Response to Vitamin D Supplementation in Inflammatory Bowel Disease Patients with Vitamin D Deficiency: A Tertiary Care Center Experience

2012 ◽  
Vol 107 ◽  
pp. S672
Author(s):  
April Jorge ◽  
Manie Juneja ◽  
Aimee LeStrange ◽  
Thuc Quyen Nguyen ◽  
John Hawes ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Care Center ◽  
Tertiary Care ◽  
Vitamin D Supplementation ◽  
Tertiary Care Center ◽  
Inflammatory Bowel

scholarly journals Managing vitamin D deficiency in inflammatory bowel disease

2019 ◽  
Vol 10 (4) ◽  
pp. 394-400 ◽  
Author(s):  
Ole Haagen Nielsen ◽  
Thomas Irgens Hansen ◽  
John Mark Gubatan ◽  
Kim Bak Jensen ◽  
Lars Rejnmark
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
Vitamin D Supplementation ◽  
Disease Outcomes ◽  
Immunological Effects ◽  
Inflammatory Bowel

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

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