scholarly journals Ultrasonographic study of common carotid arteries in adolescents with type 1 diabetes mellitus

2009 ◽  
Vol 12 (1) ◽  
pp. 36-38
Author(s):  
Viktoriya Nikolaevna Panfilova ◽  
A Ya Panfilov ◽  
S N Doroshchenko ◽  
T E Taranushenko
Keyword(s):  
Diabetes Mellitus ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Control Group ◽  
Chronic Complications ◽  
Stiffness Coefficients ◽  
Type1 Diabetes ◽  
Common Carotid Arteries ◽  
Type1 Diabetes Mellitus

Aim. To elucidate sonographic characteristics of common carotid arteries in adolescents with type1 diabetes mellitus (DM1) depending on the duration of the disease and thepresence of chronic complications. Materials and methods. A total of 56 adolescents having DM1 of different duration were examined to evaluate conditions of common carotid arteries (CA) in the systole anddiastole during at least 3 cardiac cycles. The following parameters were measured: CA diameter, intima-media thickness (IMT), estimated stretch and stiffness coefficients, Youngsmodulus. The control group comprised 16 healthy adolescents. Results. Bilateral increase of IMT was recorded in patients with DM duration over 5 years. Youngs modulus, stretch and stiffness coefficients were virtually unrelated to diseaseduration. In patients having DM for more than 10 years, stretch coefficient was 5.38 (95% DI 4.82-5.8) compared with 5.82 (95% DI 5.63-7.38) in those with DM for less than 3years (p = 0.04). The level of albuminuria correlated with IMT (r=0.32, p=0.03), stiffness coefficient (r = 0.43, p=0.001), stretch coefficient (r= -0.48, p

scholarly journals Identifying risk factors for development of diabetic ketoacidosis in type 1 diabetes mellitus

2019 ◽  
Vol 6 (2) ◽  
pp. 769
Author(s):  
G. Anand Kumar ◽  
Rajendran . ◽  
Swaminathan .
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Ketoacidosis ◽  
Tertiary Care ◽  
Treatment Protocol ◽  
First Episode ◽  
Treatment Protocols ◽  
Type1 Diabetes ◽  
Type1 Diabetes Mellitus

Background: DKA [ Diabetic keto acidosis] It is the commonest cause of diabetes-related death in children. Children with diabetic ketoacidosis at diagnosis have poorer glycemic control, to identify the risk factors for the development of Diabetic Ketoacidosis in Type1 Diabetes Mellitus in a tertiary care center.Methods: The study was conducted in Kovai Medical Centre And Hospital Coimbatore in 2018.22 children were included in present study. Each consultant followed different standard DKA treatment protocols. The two protocols used were Milwaukee and BSPED guidelines.Results: Among the 22 children, 3 children (13%) had recurrent DKA (>1 episode). One child had his third episode and the rest 2 children had their second episode.19 children had their first episode of DKA.Conclusions: There was no death among the 22 children treated. This was because of the care is given by the team of doctors and adherence to treatment protocol (Milwaukee or BSPED) of DKA.

scholarly journals Presence of metabolic syndrome does not influence intima-media thickness and interadventitial diameter of main arteries in patients with type 2 diabetes mellitus

2018 ◽  
Vol 99 (2) ◽  
pp. 235-239
Author(s):  
R A Rzaeva
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Wall Stiffness ◽  
Common Carotid Arteries

Aim. To evaluate intima-media thickness, interadventitial diameter of common carotid arteries and their ratio in patients with type 2 diabetes mellitus as well as in combination with metabolic syndrome, previously not receiving statins. Methods. The results of Doppler ultrasound of common carotid arteries of 233 patients were analyzed. 73 of them were diagnosed with type 2 diabetes (49 males, 24 females, average age 59.2±9.13 years), 74 - in combination with metabolic syndrome (38 males, 36 females, average age 61.38±9.16 years), and 86 did not have neither type 2 diabetes nor metabolic syndrome (52 males and 34 females, average age 58.99±7.23 years). For variables with normal distribution, mean value (M) and error of mean (m) were used, and when comparing nonparametric parameters, distribution in contingency table and χ2 was used. Results. Mean values of intima-media thickness of common carotid arteries and the ratio of intima-media thickness to interadventitial diameter were significantly higher (p <0.05), and interadventitial diameter was significantly lower (p <0.05) in the subgroups of patients with type 2 diabetes alone and in combination with metabolic syndrome compared to patients without these diseases. Significantly more frequently the cases of increased intima-media thickness and decreased interadventitial diameter of common carotid arteries were revealed on both sides in the subgroups with type 2 diabetes alone and combined with metabolic syndrome (p <0.001), that resulted in increased ratio of intima-media thickness to interadventitial diameter being indicative of general increase of arterial wall stiffness and decreased ability to compensatory remodeling in these categories of patients. Conclusion. In patients with type 2 diabetes mellitus and its combination with metabolic syndrome previously not receiving statins, the values of intima-media thickness, interadventitial diameter and their ratio statistically significantly differ frome those in patients without type 2 diabetes and metabolic syndrome; the presence of metabolic syndrome does not influence values of intima-media thickness, interadventitial diameter and their ratio in patients with type 2 diabetes mellitus.

