scholarly journals Effect of I-131 incorporation on male rat reproductive system and the dose-dependent effect

1994 ◽  
Vol 40 (3) ◽  
pp. 45-47
Author(s):  
L. V. Tarasenko ◽  
S. V. Varga ◽  
V. N. Demchenko ◽  
Ye. V. Bolshova ◽  
N. D. Nosenko ◽  
...  
Keyword(s):  
Reproductive System ◽  
Biologically Active ◽  
Male Rats ◽  
Male Rat ◽  
Dependent Effect ◽  
Functional Changes ◽  
System A ◽  
Direct Injury ◽  
Dose Dependent ◽  
Dose Dependent Effect

Radioactive 131Iwas injected in single doses 9.25, 37, and 92.5 kBq to prepubertal (30-day-old) male rats. Iodine incorporation in doses 37 and 92.5 kBq resulted in some functional changes in the reproductive system of mature rats: blood testosterone level increased, its hypothalamic aromatization intensified, and biologically active LH level in the blood dropped. Incorporation of 9.25 kBq of 131-I had no effect on male reproductive system. A possibility of direct injury to rat testicles by 131I incorporation is suggested.

The Dose‐Dependent Effect of Chronic Administration of Haloperidol, Risperidone, and Quetiapine on Sexual Behavior in the Male Rat

2011 ◽  
Vol 8 (12) ◽  
pp. 3345-3353 ◽  
Author(s):  
Xiang Rong Zhang ◽  
Zhi Jun Zhang ◽  
Trisha A. Jenkins ◽  
Wei Rong Cheng ◽  
Gavin P. Reynolds
Keyword(s):  
Sexual Behavior ◽  
Chronic Administration ◽  
Male Rat ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect

2015 ◽  
Vol 20 (6) ◽  
pp. 309-315 ◽  
Author(s):  
Meric Ben Boujema ◽  
Emilie Laboureyras ◽  
Jan Pype ◽  
Baptiste Bessière ◽  
Guy Simonnet
Keyword(s):  
Nitrous Oxide ◽  
Neuropathic Pain ◽  
Pain Relief ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Male Rats ◽  
Dependent Effect ◽  
Pain Hypersensitivity ◽  
Dose Dependent ◽  
Dose Dependent Effect

BACKGROUND: Despite numerous pharmacological approaches, there are no common analgesic drugs that produce meaningful relief for the majority of patients with neuropathic pain. Although nitrous oxide (N2O) is a weak analgesic that acts via opioid-dependent mechanisms, it is also an antagonist of theN-methyl-D-aspartate receptor (NMDAR). The NMDAR plays a critical role in the development of pain sensitization induced by nerve injury.OBJECTIVE: Using the chronic constriction injury of the sciatic nerve in male rats as a preclinical model of neuropathic pain, the first aim of the present study was to evaluate the lowest N2O concentration and the shortest time of N2O postinjury exposure that would produce persistent relief of neuropathic pain. The second aim was to compare the effects of N2O with gabapentin, a reference drug used in human neuropathic pain relief.METHODS: Changes in the nociceptive threshold were evaluated using the paw pressure vocalization test in rats.RESULTS: Among the various N2O concentrations tested, which ranged from 25% to 50%, only 50% N2O single exposure for 1 h 15 min induced a persistent (minimum of three weeks) and significant (60%) reduction in pain hypersensitivity. A single gabapentin dose (75 mg/kg to 300 mg/kg, intraperitoneally) induced an acute (1 h to 1 h 30 min) dose-dependent effect, but not a persistent effect such as that observed with N2O.CONCLUSIONS: These preclinical results suggest that N2O is advantageous for long-lasting neuropathic pain relief after sciatic nerve injury compared with other drugs used in humans such as gabapentinoids or NMDAR antagonists. The present preclinical study provides a rationale for developing comparative clinical studies.

Effects of Low Doses of Caffeine on Aggressive Behavior of Male Rats

2000 ◽  
Vol 86 (3) ◽  
pp. 941-946 ◽  
Author(s):  
Josephine F. Wilson ◽  
Nicole R. Nugent ◽  
Jonathan E. Baltes ◽  
Sayaka Tokunaga ◽  
Tarik Canic ◽  
...  
Keyword(s):  
Social Interaction ◽  
Aggressive Behavior ◽  
Male Rats ◽  
Double Blind Study ◽  
Low Doses ◽  
Double Blind ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Higher Doses ◽  
Dose Dependent Effect

To date, the effect of low doses of caffeine on aggression has not been systematically examined. Doses of caffeine greater than 30 mg/kg appear to reduce social interaction and aggression in all species studied. In a double blind study of the effects of low doses of caffeine on aggression, rats were housed four per cage, and aggressive behavior against an intruder was recorded during baseline and following administration of 2.5, 5, 10, and 20 mg/kg caffeine. Aggressive behavior was significantly increased following administration of the higher doses of caffeine. Doses of 5, 10, and 20 mg/kg caffeine all were effective in increasing pushing behavior, whereas doses of 5 and 10 mg/kg were most effective in increasing boxing behavior, and a dose of 10 mg/kg was significantly more effective than other doses in increasing chasing and roll-tumble-bite behaviors. Based on these results and other published reports, the inverted-U shaped dose-dependent effect of caffeine on aggression appears to apply, with aggressive behavior being most elevated following doses of 5–20 mg/kg caffeine, less elevated following 2.5 mg/kg or 30 mg/kg, and significantly reduced with doses above 40 mg/kg and at doses below 2.5 mg/kg.

scholarly journals Silver‐doped sol‐gel borate glasses: Dose‐dependent effect on Pseudomonas aeruginosa biofilms and keratinocyte function

2021 ◽  
Author(s):  
Shiva Naseri ◽  
Gabriele Griffanti ◽  
William C. Lepry ◽  
Vimal B. Maisuria ◽  
Nathalie Tufenkji ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Sol Gel ◽  
Borate Glasses ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Dose-Dependent Effect of Statins on the Incidence of Acute Kidney Injury After Cardiac Surgery

2011 ◽  
Vol 91 (2) ◽  
pp. 520-525 ◽  
Author(s):  
Salima Mithani ◽  
Michael Kuskowski ◽  
Yelena Slinin ◽  
Areef Ishani ◽  
Edward McFalls ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Injury ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect
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