Biofilms formation and prevention on urinary catheters: a bibliometric analysis

To map the scientific production about biofilms formation and prevention on urinary catheters. It is a bibliometric, exploratory, and descriptive research performed in Web of Science™, in three stages, and utilizing HistCite™ software. In this regard, descriptors “Biofilm*” AND “Urinary Catheter*” were utilized within the period between 1945 and 2016. A total of 329 articles about biofilm on urinary catheter were found from 1985 to 2016. These articles were written by 1,262 authors from 452 institutions located in 50 countries. The relation among the 15 selected articles, the most impacting ones, evidences the existence of experimental researches; most of them was in vitro. The control of biofilm formation on urinary catheters remains as a major challenge in the health area, because new ways are necessary to improve the prevention and minimization of this phenomenon.

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In vitro analysis of green fabricated silver nanoparticles (AgNPs) against Pseudomonas aeruginosa PA14 biofilm formation, their application on urinary catheter

Progress in Organic Coatings ◽

10.1016/j.porgcoat.2020.106058 ◽

2021 ◽

Vol 151 ◽

pp. 106058

Author(s):

Felix LewisOscar ◽

Chari Nithya ◽

Sasikumar Vismaya ◽

Manivel Arunkumar ◽

Arivalagan Pugazhendhi ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Silver Nanoparticles ◽

Biofilm Formation ◽

Urinary Catheter ◽

Vitro Analysis ◽

In Vitro Analysis

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In-vitro Studies on Bacterial Biofilm Formation Using Urinary Catheters

10.47275/0032-745x-s2-012 ◽

2020 ◽

Vol 106 (S2) ◽

Author(s):

Milyani RM ◽

Alhaggagi NA ◽

Aly MM

Keyword(s):

Biofilm Formation ◽

Bacterial Biofilm ◽

In Vitro Studies ◽

Urinary Catheters

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A new urinary catheter design reduces in vitro biofilm formation by influencing hydrodynamics

European Urology Open Science ◽

10.1016/s2666-1683(21)00928-9 ◽

2021 ◽

Vol 32 ◽

pp. S116-S117

Author(s):

A.C. Ionescu ◽

E. Brambilla ◽

M.C. Sighinolfi ◽

R. Mattina

Keyword(s):

Biofilm Formation ◽

Urinary Catheter ◽

Catheter Design

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Novel Antiseptic Urinary Catheters for Prevention of Urinary Tract Infections: Correlation of In Vivo and In Vitro Test Results

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00718-09 ◽

2009 ◽

Vol 53 (12) ◽

pp. 5145-5149 ◽

Cited By ~ 60

Author(s):

Ray Hachem ◽

Ruth Reitzel ◽

Agatha Borne ◽

Ying Jiang ◽

Peggy Tinkey ◽

...

Keyword(s):

Electron Microscopy ◽

Scanning Electron Microscopy ◽

Urinary Tract ◽

Urinary Catheter ◽

Rabbit Model ◽

Urinary Catheters ◽

Tract Infections ◽

Scanning Electron

ABSTRACT Urinary catheters are widely used for hospitalized patients and are often associated with high rates of urinary tract infection. We evaluated in vitro the antiadherence activity of a novel antiseptic Gendine-coated urinary catheter against several multidrug-resistant bacteria. Gendine-coated urinary catheters were compared to silver hydrogel-coated Foley catheters and uncoated catheters. Bacterial biofilm formation was assessed by quantitative culture and scanning electron microscopy. These data were further correlated to an in vivo rabbit model. We challenged 31 rabbits daily for 4 days by inoculating the urethral meatus with 1.0 × 109 CFU streptomycin-resistant Escherichia coli per day. In vitro, Gendine-coated urinary catheters reduced the CFU of all organisms tested for biofilm adherence compared with uncoated and silver hydrogel-coated catheters (P < 0.004). Scanning electron microscopy analysis showed that a thick biofilm overlaid the control catheter and the silver hydrogel-coated catheters but not the Gendine-coated urinary catheter. Similar results were found with the rabbit model. Bacteriuria was present in 60% of rabbits with uncoated catheters and 71% of those with silver hydrogel-coated catheters (P < 0.01) but not in those with Gendine-coated urinary catheters. No rabbits with Gendine-coated urinary catheters had invasive bladder infections. Histopathologic assessment revealed no differences in toxicity or staining. Gendine-coated urinary catheters were more efficacious in preventing catheter-associated colonization and urinary tract infections than were silver hydrogel-coated Foley catheters and uncoated catheters.

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MODIFICATION OF URINARY CATHETERS USING ANTIMICROBIALS FROM STREPTOMYCES SP. ABK 07 FOR URINARY TRACT INFECTION RESISTANCE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i7.25502 ◽

2018 ◽

Vol 11 (7) ◽

pp. 158

Author(s):

Angima Bichanga Kingsley, ◽

Usha R

Keyword(s):

Mechanical Properties ◽

Spectral Analysis ◽

Biofilm Formation ◽

Urinary Catheter ◽

Antimicrobial Properties ◽

Antimicrobial Compound ◽

Urinary Catheters ◽

Streptomyces Sp ◽

Infection Resistance

Objective: The main aim of this study is to prevent biofilm formation by impregnating an antimicrobial on urinary catheter.Methods: Catheter segments were immersed in the antimicrobial compound for impregnation. After 2 h, the segments were removed, sterilized and dried after which mechanical and antimicrobial properties of the catheter segments were determined. The shelf life of the impregnated segments was also ascertained as well as anti-biofilm assay. Spectral analysis (UV & FTIR) was also performed.Results: Impregnation was achieved by immersing catheter segments in antimicrobial compound ensuring it does not affect the catheter texture. The impregnated antimicrobial catheters were able to prevent colonization by common uropathogens Escherichia coli, Proteus, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella, and Candida albicans for up to 12 weeks. Antibiotic impregnation of the catheters did not affect the mechanical properties and did not render it as unfit for insertion. The antimicrobial-impregnated catheter offers a means of reducing biofilm formation and subsequently reducing the infection in long-term urinary catheter users. Spectral analysis was done by UV-Vis and FTIR.Conclusion: Antibiotic impregnation of the catheters did not affect the mechanical properties and did not render it as unfit for insertion. The antimicrobial impregnated catheter offers a means of reducing biofilm formation and subsequently reducing the infection in long-term urinary catheter users.

