Metabolic disorders in medulloblastoma and acute lymphoblastic leukemia survivors

The childhood cancer morbidity has been steadily increasing over the last few decades. However, the recent more effective complex treatment approaches have led to a dramatic improvements in the survival rate in childhood cancers. Currently many childhood cancer survivors require a life-long follow-up. Therefore, today doctors of various specialties are faced with different long-term consequences after the complex treatment for cancer. Among the various complications metabolic disorders should be eparately identified as risk factors for cardiovascular diseases, which are the most frequent causes of death. This article describes the current understanding of the various metabolic changes in the patients after treatment for medulloblastoma and acute lymphoblastic leukemia in childhood, the mechanisms of their development and treatment issues.

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Long-term negative effects in young cancer survivors: metabolic disorders in the patients after complex treatment for brain tumors and acute lymphoblastic leukemia in childhood and adolescence

Endocrine Abstracts ◽

10.1530/endoabs.34.p183 ◽

2014 ◽

Author(s):

Tatiana Tselovalnikova ◽

Maria Pavlova ◽

Alexey Zilov ◽

Nadezhda Mazerkina ◽

Olga Zheludkova

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Brain Tumors ◽

Cancer Survivors ◽

Metabolic Disorders ◽

Lymphoblastic Leukemia ◽

Childhood And Adolescence ◽

Complex Treatment ◽

Negative Effects

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Longitudinal Changes in Obesity and Body Mass Index Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study

Journal of Clinical Oncology ◽

10.1200/jco.2008.16.3527 ◽

2008 ◽

Vol 26 (28) ◽

pp. 4639-4645 ◽

Cited By ~ 160

Author(s):

Edward G. Garmey ◽

Qi Liu ◽

Charles A. Sklar ◽

Lillian R. Meacham ◽

Ann C. Mertens ◽

...

Keyword(s):

Body Mass Index ◽

Acute Lymphoblastic Leukemia ◽

Childhood Cancer ◽

Body Mass ◽

Cancer Survivor ◽

Comparison Group ◽

Lymphoblastic Leukemia ◽

Childhood Cancer Survivor ◽

Childhood Cancer Survivor Study

Purpose We examined the rate of increase in the body mass index (BMI; kg/m2) after final height attainment in survivors of acute lymphoblastic leukemia (ALL) and a noncancer comparison group. Methods Childhood Cancer Survivor Study (CCSS) is a retrospectively ascertained cohort study that prospectively tracks the health status of adults who were diagnosed with childhood cancer between 1970 and 1986 and a comparison group of siblings. Changes in BMI from baseline enrollment to time of completion of follow-up (mean interval, 7.8 years) were calculated for 1,451 ALL survivors (mean age, 32.3 years at follow-up) and 2,167 siblings of childhood cancer survivors (mean age, 35.9 years). Results The mean BMI of the CCSS sibling comparison group increased with age (women, 0.25 units/yr, 95% CI, 0.22 to 0.28 units; men, 0.23 units/yr, 95% CI, 0.20 to 0.25 units). Compared with CCSS siblings, ALL survivors who were treated with cranial radiation therapy (CRT) had a significantly greater increase in BMI (women, 0.41 units/yr, 95% CI, 0.37 to 0.45 units; men, 0.29 units/yr; 95% CI, 0.26 to 0.32 units). The rate of BMI increase was not significantly increased for ALL survivors who were treated with chemotherapy alone. Younger age at CRT exposure significantly modified risk. Conclusion CRT used in the treatment of childhood ALL is associated with a greater rate of increasing BMI, particularly among women treated with CRT during the first decade of life. Health care professionals should be aware of this risk and interventions to reduce or manage weight gain are essential in this high-risk population.

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Determining transition readiness in Swiss childhood cancer survivors – a feasibility study

BMC Cancer ◽

10.1186/s12885-021-07787-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Maria Otth ◽

Patrick Wechsler ◽

Sibylle Denzler ◽

Henrik Koehler ◽

Katrin Scheinemann

Keyword(s):

Health Care ◽

Cancer Survivors ◽

Childhood Cancer ◽

Childhood Cancer Survivors ◽

Self Management ◽

Transition Readiness ◽

Long Term Follow Up ◽

Time Point

Abstract Background The successful transition of childhood cancer survivors (CCSs) from pediatric to adult long-term follow-up care is a critical phase, and determining the right time point can be challenging. We assessed the feasibility of the use of existing transition readiness tools in the context of the Swiss health care system, assessed partly transition readiness in Swiss CCSs, and compared our findings with Canadian CCSs for which these tools were originally developed. Methods We officially translated the Cancer Worry Scale (CWS) and Self-Management Skill Scale (SMSS) into German and integrated them into this cross-sectional study. We included CCSs attending the long-term follow-up (LTFU) clinic in the Division of Oncology-Hematology, Department of Pediatrics, Kantonsspital Aarau. We used descriptive statistics to describe transition readiness. Results We randomly recruited 50 CCSs aged ≥18 years at participation. The CCSs had a median CWS score of 62 (interquartile range 55–71), indicating a moderate level of cancer-related worry. Despite high self-management skills, some answers showed a dependency of CCSs on their parents. Our experience shows that the CWS and SMSS are easy for Swiss CCSs to use, understand, and complete. The interpretation of the results must take differences in health care systems between countries into account. Conclusions The translated CWS and SMSS are appropriate additional measures to assess transition readiness in CCSs. These scales can be used longitudinally to find the individual time point for transition and the completion by CCSs enables the health care team to individualize the transition process and to support the CCSs according to their individual needs.

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