheral blood lymphocytes. The decrease in the tail moment and lipid peroxidation was significantly higher in combined supplementation of eugenol and anethole as compared to individual administration. The results of the present study suggests ameliorative role of eugenol and anethole against arsenic induced genotoxic and oxidative damage in cultured human peripheral blood lymphocytes.

scholarly journals Noninvasive Prediction of Prostatic DNA Damage by Oxidative Stress Challenge of Peripheral Blood Lymphocytes

2007 ◽  
Vol 16 (9) ◽  
pp. 1906-1910 ◽  
Author(s):  
David J. Waters ◽  
Shuren Shen ◽  
Huiping Xu ◽  
Seema S. Kengeri ◽  
Dawn M. Cooley ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals Influence of dietary fish oil supplementation on DNA damage in peripheral blood lymphocytes of nine healthy dogs

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Francisco J. Pellegrino ◽  
Analía Risso ◽  
Yanina Corrada ◽  
Rocío C. Gambaro ◽  
Analía I. Seoane
Keyword(s):  
Dna Damage ◽  
Fish Oil ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Dietary Fish ◽  
Healthy Dogs ◽  
Fish Oil Supplementation

scholarly journals Analysis of 177Lu-DOTA-Octreotate Therapy-Induced DNA Damage in Peripheral Blood Lymphocytes of Patients with Neuroendocrine Tumors

2015 ◽  
Vol 56 (4) ◽  
pp. 505-511 ◽  
Author(s):  
D. Denoyer ◽  
P. Lobachevsky ◽  
P. Jackson ◽  
M. Thompson ◽  
O. A. Martin ◽  
...  
Keyword(s):  
Dna Damage ◽  
Neuroendocrine Tumors ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes
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