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Second Prize: Sustained Release Varnish Containing Chlorhexidine for Prevention of Biofilm Formation on Urinary Catheter Surface: In Vitro Study

Journal of Endourology ◽

10.1089/end.2011.0140 ◽

2012 ◽

Vol 26 (1) ◽

pp. 26-31 ◽

Cited By ~ 12

Author(s):

Nandakishore K. Shapur ◽

Mordechai Duvdevani ◽

Michael Friedman ◽

Batya Zaks ◽

Irit Gati ◽

...

Keyword(s):

Sustained Release ◽

Biofilm Formation ◽

Urinary Catheter ◽

In Vitro Study ◽

Vitro Study ◽

Catheter Surface

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Studies on Biofilm Formation by Psuedomonas Aeruginosa in Different Urinary Catheters

10.1101/2021.02.23.432614 ◽

2021 ◽

Author(s):

Emmanuel Asante

Keyword(s):

Growth Rate ◽

Biofilm Formation ◽

Quality Evaluation ◽

Urinary Catheter ◽

Urinary Catheters ◽

Silicone Catheter ◽

Different Types ◽

Necessary Evil ◽

Tract Infections ◽

Healthcare Associated

ABSTRACTUrinary Catheters are the leading cause of healthcare –associated Urinary Tract Infections (UTIs) making their use a necessary evil. Various models and approaches had been developed to help reduce the complications associated with the use of these catheters. This study aimed at investigating how two different types of urinary catheters (Silicone Catheter and Latex Coated Catheter) support biofilm formation of Pseudomonas aeruginosa isolates. The growth rate of the bacteria and the rate of formation of biofilm on each urinary catheter was determined by preparing biofilm assays, ranking them using crystal violet satins and measuring their absorbance using UV-VIS spectrophotometer. A difference in the level of biofilm in the catheters were observed. The differences in the level of biofilm observed in the catheters imply that different catheters may have different susceptibility for the formation of biofilms. The study recommends the assessment of biofilm formation in the quality evaluation of catheters. Also further studies should be done to investigate how different catheter material support biofilm formation and the mechanisms involved.

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MP35-20 A NEW URINARY CATHETER DESIGN REDUCES IN VITRO BIOFILM FORMATION BY INFLUENCING HYDRODYNAMICS

The Journal of Urology ◽

10.1097/ju.0000000000002044.20 ◽

2021 ◽

Vol 206 (Supplement 3) ◽

Author(s):

Andrei Ionescu ◽

Eugenio Brambilla ◽

Maria Chiara Sighinolfi ◽

Roberto Mattina

Keyword(s):

Biofilm Formation ◽

Urinary Catheter ◽

Catheter Design

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Antibiofilm Activity of GlmU Enzyme Inhibitors against Catheter-Associated Uropathogens

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.50.5.1835-1840.2006 ◽

2006 ◽

Vol 50 (5) ◽

pp. 1835-1840 ◽

Cited By ~ 64

Author(s):

Euan Burton ◽

Purushottam V. Gawande ◽

Nandadeva Yakandawala ◽

Karen LoVetri ◽

George G. Zhanel ◽

...

Keyword(s):

Biofilm Formation ◽

Enzyme Inhibitors ◽

Bacterial Colonization ◽

Protamine Sulfate ◽

Surrounding Tissue ◽

Confocal Scanning Laser Microscopy ◽

Antibiofilm Activity ◽

Urinary Catheters ◽

Confocal Scanning Laser

ABSTRACT The colonization of uropathogenic bacteria on urinary catheters resulting in biofilm formation frequently leads to the infection of surrounding tissue and often requires removal of the catheter. Infections associated with biofilms are difficult to treat since they may be more than 1,000 times more resistant to antibiotics than their planktonic counterparts. We have developed an antibiofilm composition comprising an N-acetyl-d-glucosamine-1-phosphate acetyltransferase (GlmU) inhibitor and protamine sulfate, a cationic polypeptide. The antibiofilm activity of GlmU inhibitors, such as iodoacetamide (IDA), N-ethyl maleimide (NEM), and NEM analogs, including N-phenyl maleimide, N,N′-(1,2-phenylene)dimaleimide (oPDM), and N-(1-pyrenyl)maleimide (PyrM), was tested against that of catheter-associated uropathogens. Both IDA and NEM inhibited biofilm formation in Escherichia coli. All NEM analogs showed antibiofilm activity against clinical isolates of E. coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus epidermidis, and Enterococcus faecalis. The combination of oPDM with protamine sulfate (PS) enhanced its antibiofilm activity and reduced its effective concentration to as low as 12.5 μM. In addition, we found that the in vitro inhibitory activity of oPDM-plus-PS-coated silicone catheters against P. aeruginosa and S. epidermidis colonization was superior to that of catheters coated with silver hydrogel. Confocal scanning laser microscopy further confirmed that the oPDM-plus-PS-coated silicone catheters were almost free from bacterial colonization. Thus, a broad-spectrum antibiofilm composition comprising a GlmU inhibitor and protamine sulfate shows promise for use in anti-infective coatings for medical devices, including urinary catheters.

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