scholarly journals Alogliptin – the new member of DPP-4 inhibitors class

2014 ◽  
Vol 11 (4) ◽  
pp. 25-31 ◽  
Author(s):  
Nina Aleksandrovna Petunina ◽  
Anna Leont'evna Terekhova
Keyword(s):  
Diabetes Mellitus ◽  
Adult Patients ◽  
Efficacy And Safety ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Dm Type 2

This review presents data on the efficacy and safety of alogliptin, a new representative of the DPP-4 inhibitors, in adult patients with type2 diabetes mellitus (DM type 2) as monotherapy or in combination with metformin, pioglitazone, glibenclamide and insulin.

Efficacy and safety of autoprobiotic therapy in patients with type 2 diabetes mellitus

2020 ◽  
Vol 1 (30) ◽  
pp. 48-53
Author(s):  
V. I. Simanenkov ◽  
N. V. Bakulina ◽  
S. V. Tikhonov ◽  
E. I. Ermolenko ◽  
V. D. Dekkanova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Intestinal Microbiota ◽  
Efficacy And Safety ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Dm Type 2 ◽  
Qualitative Characteristics

The original article presents the results of a study in which 12 patients with DM type 2 received 14-day therapy with an industrial probiotic (E. faecium L3 strains) or autoprobiotic (patient's own E. faecium). Therapy with the industrial probiotic and autoprobiotic had approximately the same effect on the severity of gastroenterological complaints and the quantitative/qualitative characteristics of the intestinal microbiota. In the group of E. faecium autostrain, there was a significant decrease of C-reactive protein.

scholarly journals Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study

2009 ◽  
Vol 12 (3) ◽  
pp. 79-84
Author(s):  
Ch S Yang ◽  
S Guler ◽  
Marina Vladimirovna Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Basal Insulin ◽  
Two Phase ◽  
Acting Insulin ◽  
Type2 Diabetes ◽  
Previously Treated ◽  
The Difference ◽  
Long Acting ◽  
Type2 Diabetes Mellitus

Aim. To evaluate efficiency and safety of intensification of therapy by substituting two-phase insulin aspart 30 (DiAsp 30) for basal insulin in patients with type2 diabetes mellitus after a failure to achieve target glycemia. Materials and methods. Analysis of the data obtained in a group of patients involved in the PRESENT study (Physicians Routine Evaluation of Safety andEfficacy of NovoMix 30 Therapy), a 6 month-long observational study conducted in 15 countries. The subanalysis included patients previously treated with along-acting insulin analog (AB, n=34) or intermediate and long-acting human basal insulin (HB, n=3414) and transferred thereafter to DiAsp 30 therapy.End-points of efficiency were the difference between blood HbА1c and glucose (fasting and postprandial) levels measured at the onset of the study and upon itscompletion, the number of hypoglycemic episodes and adverse events, physician and patients content with the results of the treatment. End-points were consideredseparately with reference to preceding basal therapy (AB or HB). Results. Treatment with DiAsp 30 for 6 months resulted in a fall of HbА1c levels compared with initial values (-1,60 and -142% in AB and HB patients respectively,p

scholarly journals STUDY OF THYROID FUNCTION IN TYPE 2 DIABETES MELLITUS PATIENTS OF MALWA REGION.

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Deepasha Shahi Bagzai ◽  
Darshna Jain ◽  
Anurag Kesarwani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Diabetic Patients ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Tsh Levels

Background: Thyroid disorders and diabetes mellitus are two common endocrine disorders that are commonly encountered in clinical practice.  The relationship between thyroid disease and diabetes is important for physicians to understand in order to provide the best treatment for both conditions. The aim of this study was to assess thyroid function in Type2 Diabetes Mellitus patients of malwa region and raise awareness about thyroid dysfunction in newly diagnosed T2DM patients. Methods: In this case control study, a total of 200 subjects were chosen. Group I consisted of 100 diagnosed type 2 diabetes cases and Group II 100 sex matched stable controls. After receiving informed consent, patients were enrolled. Thyroid dysfunction in Type2 diabetes mellitus was assessed using biochemical parameters such as fasting plasma glucose, total triiodothyronine T3, total thyroxine T4, and thyroid stimulating hormone (TSH). Results: When diabetic patients were compared to healthy controls, their fasting blood glucose and serum TSH levels were substantially higher. In these two classes, however, there was no substantial difference in serum T3 and T4 levels. The findings suggest that diabetic patients have subclinical hypothyroidism as opposed to the control group in the study population Conclusion: From this current study it has been observed that thyroid function levels were altered in Diabetes mellitus patients, especially TSH levels. so it is suggested that diabetes mellitus patients should be screened for thyroid function studies on a regular basis to prevent further complications of thyroid dysfuction. Keywords: Type 2 diabetes mellitus, Thyroid dysfunction.

