scholarly journals S3387 Correlation Study of Non Alcoholic Fatty Liver Disease (NAFLD) Severity With Cardiometabolic Disorders in Subjects Undergoing Health Check-Up in New Delhi, India

2021 ◽  
Vol 116 (1) ◽  
pp. S1393-S1394
Author(s):  
Swapnil D. Khose
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Correlation Study ◽  
Health Check ◽  
New Delhi ◽  
Alcoholic Fatty Liver ◽  
Cardiometabolic Disorders ◽  
Alcoholic Fatty Liver Disease

scholarly journals New Era for Usage of Serum Liver Enzymes as A Promising Horizon for the Prediction of Non-Alcoholic Fatty Liver Disease

2016 ◽  
Vol 4 (3) ◽  
pp. 348-352 ◽  
Author(s):  
Ahmed Abd Allah Salman ◽  
Soheir Abd Elfattah Aboelfadl ◽  
Mona Abd Elmenem Heagzy
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Significant Positive Correlation ◽  
Liver Enzymes ◽  
Correlation Study ◽  
Alcoholic Fatty Liver ◽  
Cutoff Value ◽  
Positive Correlation ◽  
Alcoholic Fatty Liver Disease

BACKGROUND: Liver histology remains the gold standard for assessing non-alcoholic fatty liver disease (NAFLD). Noninvasive serological markers and radiological methods have been developed to evaluate steatosis to avoid biopsy.AIM: To put cutoff value for liver enzymes that could predict non-alcoholic steatohepatitis (NASH).PATIENTS AND METHODS: This study was conducted on 54 patients (with NAFLD diagnosed by the US). Patients were subjected to history, physical, anthropometric measurements, investigations including liver enzymes, abdominal US, and liver biopsy. According to biopsy results, patients were subdivided according to NASH development. Also, biopsy results were correlated to the levels of liver enzymes.RESULTS: Forty-seven patients who were suspected to have NAFLD by sonar were confirmed by biopsy. There was a significant correlation between steatosis degree in biopsy and sonar. Correlation study between steatosis in biopsy and ALT level showed highly significant positive correlation. Correlation study between steatosis in biopsy on one side & AST and GGT on the other side showed significant positive correlation. Cutoff value for detection of NASH using ALT & AST & and GGT were 50.5, 56, 60.5 respectively with sensitivity = 95.5, 90.5, 86.4 % and specificity = 93.8, 100, 87.5%. CONCLUSION: Cut off values of liver enzymes can be combined with abdominal sonar to predict NASH.

scholarly journals The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study

2020 ◽  
Vol 4 ◽  
pp. 100097
Author(s):  
Ehimen C. Aneni ◽  
Marcio Sommer Bittencourt ◽  
Catherine Teng ◽  
Miguel Cainzos-Achirica ◽  
Chukwuemeka U. Osondu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Longitudinal Study ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Cardiometabolic Disorders ◽  
Alcoholic Fatty Liver Disease

scholarly journals The role of non-alcoholic fatty liver disease in the development of cardiovascular diseases

2018 ◽  
Vol 9 (1) ◽  
pp. 47-53
Author(s):  
R. A Eganyan
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Main Role ◽  
Alcoholic Fatty Liver ◽  
Cardiometabolic Disorders ◽  
Excessive Body Weight ◽  
Alcoholic Fatty Liver Disease

The review describes the pathogenetic mechanisms of the relationship between cardiovascular disease and non-alcoholic fatty liver disease (NAFLD), which is the rationale for selecting therapeutic targets for intervention. The role of insulin resistance, oxidative stress, inflammation, dyslipidemia, intestinal microflora, heredity in the pathological relationship between NAFLD and cardiometabolic disorders are discussed. Present-day data of domestic and foreign scientists on prevalence, etiology, pathogenesis, clinical picture and treatment of this comorbid state are presented. Information is given on the development of subclinical and clinical atherosclerosis, as well as the concept of the hepatocardial continuum. In the treatment of NAFLD, the main role is given to the elimination or correction of etiopathogenetic factors of the development of the disease, excessive body weight, obesity, insulin resistance, hyperglycemia, hyperlipidemia. Particular attention is paid to the issues of dietetic complex intervention and the influence of various nutrition components on the state of the cardiovascular system and the liver.

scholarly journals Cardiometabolic risk factors in different clinicomorphological stages of non-alcoholic fatty liver disease in patients with abdominal obesity

2012 ◽  
Vol 9 (3) ◽  
pp. 20-25
Author(s):  
K A Komshilova ◽  
E A Troshina ◽  
S A Butrova ◽  
P O Bogomolov ◽  
A P Knyazeva
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Abdominal Obesity ◽  
Fatty Liver Disease ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Alcoholic Fatty Liver ◽  
Cardiometabolic Disorders ◽  
Alcoholic Fatty Liver Disease

The aim of the study was to compare clinical, laboratory and morphological parameters in patients with abdominal obesity and non-alcoholic fatty liver disease (NAFLD), and assessing the relationship between the degree of severity, stage NAFLD and cardiometabolic risk factors for type 2 diabetes mellitus and cardiovascular disease. The present study examined the content of adiponectin and rates of glucose and lipid metabolism in obese patients at different stages of NAFLD. According to the study, morphologically NAFLD was confirmed in 95.2% of patients. NAFLD was associated with various cardiometabolic disorders (dyslipidemia, disorders of glucose metabolism and insulin resistance), growing in frequency and severity with the progression NAFLD; and low levels of adiponectin decreasing with a deterioration NAFLD.

Comorbid patient with non-alcoholic fatty liver disease

2020 ◽  
pp. 32-37
Author(s):  
Elena N. Shirokova ◽  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Cardiac Arrhythmias ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Cardiometabolic Disorders ◽  
Pleiotropic Properties ◽  
Alcoholic Fatty Liver Disease

The article reviews the evidence for an association between non-alcoholic fatty liver disease (NAFLD) and multiple cardiometabolic disorders, including ischemic stroke, insulin resistance, arterial hypertension, dyslipidemia, chronic kidney disease and cardiac arrhythmias and outlines the mechanisms that underpin this relationship. The role of ursodeoxycholic acid, a drug with pleiotropic properties, in the treatment of NAFLD has been shown.

Sign in / Sign up

Export Citation Format

Share Document