scholarly journals OMENTIN METABOLISM AND PATHOPHYSIOLOGICAL RELATIONSHIP BETWEEN ITS LEVEL AND THE SEVERITY OF LESIONS IN THE INTIMA-MEDIA THICKNESS OF THE CAROTID ARTERIES IN TYPE 2 DIABETES MELLITUS IN COMBINATION WITH OBESITY

2020 ◽  
pp. 24-27
Author(s):  
Roman Kulynych ◽  
Olena Soloviuk ◽  
Oleksandr Soloviuk
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Media Thickness

The relationship of visceral obesity and excess body weight (EBW) with the development of cardiovascular diseases, type 2 diabetes mellitus (DM) and effect on quality and duration of life determine the relevance of studying this problem. The aim: to assess omentin-1 metabolism and pathophysiological relationship between its level and the severity of lesions in the intima-media thickness (IMT) of the carotid arteries in type 2 DM in combination with EBW and obesity. Materials and methods. We examined 98 people with DM, the first group consisted of 64 people with EBW and obesity, second group consisted of 34 people with normal body weight, control group – 28 healthy individuals. The concentration of omentin-1 was investigated by ELISA by solid-phase enzyme-linked immunosorbent assay in vitro. Ultrasound of the carotid arteries was performed in the lying position of the patient on the device MyLab50X with a linear sensor of 7 MHz with a slight deviation of the patient's head in the opposite direction. Results. Evaluation of the correlation matrix showed the presence of a positive rather strong negative connection between IMT, especially the right carotid artery and the level of omentin-1 in the blood (Rs = –0.55; p = 0.002). The largest number of individuals with omentin-1 levels from 5–10 ng / ml had significant disorders of the vascular wall (IMT from 1.0 to 1.2 mm). Conclusion. Obtained data indicate a statistically significant associative relationship between the dynamics of the predictor of cardiovascular risk – IMT with the degree of impaired expression of omentin-1.

scholarly journals Assessment of carotid intima-media thickness in patients with type 2 diabetes mellitus and arterial hypertension

2014 ◽  
Vol 17 (1) ◽  
pp. 41-46
Author(s):  
Irina Arkad'evna Bondar' ◽  
Alexander Aristarkhovich Demin ◽  
Olesya Yur'evna Shabel'nikova ◽  
Viktoriya Alexandrovna Onyanova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Hypertension ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Common Carotid Arteries

Aim.  Atherosclerosis is one of the most important complications of type 2 diabetes mellitus (T2DM). In the present study, we aimed to assess the carotid intima-media thickness in type 2 diabetes patients with the arterial hypertension (AH) comorbidity. Materials and Methods.  96 patients with T2DM and AH (30M/66F, aged 53.4?5.4 years, duration of diabetes 7.7?7.5 years) and 30 hypertensive patients without diabetes (12M/18F, aged 53.1?6.0 years) were enrolled in this study. Stiffness indices for right and left common carotid arteries were assessed with noninvasive ultrasound method in both groups. Results. Difference in the intima-media thickness was statistically significant between diabetic and euglycemic patients (1.26?0.17 mm vs. 1.10?0.14 mm, respectively; p0.05), in contrast with their counterparts with longer experience of T2DM (1.27?0.17 mm vs. 1.10?0.14 mm; p

scholarly journals Association of insulin gene VNTR INS -23/Hph1 A>T (rs689) polymorphism with type 1 diabetes mellitus in Egyptian children

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Azza M. Kamel ◽  
Marwa F. Mira ◽  
Gamal T. A. Ebid ◽  
Samar H. Kassem ◽  
Eman R. Radwan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Type1 Diabetes ◽  
Susceptibility Factors ◽  
Egyptian Children ◽  
Diabetic Children ◽  
Polymerase Chain ◽  
Type1 Diabetes Mellitus ◽  
Apparently Healthy

