scholarly journals Controlled attenuation parameter by transient elastography for noninvasive assessment of macrovesicular steatosis in potential living liver donors

2021 ◽  
Author(s):  
Sunyoung Lee ◽  
Kyoung Won Kim ◽  
So Yeon Kim ◽  
Nieun Seo ◽  
Gi-Won Song ◽  
...  
Keyword(s):  
Transient Elastography ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter ◽  
Noninvasive Assessment ◽  
Living Liver Donors ◽  
Macrovesicular Steatosis ◽  
Liver Donors

scholarly journals Validating controlled attenuation parameter in the assessment of hepatic steatosis in living liver donors

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251487
Author(s):  
Dieter Broering ◽  
Mohamed Shawkat ◽  
Ali Albenmousa ◽  
Faisal Abaalkhail ◽  
Saleh Alabbad ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Hepatic Steatosis ◽  
Transient Elastography ◽  
Gamma Glutamyl Transferase ◽  
Controlled Attenuation Parameter ◽  
Predictive Values ◽  
Attenuation Parameter ◽  
Glutamyl Transferase ◽  
Living Liver Donors ◽  
Liver Donors

Introduction Hepatic steatosis (HS) negatively impacts transplant outcomes in living liver donors. To date, liver biopsy is preferred for HS evaluation. This study aims to evaluate the measurement of controlled attenuation parameter (CAP) as a diagnostic tool of HS in living liver donors. Methods Candidates recruited to this study, conducted from April 2016 to February 2020, were potential donors who had undergone transient elastography using Fibroscan® and CAP measurements at liver segments VI and VII, followed by liver biopsy. The HS grades from liver biopsy were classified as S0 (<5%), S1 (5–33%), S2 (33–66%), and S3 (>66%). For CAP, they were S0 (≤218dB/m), S1 (218-249dB/m)), S2 (250-305dB/m)), and S3 (>305dB/m)). The CAP measurements were compared with the liver biopsy results. Results Of the 150 potential donors [male, 73.3%; mean age, 30.0±7.0 years; body mass index (BMI), 24.7±3.5kg/m2], 92 (61.3%) had no or mild HS, while 58 (38.7%) and 10% had moderate to severe HS based on CAP and liver biopsy, respectively. Subjects with moderate to severe HS per CAP were mostly males (0.014), and had higher BMI (p = .006), alanine aminotransferase (ALT) (.001), gamma-glutamyl transferase (.026), and high-density lipoprotein (.008). On multivariate analysis, high ALT (OR, 1.051; 95% CI, 1.016–1.087; p = .004) was a predictor of significant HS. The sensitivity, specificity, positive and negative predictive values of CAP to detect significant HS were 93.3%, 67.4, 24.1%, and 98.9%, respectively. Conclusion The high sensitivity and negative predictive values of CAP make it a good screening test to exclude significant HS in potential living liver donors which, in turn, can help avoid unnecessary liver biopsies.

scholarly journals Predicting Hepatic Steatosis in Living Liver Donors Via Controlled Attenuation Parameter

2018 ◽  
Vol 50 (10) ◽  
pp. 3533-3538 ◽  
Author(s):  
Y.H. Yen ◽  
F.Y. Kuo ◽  
C.C. Lin ◽  
C.L. Chen ◽  
K.C. Chang ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter ◽  
Living Liver Donors ◽  
Liver Donors

Prognostic Value of Controlled Attenuation Parameter by Transient Elastography

2017 ◽  
Vol 112 (12) ◽  
pp. 1812-1823 ◽  
Author(s):  
Ken Liu ◽  
Vincent Wai-Sun Wong ◽  
Keith Lau ◽  
Sienna Du Liu ◽  
Yee-Kit Tse ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Transient Elastography ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter

The clinical value of controlled attenuation parameter for the noninvasive assessment of liver steatosis

2016 ◽  
Vol 36 (12) ◽  
pp. 1860-1866 ◽  
Author(s):  
Giovanna Ferraioli ◽  
Carmine Tinelli ◽  
Annalisa De Silvestri ◽  
Raffaella Lissandrin ◽  
Elisabetta Above ◽  
...  
Keyword(s):  
Liver Steatosis ◽  
Controlled Attenuation Parameter ◽  
Clinical Value ◽  
Attenuation Parameter ◽  
Noninvasive Assessment
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