scholarly journals Relationship between bone remodeling markers, bone mineral density, and severity of coronary atherosclerosis in men with stable coronary heart disease

2018 ◽  
Vol 12 (1) ◽  
pp. 26-32
Author(s):  
T. A. Raskina ◽  
M. V. Letaeva ◽  
A. V. Voronkina ◽  
E. B. Malyuta ◽  
O. N. Khryachkova ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Coronary Atherosclerosis ◽  
Mineral Density ◽  
Stable Coronary Heart Disease ◽  
Bone Remodeling Markers

scholarly journals SAT0480 ASSESSMENT OF CORONARY ATHEROSCLEROSIS SEVERITY IN MEN WITH CORONARY HEART DISEASE DEPENDING ON BONE MINERAL DENSITY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1196.2-1197
Author(s):  
T. Raskina ◽  
A. Voronkina ◽  
M. Letaeva ◽  
A. Kokov ◽  
M. Elena
Keyword(s):  
Bone Mineral Density ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Hip Fracture ◽  
Bone Mineral ◽  
Coronary Atherosclerosis ◽  
Injury Severity ◽  
Lumbar Vertebrae ◽  
Inverse Correlation ◽  
Mineral Density

Background:Objectives:Assess the severity of coronary atherosclerosis in men with coronary heart disease (CHD) depending on bone mineral density (BMD).Methods:102 of men with verified CHD aged 51-75 (60 .8 ± 6.9) were examined. All patients performed two-energy X-ray absorption of lumbar vertebrae bodies LI-LIV and hip necks (Excell XR-46, Norland, USA) and polyproject coronarangiography (Innova, General Electric, USA). On the basis of results of densitometry on value of T-criterion (the recommendation of ISCD, 2007) estimated BMD condition: normal BMD (T criterion ≥-1), osteopenia (T-criterion from-1 to-2.5) and osteoporosis (OP) (T criterion <-2.5). According to the SYNTAX scale (www.syntaxscore.com), the following degrees of coronary artery (CA) injury severity were isolated to quantify the expression of atherosclerotic injury: low (22 or less), intermediate (23-32) and high (33 or more). According to the result of multispiral computed tomography of CA, calcium index of vessels was determined by the Agatston method using the CaScore program. On the basis of the calcium index value the degree of CA calcinosis was evaluated: 0 - absence of calcinosis, 1-10 - minimal, 11 - 100 - moderate, 101-400 - increased, more than 400 - expressed calcinosis.Results:According to the results of densitometry, patients were found to have 21 patients (20.6%) with normal BMD, 48 (47.0%) - osteopenia and 33 (32.4%) -osteoporosis. Osteopenic syndrome (OPS) was found in 79.4% of men. All patients tested, depending on the degree of CA calcinosis, were distributed as follows: 57.8% of men had pronounced CA calcinosis, 25.5% - increased, 6.9% - moderate, 2.0% - minimal, 7.8% of patients had no CA calcinosis. In a comparative analysis of the degree of coronary calcinosis in men with CHD depending on the T-criterion, it was found that the majority of patients with OPS (69.7% of patients with OP and 60.4% with OPe) had pronounced CA calcinosis. In men with normal BMD, the prevalence of pronounced CA calcinosis (33.3%) was significantly lower than in patients with OPS (p < 0.050). Calcinosis-negative CA was recorded reliably more frequently in patients with normal BMD (28.6%) compared to men with low BMD (p < 0.050). The results of the work demonstrated the relationship of the studied parameters of coronary atherosclerosis expression with densitometry indicators in men with CHD. Thus, the inverse correlation of the BMD at the level of the hip neck with the number of significant stenoses of the spacecraft (r = -0.19; P = 0.045) and the degree of coronary calcinosis (r = -0.23; P = 0.022) and similar dependence of BMD of vertebral bodies LI-LIV with coronary calcinosis degree (r = -0.19; р=0,046). A direct correlation between CA calcinosis and FRAX hip fracture risk (r = 0,24; р=0,018). Inverse correlation of parameters of atherosclerotic damage of CA (number of significant stenoses and degree of calcinosis) with BMD was established, and direct correlation of CA calcinosis degree with risk of hip fracture on FRAX scale in male persons with CHD over 50 years of age was revealed.Conclusion:The findings suggest in favor of likely common mechanisms for developing atherosclerosis with OP and allow coronary calcinosis to be considered as a condition potentially increasing the risk of hip fracture.Disclosure of Interests:None declared

Results of study of biochemical markers of bone metabolism in men with coronary heart disease

2020 ◽  
pp. 39-43
Author(s):  
A. V. Voronkina ◽  
T. A. Raskina ◽  
M. V. Letaeva ◽  
Yu. V. Averkieva ◽  
O. S. Malyshenko ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Coronary Atherosclerosis ◽  
Cathepsin K ◽  
Arterial Calcification ◽  
Mineral Density ◽  
Bone Remodeling Markers

