scholarly journals Identifying risk factors for development of diabetic ketoacidosis in type 1 diabetes mellitus

2019 ◽  
Vol 6 (2) ◽  
pp. 769
Author(s):  
G. Anand Kumar ◽  
Rajendran . ◽  
Swaminathan .
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Ketoacidosis ◽  
Tertiary Care ◽  
Treatment Protocol ◽  
First Episode ◽  
Treatment Protocols ◽  
Type1 Diabetes ◽  
Type1 Diabetes Mellitus

Background: DKA [ Diabetic keto acidosis] It is the commonest cause of diabetes-related death in children. Children with diabetic ketoacidosis at diagnosis have poorer glycemic control, to identify the risk factors for the development of Diabetic Ketoacidosis in Type1 Diabetes Mellitus in a tertiary care center.Methods: The study was conducted in Kovai Medical Centre And Hospital Coimbatore in 2018.22 children were included in present study. Each consultant followed different standard DKA treatment protocols. The two protocols used were Milwaukee and BSPED guidelines.Results: Among the 22 children, 3 children (13%) had recurrent DKA (>1 episode). One child had his third episode and the rest 2 children had their second episode.19 children had their first episode of DKA.Conclusions: There was no death among the 22 children treated. This was because of the care is given by the team of doctors and adherence to treatment protocol (Milwaukee or BSPED) of DKA.

scholarly journals Diabetic Ketoacidosis at Onset of Type 1 Diabetes: Rates and Risk Factors Today to 15 Years Ago

2019 ◽  
Vol 6 ◽  
pp. 2333794X1987039 ◽  
Author(s):  
Shana Rose Mencher ◽  
Graeme Frank ◽  
Joanna Fishbein
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Public Awareness ◽  
Retrospective Chart Review ◽  
Late Presentation ◽  
New Onset

Diabetic ketoacidosis (DKA) is a serious, potentially lethal complication of type 1 diabetes mellitus that may be present at diagnosis. The aim of this study was to determine factors associated with presentation in DKA in new-onset youth and compare the rate of DKA and risk factors to a similar study 15 years prior. This study was a retrospective chart review of newly diagnosed patients with type 1 diabetes mellitus from 2010 to 2013. Of the 276 patients, 29% presented in DKA, compared with 38% 15 years prior ( P < .002). Those with Medicaid, those misdiagnosed at initial encounter, and those not evaluated by a pediatrician initially were more likely to present in DKA ( P = .002, P = .002, P < .001, respectively). The diagnosis of diabetes was not elicited in one third of patients who ultimately presented in DKA. Pediatricians should be reeducated to ask about polyuria and polydipsia in routine encounters. Furthermore, public awareness initiatives are needed to reduce late presentation in DKA.

Risk factors and predictors of uncontrolled hyperglycemia and diabetic ketoacidosis in children and adolescents with type 1 diabetes mellitus in Jeddah, western Saudi Arabia

2016 ◽  
Vol 9 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Mohamed Hesham Sayed ◽  
Moustafa Abdelaal Hegazi ◽  
Khairyah Abdulwahed ◽  
Khairya Moussa ◽  
Basem Salama El-Deek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 1 Diabetes ◽  
Saudi Arabia ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Diabetic Ketoacidosis

Electrocardiographic Changes in Type-1 Diabetes Mellitus Children with Diabetic Ketoacidosis Presenting to Tertiary care Hospital, Karachi

2021 ◽  
Vol 15 (11) ◽  
pp. 3340-3342
Author(s):  
Irum Rafique ◽  
Roshia Parveen ◽  
Zubair Khoso ◽  
Shazia Mahar ◽  
Versha Rani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Ecg Changes ◽  
Electrocardiographic Changes

Introduction: Cardiac arrhythmias and arrest have been described in children with diabetic ketoacidosis and generally have been presumed to be caused by electrolyte abnormalities. The rationale of this study was to assess the role and importance of ECG monitoring, as a simple, quick, non-invasive and readily available tool in the diagnosis and confirmation of hypokalemia and hyperkalemia in patients with DKA in the Emergency Department Objective: To Assess the Frequency of electrocardiographic changes in Type-1 diabetes mellitus children with diabetic ketoacidosis presenting to tertiary care hospital, Karachi. Materials and Methods: This retrospective cross sectional study was carried out at the department of pediatric medicine, NICH Karachi. At the time of presentation, the standard 12-lead ECG was recorded by a single pediatric cardiologist having more than 2 years of experience, QT and RR intervals were measured. Three separate measurements were obtained from each ECG, and the mean of these measurements was used as the value for QTC. QTC of at least 0.45s (450ms) was considered as prolonged QTC. QTD was also assessed at the same time and QTD>50 ms was considered as prolonged QTD. Results: One hundred cases of T1DM with DKA were included in this study. Average age of children was 7.9 ±3.5 years (Min – Max = 0.5 – 14 years), male to female ratio was 1: 0.96. Prolong QTc and QTd interval was observed in (56%) and (38%) children respectively, Mean (±SD) QTc and QTd interval was 449.4 ±36.6 mc and 39.3 ±16.1 mc respectively. While ECG changes were found in (58%) cases. Association between ECG changes and the cases with higher RBS (>350 mg/dl) was statistically significant 81 (81%) cases with ECG changes had higher RBS (p<0.0001) while ECG changes were statistically similar in both age groups and gender (p-values > 0.05). Conclusion: The frequency of ECG changes was higher in T1DM children with diabetic ketoacidosis. ECG changes was significantly associated with higher RBS (>350 mg/dl). Key words: T1DM, Diabetic Ketoacidosis, ECG, QTc, QTd

scholarly journals Ultrasonographic study of common carotid arteries in adolescents with type 1 diabetes mellitus

