scholarly journals Silver‐doped sol‐gel borate glasses: Dose‐dependent effect on Pseudomonas aeruginosa biofilms and keratinocyte function

2021 ◽  
Author(s):  
Shiva Naseri ◽  
Gabriele Griffanti ◽  
William C. Lepry ◽  
Vimal B. Maisuria ◽  
Nathalie Tufenkji ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Sol Gel ◽  
Borate Glasses ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Dose-Dependent Effect of Statins on the Incidence of Acute Kidney Injury After Cardiac Surgery

2011 ◽  
Vol 91 (2) ◽  
pp. 520-525 ◽  
Author(s):  
Salima Mithani ◽  
Michael Kuskowski ◽  
Yelena Slinin ◽  
Areef Ishani ◽  
Edward McFalls ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Injury ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

2021 ◽  
pp. 1-12
Author(s):  
Alina Alshevskaya ◽  
Olga Koneva ◽  
Irina Belomestnova ◽  
Julia Lopatnikova ◽  
Irina Evsegneeva ◽  
...  
Keyword(s):  
Biological Effects ◽  
High Expression ◽  
Functional Responses ◽  
Double Positive ◽  
Dependent Effect ◽  
Similar Expression Profile ◽  
Proliferation Response ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Mcf 7

<b><i>Introduction:</i></b> Modulating specific biological effects through the changes in cytokine receptors’ expression level remains poorly understood. This study aimed to investigate the influence of the dose-dependent effect of TNF on the balance between proapoptotic and proliferation response depending on the parameters of TNFR1/2 expression density. <b><i>Methods:</i></b> Tumor cell lines (HEp-2, K-562, MCF-7, ZR-75/1, MOLT-4, IM-9, and Raji) were characterized for TNFR1/2 co-expression using flow cytometry and were studied to reveal the dose-dependent effect of rhTNF on cell cycle and apoptosis parameters. The associations among the studied parameters were estimated by correlation and regression analysis. <b><i>Results:</i></b> It was found for ZR-75/1 cells (the cell line characterized by high expression of both types) that a dose-dependent increase in expression of both types of TNF-α receptors on cells reduces the proliferative activity of cells. For MOLT-4 cells (which are characterized by lower expression), an increase in proliferative response of cells was positively associated with the percentage of both TNFR1<sup>+</sup> and TNFR2<sup>+</sup> cells. However, opposite effects on the cells were shown for the K-562 and MCF-7 lines having a similar expression profile. A similarity (a large percentage of double-positive cells) was revealed for the lines having similar effects (K-562 and ZR-75/1). <b><i>Conclusions:</i></b> High expression of TNF receptor type 1 is not always associated with predominant activation of proapoptotic pathways. However, in the case of simultaneous high expression of both types of receptors, the proportion of double-positive cells is crucial for the activation of either the proapoptotic or proliferation pathways.

scholarly journals Dose-dependent effect of low-intensity pulsed ultrasound on callus formation during rapid distraction osteogenesis

2006 ◽  
Vol 24 (11) ◽  
pp. 2072-2079 ◽  
Author(s):  
Chun Wai Chan ◽  
Ling Qin ◽  
Kwong Man Lee ◽  
Wing Hoi Cheung ◽  
Jack Chun Yiu Cheng ◽  
...  
Keyword(s):  
Distraction Osteogenesis ◽  
Callus Formation ◽  
Pulsed Ultrasound ◽  
Dependent Effect ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Dose Dependent ◽  
Dose Dependent Effect

Effect of Lactobacillus casei and Yogurt Administration on Prevention of Pseudomonas aeruginosa Infection in Young Mice

2001 ◽  
Vol 64 (11) ◽  
pp. 1768-1774 ◽  
Author(s):  
SUSANA ALVAREZ ◽  
CLAUDIA HERRERO ◽  
ELENA BRU ◽  
GABRIELA PERDIGON
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Oral Administration ◽  
Lactobacillus Casei ◽  
Opportunistic Pathogen ◽  
Lung Infection ◽  
Pseudomonas Aeruginosa Infection ◽  
Dose Dependent ◽  
Chronic Pneumonia ◽  
Dose Dependent Effect ◽  
Young Mice

Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.

Dose-Dependent Effect of Octreotide on Insulin Secretion after OGTT in Obesity

1997 ◽  
Vol 49 (1) ◽  
pp. 17-21 ◽  
Author(s):  
A. Bertoli ◽  
R. Magnaterra ◽  
P. Borboni ◽  
M.A. Marini ◽  
A. Barini ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

scholarly journals Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect

2005 ◽  
Vol 129 (6) ◽  
pp. 1242-1249 ◽  
Author(s):  
Eric M. Sievers ◽  
Robert D. Bart ◽  
Leah M. Backhus ◽  
Yuanguang Lin ◽  
Margaret Starnes ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Murine Model ◽  
Cyclooxygenase 2 ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect
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