Short-term effect of Tramadol injection on the serum levels of Follicle Stimulating Hormone, Luteinizing Hormone and Testosterone in Male Sahel Goats in Maiduguri, Nigeria

Tramadol is a synthetic analogue of codeine. Its mood elevation property and sex enhancement potentials are the main reason for its abuse. The aim of the study was to determine the short-term effect of tramadol administration on Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Testosterone (TEST) levels in Male Sahel Goats. This was an experimental study conducted from 1st October 2017 to 12th November 2017 at the Livestock Teaching and Research Farm, University of Maiduguri, Maiduguri, Borno State Nigeria involving 20 Male Sahel Goats. The goats were divided in to 4 groups of 5 each; group 1 served as control and groups 2, 3 and 4 were injected intramuscularly with 4 mg/kg (low dose), 8 mg/kg (medium dose) and 12 mg/kg (high dose) of Tramadol respectively. The injections were given intramuscularly, 3 times a week for 4 weeks. Blood samples were collected to determine the serum levels of FSH, LH and TEST at 0, 1 week, 2 weeks, 3 weeks and 4 weeks of tramadol injections. The Mean±SD of the hormones were computed using SPSS 20. The difference in mean was compared using t test and ANOVA with p < 0.05 set for statistical significance. The baseline levels of FSH, LH and TEST in Male Sahel Goat in Maiduguri were 2.91±5.74 Miu/ml, 0.29±0.72 Miu/ml and 3.92±6.39 ng/ml respectively. Only the goats in group 4 showed a significant increase in serum FSH and LH by the 4th week (P=0.01 and 0.03 respectively) while no significant change was noted in the other groups. The was a decline in the level of Testosterone from 1st week through 4th week in all the experimental group but the level in the control group remain fairly constant throughout the experiment. The decline is inversely proportional to the dose of tramadol injection and most marked in group 4.High dose and prolonged used of Tramadol should be avoided because of side effects of Hypergonadotrophic hypogonadism.

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Effects of l-Carnitine on the Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Testicular Tissue Oxidative Stress Levels in Streptozotocin-Induced Diabetic Rats

Journal of Evidence-Based Integrative Medicine ◽

10.1177/2515690x18796053 ◽

2018 ◽

Vol 23 ◽

pp. 2515690X1879605 ◽

Cited By ~ 8

Author(s):

Nourollah Rezaei ◽

Tahereh Mardanshahi ◽

Majid Malekzadeh Shafaroudi ◽

Saeed Abedian ◽

Hamid Mohammadi ◽

...

Keyword(s):

Oxidative Stress ◽

Luteinizing Hormone ◽

Follicle Stimulating Hormone ◽

Serum Levels ◽

Diabetic Rats ◽

Diabetic Group ◽

Control Group ◽

Group Vi ◽

Group I ◽

Stimulating Hormone

The present study was designed to investigate the antioxidant property of l-carnitine (LC) on serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TH) and testis oxidative stress in streptozotocin (STZ)-induced diabetic rats. The rats were divided into the following groups: group I, control; group II, LC 100 mg/kg/d; group III, diabetic; and groups IV to VI, diabetic rats treated with 50, 100, and 200 mg/kg/d of LC, respectively. Daily injections were given intraperitoneally for 7 weeks. At the end of experimental period, after sacrificing the rats, FSH, LH, TH, total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), mitochondrial function (MTT), protein carbonyl (PC), and reactive oxygen species (ROS) levels were measured. STZ caused an elevation of MDA, ROS, and PC ( P < .001) with reduction of GSH, CAT, TAC, and MTT ( P < .001) in the serum levels. Group VI had significantly increased FSH, LH, and TH levels versus the untreated diabetic group ( P < .001). Although groups V and VI significantly decreased MDA ( P < .001), PC ( P < .01), and ROS ( P < .01) compared with the untreated diabetic group; only in group VI, the activity of GSH ( P < .001), CAT ( P < .01), TAC ( P < .001), and MTT ( P < .001) significantly increased. The results of the present study suggest that LC decreased diabetes-induced oxidative stress complications and also improved serum level of FSH, LH, and TH by reducing levels of lipid peroxidation and increasing antioxidant enzymes.

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SHORT-TERM EFFECTS OF CASTRATION AND STARVATION UPON PITUITARY AND SERUM LEVELS OF LUTEINIZING HORMONE AND FOLLICLE STIMULATING HORMONE IN MALE RATS

Acta Endocrinologica ◽

10.1530/acta.0.0700665 ◽

1972 ◽

Vol 70 (4) ◽

pp. 665-675 ◽

Cited By ~ 23

Author(s):

Allen W. Root ◽

R. David Russ

Keyword(s):

Luteinizing Hormone ◽

Adult Male ◽

Follicle Stimulating Hormone ◽

Serum Levels ◽

Male Rats ◽

Serum Concentrations ◽

Short Term ◽

Serum Lh ◽

Total Starvation ◽

Stimulating Hormone

ABSTRACT Serum and pituitary levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured by radioimmunoassay in intact and castrated juvenile (21 days) and adult male rats. The effect of total starvation upon the gonadotrophin response to castration was also investigated in adult animals. In rats castrated at 21 days of age, serum and pituitary levels of LH were elevated by 7 days and increased progressively for 4 weeks. Serum concentrations of FSH also increased within 7 days and remained stable thereafter. Pituitary FSH levels initially declined and then increased. In adult animals serum LH and FSH concentrations increased after castration. Pituitary LH values also increased, while FSH levels remained stable for 14 days after operation. Serum FSH concentrations were consistently decreased in starved-intact animals. Starvation partially inhibited castration-induced release of LH without affecting pituitary LH or FSH synthesis or FSH release.