Abstract Background Type1 diabetes mellitus (T1DM) has a multi-factorial pathogenesis; the interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. Apart from HLA, more than 50 genetic variants are associated with T1DM. INS -23/Hph1 A>T (rs689) is one of the effective loci with inconsistent reports in the literature. Accordingly, this study was designed to define the frequencies of INS -23/Hph1 A>T polymorphism and its association with T1DM in Egyptian diabetic children and their non-diabetic family members as compared to healthy controls. Methods Using polymerase chain reaction-restriction fragment length polymorphism methodology, analysis of insulin gene VNTR polymorphism was performed for 496 samples (91 patients, 179 parents, 130 siblings, and 96 controls); parents and siblings were apparently healthy. Results INS genotypes and allele frequencies were comparable between patients, non-diabetic siblings, and parents (p = 0.97 and 0.77, respectively). However, the TT/AT genotype and T allele were over-presented in the three family groups compared to controls (p = 0.0015 and 0.0029, respectively). Comparing patients to controls, the T allele is considered a risk factor for the development of TIDM (OR 2.56, 95% CI 1.42–4.62, p = 0.0017). INS -23/Hph1 A>T polymorphism showed concordance between patients and their mothers (Kappa = 0.446, p = 0.000) but not with their fathers (Kappa = 0.031, p = 0.765). Conclusions INS -23/Hph1 A>T gene polymorphism was shown to be a risk factor for the development of TIDM. This is in agreement with some and in disagreement with other reports. Studies of risk susceptibility factors have to be carried out locally in each community; results cannot be extrapolated from one ethnic group to another.

scholarly journals Level and Statistical Distribution of Thyroid Peroxidase and Thyroid Hormones in Iraqi patients with Type1 Diabetes Mellitus at Al-Karkh Side

2016 ◽  
Vol 13 (2) ◽  
pp. 312-319
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Peroxidase ◽  
Diabetic Patients ◽  
Autoimmune Thyroid ◽  
Type1 Diabetes ◽  
Specialized Center ◽  
Significant Difference ◽  
Type1 Diabetes Mellitus

Type 1 diabetes mellitus (T1DM) is an autoimmune disease frequently associated with autoimmune thyroid disease (AITD). The study is conducted at the Specialized Center for Endocrinology and Diabetes-Baghdad at Al-karkh side, during December 2013 up to April 2014. In this study, we investigate the prevalence of anti-thyroid peroxidase (anti-TPO) antibody in(80) type1 diabetic patients with (AITD) and (30) healthy controls .Blood samples are taken for investigation of thyroid tests by using Vitek Immunodiagnstic Assay System (VIDAS).Enzeme Linked Immunosorbent Assay (ELISA) is used to detect anti-thyroid antibody(anti-TPO). The results show that age, gender and BMI (body mass index) are similar in both groups, p>0.05. Among 80 type1 diabetic patients 15(18.8%) are positive. There is a highly significant difference (p0.05) between T3 &T4 and frequency of positive and negative (anti-TPO).

scholarly journals Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1110
Author(s):  
Magdalena Łukawska-Tatarczuk ◽  
Edward Franek ◽  
Leszek Czupryniak ◽  
Ilona Joniec-Maciejak ◽  
Agnieszka Pawlak ◽  
...  
Keyword(s):  
Global Longitudinal Strain ◽  
Thyroid Volume ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Left Ventricular ◽  
Sirtuin 1 ◽  
Control Group ◽  
Cardiovascular Parameters ◽  
Autoimmune Thyroid

The loss of cardioprotection observed in premenopausal, diabetic women may result from the interplay between epigenetic, metabolic, and immunological factors. The aim of this study was to evaluate the concentration of sirtuin 1, visfatin, and IL-27 in relation to cardiovascular parameters and Hashimoto’s disease (HD) in young, asymptomatic women with type 1 diabetes mellitus (T1DM). Thyroid ultrasound, carotid intima-media thickness (cIMT) measurement, electrocardiography, and echocardiography were performed in 50 euthyroid females with T1DM (28 with HD and 22 without concomitant diseases) and 30 controls. The concentrations of serum sirtuin 1, visfatin and IL-27 were assessed using ELISA. The T1DM and HD group had higher cIMT (p = 0.018) and lower left ventricular global longitudinal strain (p = 0.025) compared to females with T1DM exclusively. In women with a double diagnosis, the sirtuin 1 and IL-27 concentrations were non-significantly higher than in other groups and significantly positively correlated with each other (r = 0.445, p = 0.018) and thyroid volume (r = 0.511, p = 0.005; r = 0.482, p = 0.009, respectively) and negatively correlated with relative wall thickness (r = –0.451, p = 0.016; r = –0.387, p = 0.041, respectively). These relationships were not observed in the control group nor for the visfatin concentration. These results suggest that sirtuin 1 and IL-27 contribute to the pathogenesis of early cardiac dysfunction in women with T1DM and HD.