EFFICACY OF PRANAYAMIC BREATHING ON COGNITION AND INSTRUMENTAL ACTIVITIES OF DAILY LIVING IN TYPE2 DIABETES MELLITUS.

2021 ◽  
pp. 36-39
Author(s):  
Manju Unnikrishnan ◽  
Titto Cherian
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Instrumental Activities ◽  
Type2 Diabetes ◽  
Conventional Physiotherapy ◽  
Type2 Diabetes Mellitus ◽  
Experimental Group

Type 2 diabetes is inherent in poor physical performance and cognitive functions that affect patients' overall performance in their activities of daily living (ADL) (Lindsay et al., 2016) . Diabetes and cognitive dysfunction are linked, according to epidemiological evidence. When compared to adults without type 2 diabetes, adults who develop type 2 diabetes later in life have cognitive decits; psychomotor productivity, executive function, and learning and memory skills are often the most affected(Wrighten et al., 2009; Okereke, 2008.).So this study aims to investigate the. efcacy of pranayamic breathing on cognition and Instrumental Activities of Daily living (IADL) in type2 diabetes mellitus.(DM). Thirty type2 Diabetic patients between 45-65 years of age were selected randomly and were divided into two groups. Group A received pranayama breathing with conventional physiotherapy for 5 days a week for 4 weeks. Group B received conventional physiotherapy. Montreal cognitive assessment scale (MoCA) and Functional activities questionnaire (FAQ) were reported to determine cognition and IADL.Between group comparison of MOCAshowed that the paired difference obtained from pretest to post test in the experimental group was 3.80±0.862 and in the conventional group 1.13±0.352, the effect size was 4.05 and this observed difference was statistically signicant (p<0.001). Between group comparison of FAQ says that the paired difference obtained was 3.33±0.816 for experimental group and 1.80±1.47 for control group. The effect size observed was 1.28 and it was statistically signicant (p=0.002).The ndings of the study show that there is signicant difference between the scores of two groups which concludes , pranayama breathing with conventional physiotherapy has shown signicant improvement in cognition and Instrumental Activities of daily living among Type 2 Diabetes Mellitus..

scholarly journals Non Alcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Mellitus

2019 ◽  
Vol 3 (2) ◽  
pp. 53-59
Author(s):  
Bickram Pradhan ◽  
Denis Peeyush
Keyword(s):  
Diabetes Mellitus ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Type2 Diabetes ◽  
Patients With Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Alcoholic Fatty Liver Disease

Background: The pandemic of obesity and type2-diabetes mellitus has led to a increasing prevalence of Non Alcoholic Fatty Liver Disease (NAFLD) globally, including developing countries. The current epidemic of NAFLD is reshaping the field of hepatology because patients with NAFLD creased risk for not only liver-related morbidity and mortality but also cardiovascular disease. NAFLD also increases the risk of developing diabetes. Hence patients with diabetes need to be screened for the presence of NAFLD and vice-versa. It is of paramount importance to differentiate between simple steatosis from Non Alcoholic Steatohepatitis (NASH), the later being more associated with hepatic as well as extra hepatic complications.  

scholarly journals Circulating levels of asprosin and its association with insulin resistance and renal function in type2 diabetes mellitus and diabetic nephropathy patients

2021 ◽  
Author(s):  
Golnoosh Goodarzi ◽  
Leila Setayesh ◽  
Reza Fadaei ◽  
Mohammad Ebrahim Khamseh ◽  
Fereshteh Aliakbari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Renal Function ◽  
Serum Levels ◽  
Glucose And Lipid Metabolism ◽  
Type2 Diabetes ◽  
Tnf Α ◽  
Patient Groups ◽  
Type2 Diabetes Mellitus