The development of atherosclerosis is closely related to the calcification of the vessel intima and fibrous plaques, being a complex and multifactorial process, in which the markers of bone formation and resorption play an important role. Objective. To study the biochemical markers of bone metabolism in men with stable coronary heart disease (CHD). Material and methods. The study included 102 men with verified CHD. Data were evaluated by densitometry, coronary angiography, multispiral computed tomography, color duplex scanning of brachiocephalic arteries, serum lipids (total cholesterol, triglycerides [TG], high-density [LHD] and low-density lipoprotein cholesterol), concentrationsin the blood of osteocalcin (OC), bone alkaline phosphatase (BAP), cathepsin K and C-telopeptides (CTx). Results. Concentrations of BAP, cathepsin K and CTx in patients with CHD were significantly higher than in men without CHD. The concentration of OC in men with normal bone mineral density was significantly lower than in patients with osteopenic syndrome. There was a direct correlation between OC and antiatherogenic HDL cholesterol and the inverse correlation between OC and TG, CTx and TG. There was no correlation between the level of bone remodeling markers and coronary artery (CA) lesion variant and the severity of coronary atherosclerosis on SYNTAX scale. The correlation analysis did not reveal the connection of biochemical markers of bone metabolism with the severity of coronary atherosclerosis and calcification and thickness of intima-media complex of carotid arteries. Absolute values of bone formation indices (BAP, OC) were significantly higher in patients with severe СA calcification than in patients without signs of calcification. Summary. Increased rates of osteogenesis and osteoresorption characterize the accelerated process of bone metabolism and indicate in favor of high rates of bone loss in men with CHD, which confirms the likelihood of common pathophysiological mechanisms of bone resorption and arterial calcification.

scholarly journals AB0910 SARCOPENIA AND BONE MINERAL DENSITY IN MEN WITH CORONARY HEART DISEASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1757.2-1757
Author(s):  
T. Raskina ◽  
I. Grigoreva ◽  
J. Averkieva ◽  
A. Kokov ◽  
V. Masenko
Keyword(s):  
Bone Mineral Density ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Muscle Mass ◽  
Bone Mineral ◽  
Mineral Density ◽  
Group 3 ◽  
Group 2

Objectives:To examine bone mineral density (BMD) in men with coronary heart disease (CHD), depending on the state of the muscle mass, strength and function.Methods:79 men aged over 50 years with verified CHD were examined (mean age 63 (57; 66) years).The BMD and T-criterion (standart deviation, SD) of the femoral neck and lumbar spine (L1-L4) were evaluated using dual-energy x-ray absorptiometry (DXA) on the Lunar Prodigy Primo bone densitometer (USA). The following reference intervals were used: normal BMD values (T-criterion ≥-1), osteopenia (OPe) (T-criterion from -1 to -2.5), and osteoporosis (OP) (T-criterion <-2.5).To assess muscle mass, the total area (cm2) of the lumbar muscles of the axial section at the level of the 3rd lumbar vertebra (L3) was determined using multispiral computed tomography on a 64-slice computer tomograph “Somatom Sensation 64” (Siemens AG Medical Solution, Germany). The ratio of the obtained index of the area of skeletal muscle to the square of the patient’s growth index determined the “ skeletalmuscular index L3” (SMI). The media considered the threshold value to be 52.4 cm2/m2.Results:The femoral neck BMD in the examined patients was 0.96 (0.89; 1.03) g/cm2, which corresponds to -0.50 (-1.00; 0) SD according to the T-criterion, in the lumbar spine -1.23 (1.11; 1.32) g/cm2and 0.4 (-0.50; 1.20) SD according to the T-criterion.In accordance with the recommendations of the European working group on sarcopenia in Older people (EWGSOP, 2010, 2018), the patients were divided into 3 groups: 31 patients without sarcopenia (group 1), 21 patients with isolated muscle loss (presarcopenia) (group 2) and 27 patients with sarcopenia (group 3).BMD in the femoral neck in the group of patients without sarcopenia was 0.96 (0.72; 1.26) g/cm2, which corresponds to -0.50 (-0.8; 0.2) SD according to the T-criterion, in the lumbar spine – 1.19 (1.10; 1.275) g/cm2and 0.1 (-0.6; 0.8) SD according to the T-criterion. BMD in the femoral neck in the group of patients with presarcopenia (group 2) – 0.995 (0.94; 1.04) g/cm2and -0.3 (-0.70; 0) SD according to the T-criterion, in the lumbar spine – 1.32 (1.24; 1.40) g/cm2and 1.20 (0.50; 1.90) SD according to the T-criterion. In patients with established sarcopenia (group 3), the following indicators of BMD and T-criterion were recorded: 0.95 (0.845; 0.98) g/cm2and -0.60 (-1.40; -0.40) SD and 1.23 (0.085; 1.31) g/cm2and 0.4 (-0.8; 1.1) SD in the femoral neck and lumbar spine, respectively.A comparative analysis of the results of the DXA found that patients with sarcopenia had a significant decrease in the BMD and T-criterion in the femoral neck compared to patients with presarcopenia (p=0.039 and p=0.040, respectively). There were no differences between the groups of patients without sarcopenia and with sarcopenia and presarcopenia (p>0.05).It was found that patients with sarcopenia had significantly lower BMD and T-criterion in the lumbar spine compared to patients with presarcopenia (p=0.017 and p=0.0165, respectively). The values of the BMD and T-criterion in the groups of patients without sarcopenia and with presarcopenia and sarcopenia in the lumbar spine were comparable (p>0.05).Conclusion:The presence of sarcopenia is associated with loss of BMD in the femoral neck and in the lumbar spine. The results obtained confirm the high probability of common pathogenetic links between OP and sarcopenia.Disclosure of Interests:None declared