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus

Open Medicine ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. 415-422
Author(s):  
Kamile Gul ◽  
Ihsan Ustun ◽  
Yusuf Aydin ◽  
Dilek Berker ◽  
Halil Erol ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Statistical Significance ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Thyroid Peroxidase ◽  
The Difference ◽  
Type 1 Dm

AbstractThe aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study. In patients with type 1 DM, positive anti-GAD was detected in 30.8% (n=32). In patients with positive anti-GAD, rate of positive anti-TPO was 37.5%; however, in patients with negative anti-GAD, the rate of positive anti-TPO was 9.7% and the difference was statistically significant (p=0.001). In patients with positive anti-GAD, the rate of positive anti-TG was 18.8%. In patients with negative anti-GAD, the rate of positive anti-TG was 2.8%, and the difference between them was statistically significant (p=0.005). In patients with positive and negative anti-GAD, rates of both positive anti-TPO and anti-TG were 15.6% and 1.4%, respectively, with the difference showing statistical significance (p=0.004). Thyroid autoimmunity in type 1 DM patients with positive anti-GAD was apparently higher; therefore, these patients should be followed more frequently and carefully.

The relationship between carotid intima-media thickness and microvascular changes in retinal zones and optic disc in patients with type 1 diabetes mellitus

2021 ◽  
pp. 112067212110640
Author(s):  
Hafize Gokben Ulutas ◽  
Metin Guclu ◽  
Mehmet Emin Aslanci ◽  
Gokhan Karatas
Keyword(s):  
Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Imt ◽  
Mean Values ◽  
Microvascular Changes ◽  
Capillary Plexus ◽  
The Mean ◽  
Superficial Capillary Plexus

Purpose The aim of this study was to detect early retinal vascular changes with optical coherence tomography angiography (OCTA) in type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy and to evaluate the correlation of the results with carotid intima-media thickness (IMT). Design This is a case–control and cross-sectional study. Methods This study included 38 adult patients with T1DM, and 38 age and gender-matched healthy controls. Retinal and optic disc (OD) measurements were taken using OCTA. The carotid artery IMT of each patient was measured using Doppler ultrasonography. Superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density, foveal avascular zone (FAZ), non-flow area (NFA) and foveal density (FD) were analysed in the fovea centred 6 × 6 mm macular area. The superficial capillary plexus and DCP were also scanned centred on the peripapillary region. The correlations between OCTA measurements and carotid IMT, duration of DM and haemoglobin A1c levels in patients with T1DM were evaluated. Results The mean values for carotid IMT were significantly higher in diabetic patients than in controls ( p < 0.001). The mean values for vessel density SCP, DCP and OD were significantly lower in the diabetic group ( p < 0.05). There were correlations between the carotid IMT and duration of T1DM and the evaluated parameters of OCTA. Conclusion Microvascular changes in the SCP and DCP in patients with T1DM without DR offer important data. OCTA can be used to detect early microvascular changes in patients with T1DM without DR. In addition, a relationship was found between SCP vascular dropout and carotid IMT.

Corneal Sensitivity in Bacterial Keratitis Patients with or without Diabetes Mellitus

2021 ◽  
pp. 67-72
Author(s):  
O. V. Zavoloka
Keyword(s):  
Diabetes Mellitus ◽  
Anterior Segment ◽  
Control Group ◽  
Sensitivity Threshold ◽  
Diabetic Patients ◽  
Bacterial Keratitis ◽  
Corneal Sensitivity ◽  
Fellow Eye ◽  
Nondiabetic Control

The aim. To identify the features of corneal sensitivity of the sick and the fellow eye in bacterial keratitis patients with or without diabetes mellitus. Materials and methods. The analysis was performed on the basis of survey data of 62 type 1 diabetes patients with bacterial keratitis and 43 nondiabetic control patients with bacterial keratitis. The examination was performed at the first visit. In addition to standard ophthalmic examination, the patients underwent fluorescein test, OCT of the anterior segment of the eye, non-contact corneal aesthesiometry. Results and discussion. The average corneal sensitivity threshold in diabetic patients with bacterial keratitis at the first visit at all air flow temperatures exceeded the corresponding indicators in nondiabetic patients of the control group: by 33.5% at an air temperature of 5 °C, by 30.6% at 15 °C, by 28.8% at 20 °C, by 27% at 30 °C, and by 26.1% at 40 °C (p<0.05). The average corneal sensitivity threshold at a temperature of 20 °C in the fellow eye in diabetic patients with bacterial keratitis exceeded that in nondiabetic patients with bacterial keratitis of the control group by 32.9 % (p<0.05). Conclusions. Corneal sensitivity of the sick and fellow eye in patients with bacterial keratitis depends on the presence of diabetes mellitus. The average threshold of corneal sensitivity of the sick and fellow eye in diabetic patients with bacterial keratitis at the first visit exceeds the corresponding values in nondiabetic patients with bacterial keratitis. Keywords: diabetes mellitus, bacterial keratitis, corneal sensitivity.

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