2009 ◽  
Vol 12 (1) ◽  
pp. 36-38
Author(s):  
Viktoriya Nikolaevna Panfilova ◽  
A Ya Panfilov ◽  
S N Doroshchenko ◽  
T E Taranushenko
Keyword(s):  
Diabetes Mellitus ◽  
Carotid Arteries ◽  
Intima Media Thickness ◽  
Control Group ◽  
Chronic Complications ◽  
Stiffness Coefficients ◽  
Type1 Diabetes ◽  
Common Carotid Arteries ◽  
Type1 Diabetes Mellitus

Aim. To elucidate sonographic characteristics of common carotid arteries in adolescents with type1 diabetes mellitus (DM1) depending on the duration of the disease and thepresence of chronic complications. Materials and methods. A total of 56 adolescents having DM1 of different duration were examined to evaluate conditions of common carotid arteries (CA) in the systole anddiastole during at least 3 cardiac cycles. The following parameters were measured: CA diameter, intima-media thickness (IMT), estimated stretch and stiffness coefficients, Youngsmodulus. The control group comprised 16 healthy adolescents. Results. Bilateral increase of IMT was recorded in patients with DM duration over 5 years. Youngs modulus, stretch and stiffness coefficients were virtually unrelated to diseaseduration. In patients having DM for more than 10 years, stretch coefficient was 5.38 (95% DI 4.82-5.8) compared with 5.82 (95% DI 5.63-7.38) in those with DM for less than 3years (p = 0.04). The level of albuminuria correlated with IMT (r=0.32, p=0.03), stiffness coefficient (r = 0.43, p=0.001), stretch coefficient (r= -0.48, p

scholarly journals Association of insulin gene VNTR INS -23/Hph1 A>T (rs689) polymorphism with type 1 diabetes mellitus in Egyptian children

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Azza M. Kamel ◽  
Marwa F. Mira ◽  
Gamal T. A. Ebid ◽  
Samar H. Kassem ◽  
Eman R. Radwan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Type1 Diabetes ◽  
Susceptibility Factors ◽  
Egyptian Children ◽  
Diabetic Children ◽  
Polymerase Chain ◽  
Type1 Diabetes Mellitus ◽  
Apparently Healthy

Abstract Background Type1 diabetes mellitus (T1DM) has a multi-factorial pathogenesis; the interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. Apart from HLA, more than 50 genetic variants are associated with T1DM. INS -23/Hph1 A>T (rs689) is one of the effective loci with inconsistent reports in the literature. Accordingly, this study was designed to define the frequencies of INS -23/Hph1 A>T polymorphism and its association with T1DM in Egyptian diabetic children and their non-diabetic family members as compared to healthy controls. Methods Using polymerase chain reaction-restriction fragment length polymorphism methodology, analysis of insulin gene VNTR polymorphism was performed for 496 samples (91 patients, 179 parents, 130 siblings, and 96 controls); parents and siblings were apparently healthy. Results INS genotypes and allele frequencies were comparable between patients, non-diabetic siblings, and parents (p = 0.97 and 0.77, respectively). However, the TT/AT genotype and T allele were over-presented in the three family groups compared to controls (p = 0.0015 and 0.0029, respectively). Comparing patients to controls, the T allele is considered a risk factor for the development of TIDM (OR 2.56, 95% CI 1.42–4.62, p = 0.0017). INS -23/Hph1 A>T polymorphism showed concordance between patients and their mothers (Kappa = 0.446, p = 0.000) but not with their fathers (Kappa = 0.031, p = 0.765). Conclusions INS -23/Hph1 A>T gene polymorphism was shown to be a risk factor for the development of TIDM. This is in agreement with some and in disagreement with other reports. Studies of risk susceptibility factors have to be carried out locally in each community; results cannot be extrapolated from one ethnic group to another.

scholarly journals Level and Statistical Distribution of Thyroid Peroxidase and Thyroid Hormones in Iraqi patients with Type1 Diabetes Mellitus at Al-Karkh Side

2016 ◽  
Vol 13 (2) ◽  
pp. 312-319
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Peroxidase ◽  
Diabetic Patients ◽  
Autoimmune Thyroid ◽  
Type1 Diabetes ◽  
Specialized Center ◽  
Significant Difference ◽  
Type1 Diabetes Mellitus

Type 1 diabetes mellitus (T1DM) is an autoimmune disease frequently associated with autoimmune thyroid disease (AITD). The study is conducted at the Specialized Center for Endocrinology and Diabetes-Baghdad at Al-karkh side, during December 2013 up to April 2014. In this study, we investigate the prevalence of anti-thyroid peroxidase (anti-TPO) antibody in(80) type1 diabetic patients with (AITD) and (30) healthy controls .Blood samples are taken for investigation of thyroid tests by using Vitek Immunodiagnstic Assay System (VIDAS).Enzeme Linked Immunosorbent Assay (ELISA) is used to detect anti-thyroid antibody(anti-TPO). The results show that age, gender and BMI (body mass index) are similar in both groups, p>0.05. Among 80 type1 diabetic patients 15(18.8%) are positive. There is a highly significant difference (p0.05) between T3 &T4 and frequency of positive and negative (anti-TPO).

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