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Effects on the Secretion of Pituitary Growth Hormone, Thyroid Stimulating Hormone, Luteinizing Hormone and Follicle Stimulating Hormone in Rats Rendered Hyperprolactinaemic by Chronic Treatment with Oestrogen

Australian Journal of Biological Sciences ◽

10.1071/bi9810321 ◽

1981 ◽

Vol 34 (3) ◽

pp. 321 ◽

Cited By ~ 1

Author(s):

GA Smythe ◽

JF Brandstater ◽

RF Vining

Keyword(s):

Growth Hormone ◽

Luteinizing Hormone ◽

Follicle Stimulating Hormone ◽

Chronic Administration ◽

Serum Levels ◽

Thyroid Stimulating Hormone ◽

Significant Inhibition ◽

Male Rat ◽

High Dose ◽

Stimulating Hormone

The induction of hyperprolactinaemia in the male rat following chronic high-dose oestrogen administration over 3 months was associated With a significant inhibition of the secretion of growth hormone (OH) (P < 0�02) thyroid stimulating hormone (TSH) (P < 0�0025), luteinizing hormone (LH) and follicle stimulating hormone (FSH) (both P < 0�01). Acute, but not chronic, administration of bromocriptine (1 mg/kg) to these hyperprolactinaemic animals had the effect of normalizing the serum levels of GH and TSH but not those of LH or FSH. While the effects observed on GH, TSH, LH and FSH following induction of hyperprolactinaemia are likely to be consequential to brain actions of prolactin, the present data do not exclude the possibility of direct actions of oestrogen itself.

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A Newspaper’s Effect on the Strength of Automatic Associations in Memory

Journal of Media Psychology Theories Methods and Applications ◽

10.1027/1864-1105/a000057 ◽

2012 ◽

Vol 24 (1) ◽

pp. 1-8 ◽

Cited By ~ 12

Author(s):

Florian Arendt

Keyword(s):

Treatment Group ◽

Term Effect ◽

Control Group ◽

Implicit Measure ◽

Short Term ◽

Short Term Treatment ◽

Short Term Effect ◽

Automatic Associations ◽

Foreign Nationality ◽

The Impact

A test was done to see if reading a newspaper which consistently overrepresents foreigners as criminals strengthens the automatic association between foreign country and criminal in memory (i.e., implicit cultivation). Further, an investigation was done to find out if reading articles from the same newspaper produces a short-term effect on the same measure and if (1) emotionalization of the newspaper texts, (2) emotional reactions of the reader (indicated by arousal), and (3) attributed text credibility moderate the short-term treatment effect. Eighty-five participants were assigned to one of three experimental conditions. Participants in the control group received short factual crime texts, where the nationality of the offender was not mentioned. Participants in the factual treatment group received the same texts, but the foreign nationality was mentioned. Participants in the emotionalized treatment group received emotionalized articles (i.e., texts which are high in vividness and frequency) covering the same crimes, with the foreign nationality mentioned. Supporting empirical evidence for implicit cultivation and a short-term effect was found. However, only emotionalized articles produced a short-term effect on the strength of the automatic association, indicating that newspaper texts must have a minimum of stimulus intensity to overcome an effect threshold. There were no moderating effects of arousal or credibility pertaining to the impact on the implicit measure. However, credibility moderated the short-term effect on a first-order judgment (i.e., estimated frequency of foreigners of all criminals). This indicates that a newspaper’s effect on the strength of automatic associations is relatively independent from processes of propositional reasoning.

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CHANGES IN SERUM LEVELS OF FOLLICLE STIMULATING HORMONE AND LUTEINIZING HORMONE SHORTLY BEFORE AND AFTER PARTURITION IN RATS

Acta Endocrinologica ◽

10.1530/acta.0.0750491 ◽

1974 ◽

Vol 75 (3) ◽

pp. 491-496 ◽

Cited By ~ 3

Author(s):

Junichi Mori ◽

Hiroshi Nagasawa ◽

Reiko Yanai ◽

Junji Masaki

Keyword(s):

Luteinizing Hormone ◽

Follicle Stimulating Hormone ◽

Serum Levels ◽

Sprague Dawley ◽

Appreciable Change ◽

Serum Lh ◽

Sprague Dawley Rats ◽

Before And After ◽

Average Serum ◽

Stimulating Hormone

ABSTRACT The sequence of changes in the serum levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from 2 days before to 24 h after parturition of primiparous Sprague-Dawley rats was investigated by radioimmunoassay. No appreciable change in average serum FSH levels was observed during 2 days before and 1 h after parturition. After this the levels increased gradually to show a peak at 7 h after parturition and then declined gradually until 24 h after parturition. However, the level at 24 h after parturition was still twice as high as that at parturition (0 h). The average serum LH levels which were low between 2 days before and 1 h after parturition, showed a peak at 7 h and decreased toward 13 h after parturition. The same levels as at parturition were maintained between 13 and 24 h after parturition. The time of surge of either FSH or LH was closely related to the time after parturition. There were some differences between FSH and LH in the patterns of sequence of changes in the serum levels near parturition.

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