Bone Mineral Density and Frequency of Coronary Heart Disease

2008 ◽  
Vol 101 (11) ◽  
pp. 1680
Author(s):  
Ertan Yetkin ◽  
Hasan Turhan ◽  
Kubilay Senen
Keyword(s):  
Bone Mineral Density ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Alterations of Bone Metabolism in Patients with Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Sain S. Safarova
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Type I Collagen ◽  
Bone Microarchitecture ◽  
Type I ◽  
Mineral Density ◽  
Bone Remodeling Markers ◽  
Patients With Diabetes

Aim. The study aims to develop a practical model for screening bone turnover state in patients with diabetes and evaluate its clinical usefulness to identify diabetic osteopathy. Materials. The study was conducted in 2015–2017 in the Endocrinology Department of the Therapeutic Clinic of AM University. A total of 235 patients were assessed in the study (98 with T1DM and 137 with T2DM). 89 nondiabetic subjects served as controls. Bone mineral density (BMD) [by dual energy X-ray absorptiometry (DXA)] and serum markers of bone remodeling [aminoterminal propeptide of procollagen type I (P1NP) and c-terminal telopeptide of type I collagen (CTX)], parathyrin, and 25(OH)D were measured in all 235 patients. Results. Our results show that patients with T2DM have lower b-CTx values and relatively higher levels of P1NP, reflecting less pronounced changes in bone metabolism compared to patients with T1DM, regardless of age or duration of the disease. Osteoporosis was detected in 50% of patients with T1DM, compared to 13% of patients with T2DM. Conclusion. In some cases, bone remodeling markers are useful for improving the assessment of the state of bone tissue in early stages of diabetes, while alterations in bone microarchitecture may not always be captured by bone mineral density measurements.

scholarly journals Cardiovascular disease is a risk factor for osteoporosis: a case-control study in Chinese women

2020 ◽  
Author(s):  
Hao Chai ◽  
Jirong Ge ◽  
Li Li ◽  
Jianyang Li ◽  
Yunjin Ye
Keyword(s):  
Bone Mineral Density ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Retrospective Study ◽  
Bone Mineral ◽  
Chinese Women ◽  
Baseline Survey ◽  
Mineral Density ◽  
Age Related

Abstract Background: Osteoporosis and cardiovascular disease (CVD) are age-related diseases. According to some studies, patients with CVD have a higher risk of bone loss. This retrospective study intended to reveal the correlation between osteoporosis and CVD in Chinese women. Although epidemiological evidence has provided evidence of the relationship between the two, it lacks clinical data in southeast China.Methods: The 2873 participants completed the baseline survey from January 2007 to October 2019, and 2496 were included in this retrospective study. We divided all subjects into the osteoporosis group and the non-osteoporosis group based on their bone mineral density. Dual-energy x-ray absorptiometry (DXA) was used to examine bone mineral density. The general information came from the questionnaire survey and medical records. Results: According to the criterion, the osteoporosis group had 799 subjects, with a mean age of 64.19 years. The non-osteoporosis group had 1697 subjects, with a mean age of 61.03 years. Subjects in the osteoporosis group had a significantly higher prevalence of hypertension and coronary heart disease. Besides, there was a higher probability of drinking tea and drinking milk in the osteoporosis group. In correlation analysis, the occurrence of osteoporosis correlated positively with hypertension and coronary heart disease. Logistic regression analysis showed that the odds of osteoporosis was high if participants had hypertension, coronary heart disease, or drank tea and drank milk. Conclusions: This study indicated that patients with osteoporosis had a higher prevalence of CVD in Chinese women, and CVD is one of the hazard factors for osteoporosis.

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