Abstract Introduction : Adipokines have an important role in development and progression of type 2 diabetes mellitus (T2DM) and its complications such as nephropathy. Asprosin is a recently discovered adipokine that involve in glucose metabolism and inflammation process. The present study sought to evaluate asprosin levels in patients with T2DM and T2DM + nephropathy (NP) compared to controls and its relation with markers of insulin resistance, inflammation and renal function. Methods Serum levels of asprosin, adiponectin, IL-6 and TNF-α were measured in 55 control, 54 T2DM and 55 T2DM + NP patients using ELISA kits. Results Asprosin was found to be higher in T2DM (6.73 ± 1.67) and T2DM + NP (7.11 ± 1.54) compared to controls (4.81 ± 1.09) (p < 0.001), while adiponectin indicated a lower concentration in both patient groups compared with controls. Moreover, IL-6 and TNF-α indicated higher levels in both patients group compared with controls. Asprosin indicated a positive correlation with HbA1c, FBG, TC, LDL-C, IL-6 and TNF-α in T2DM group. In the patients with T2DM + NP asprosin positively correlated with BMI, HbA1c, insulin, HOMA-IR, Cr, UAE, IL-6 and TNF-α and inversely correlated with eGFR. Conclusion Higher concentration of asprosin in T2DM and T2DM + NP and its relation with glucose and lipid metabolism, and markers of renal function and inflammation suggested a possible role for this adipokine in the pathogenesis of T2DM and nephropathy.

Polymorphism of Secretary PLA2G2A Gene Associated with Its Serum Level in Type2 Diabetes Mellitus Patients in Northern Iran

2019 ◽  
Vol 19 (8) ◽  
pp. 1192-1197 ◽  
Author(s):  
Safoura Khajeniazi ◽  
Abdoljalal Marjani ◽  
Raheleh Shakeri ◽  
Safoura Hakimi
Keyword(s):  
Diabetes Mellitus ◽  
Serum Level ◽  
Disease Incidence ◽  
Healthy Individuals ◽  
Northern Iran ◽  
Type2 Diabetes ◽  
Normal Individuals ◽  
High Level ◽  
Type2 Diabetes Mellitus

Background: Inflammation may occur in Type2 diabetes mellitus. sPLA2 is among the factors that contribute to the activation of pathways involved in inflammation. Several agents affect serum sPLA2 level, one of which is genetic diversity. Objective: The current study was performed to determine whether there is a relationship between sPLA2 gene (−763C > G) polymorphism and circulating sPLA2 level in patients with Type 2 diabetes. Methods: DNA was extracted from blood samples and used for the amplification of sPLA2 gene using ARMS-PCR. Results: A statistical analysis using SPSS (version 16) revealed a significant correlation between −763C > G sPLA2 gene polymorphisms and the disease incidence in patients with T2DM. Among the three possible genotypes (GG, CC, and CG), CG genotype was found to have a higher frequency(53%) in T2DM patients. GG and CC genotypes frequencies were 20 and 27%, respectively. In healthy individuals, the frequencies of CC, GG, and GC genotypes were 77, 9.8% and 13.2%, respectively). Patients with genotype GG had the highest level of sPLA2. We showed that C>G polymorphism at position– 763 is associated with a high level of sPLA2 in both T2DM patients and healthy individuals. The average of sPLA2 circulating level was (170.48± 84.90), (106.62 ± 74.31), in patients and normal individuals, respectively. Conclusion: Our findings show that sPLA2 serum level is significantly higher in patients with T2DM disease than that in healthy individuals.

PULMONARY FUNCTION PARAMETERS IN TYPE 2 DIABETES MELLITUS AND NON DIABETIC POPULATION IN A SUBURBAN AREA OF TAMILNADU -A COMPARATIVE STUDY

2021 ◽  
pp. 10-11
Author(s):  
Latha. S ◽  
Sanjay Andrew
Keyword(s):  
Diabetes Mellitus ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Test Results ◽  
Limited Information ◽  
Pulmonary Functions ◽  
Type2 Diabetes ◽  
Diabetic Population ◽  
Type2 Diabetes Mellitus

Diabetes Mellitus has a profound incidence all over the world .Complications of diabetes like nephropathy ,neuropathy and retinopathy were well known while changes in the lung as a result of diabetes were with limited information. Methods: About 175 participants with diabetes and 168 non diabetic participants were tested for pulmonary functions using a computerisied spirometer. Pulmonary functions of the two groups were compared using t test . Results: FVC (Forced vital capacity) of diabetic 58.59% while non diabetic it was77.16 %. MMEF(Maximum mid expiratory ow rate) of diabetic was 61.36% while non diabetic it was 90.13%FVC (Forced vital capacity in 3 seconds ) was 31.96% while in diabetic it was 2.76 liters. PEF (Peak expiratory ow rate ) of diabetic was 41.95% while non diabetic it was 68.30%.Conclusion:The pulmonary functions were grossly decreased in Type2 Diabetes mellitus when compared with non diabetic subjects

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