scholarly journals The Effect of Mud-Bath Therapy on Bone Status in Rats During Adjuvant Subchronic Arthritis

2012 ◽  
Vol 55 (3) ◽  
pp. 133-137 ◽  
Author(s):  
Helena Živná ◽  
Ljiljana Maric ◽  
Iveta Gradošová ◽  
Klára Švejkovská ◽  
Soňa Hubená ◽  
...  
Keyword(s):  
Bone Markers ◽  
Fracture Load ◽  
Good Effect ◽  
Mineral Density ◽  
Left Femur ◽  
X Ray ◽  
Bone Status ◽  
Male Wistar Rats ◽  
Hot Bath ◽  
Bath Therapy

Introduction: We studied influence of mud-bath on bone status in male Wistar rats with subchronic arthritis. Methods: Arthritis was induced by 2 subplantar injections of Freund’s adjuvans with heat-killed Streptoccocus pyogenes into paw. Groups: intact (int) on chippings; (con) arthritis on chippings; (san38) arthritis on hot sand; (mu38) arthritis on hot mud; (mu21) arthritis on mild mud. Bone mineral density (BMD, g/cm2) was measured by dual energy X-ray absorptiometry and femurs were tested biomechanically. Bone markers osteocalcin (OC), PINP and CTX were analysed in bone. Results: BMD of right femur decreased vs. left in san38 (p = 0.030) and mu38 (p = 0.047). Fracture load of right/left femur (N) decreased in experimental groups, significantly in san38 (p = 0.05). Fracture threshold of neck decreased in right vs. left in experimental groups, but significantly in san38 (p = 0.05). OC decreased in mu38 vs. con (1.84 ± 0.14/2.62 ± 0.23). PINP decreased in int vs. san38 (p = 0.005) and mu21 (p < 0.001). CTX decreased in int vs. mu38 (p = 0.006) and mu21 (p = 0.005). Conclusion: The hot bath appears indifferent in relation to osteoporosis, while cold mud-bath shows good effect on bone metabolism. The cold mud-baths help to reduce arthritic inflammation and pain and thereby lead to higher mobility with positive consequence on bone.

scholarly journals Do we need to perform bilateral hip bone mineral density examination?

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Annisa Layalia Widjanarko
Keyword(s):  
Bone Mineral Density ◽  
General Hospital ◽  
Bone Mineral ◽  
Dual Energy ◽  
World Health ◽  
Mineral Density ◽  
Left Femur ◽  
X Ray ◽  
Bone Status ◽  
Bmd Testing

Background: Bone mineral density (BMD) measurement is one of the method for making osteoporosis diagnosis. World Health Organization (WHO) recommends the measurement of BMD conducted at antero-posterior lumbar vertebrae, unilateral hip (femur), and radius. However, there was a concern about osteoporosis under diagnosis if the measurement is only conducted at unilateral hip. Some studies found significant differences of BMD between both femur and evidence of the importance to examine both femur in making the diagnosis of osteoporosis. This study aims to determine anydifference between right and left femur BMD measurement and to investigate the bone status result with measurement of BMD of bilateral femur in Hasan Sadikin General Hospital. Methods: A retrospective study was conducted from June to November 2015. Patients who received dual-femur BMD testing using General Electrics (GE) Lunar Prodigy dual-energy x-ray absorptiometry at the DXA Facility in Hasan Sadikin General Hospital,Bandung between January 1, 2006 to December 31, 2014 were included. Statistical analysis performed to assess the difference and the correlation between theBMD of two femurs (g/cm2). T-scores of the subject were implemented into bone status according to WHO Diagnostic Criteria for Osteoporosis.Results: From sixty-one patients included in this study, there were difference bone status resulted from BMD of the femoral neck, Ward’s triangle, trochanter, andtotal hip area between right and left femur, although no statistically significance were found. There was a positive correlation between BMD of right and left femurat all areas of femur. There were 16 subjects (26.1%) showed combination level of bone status (normal, osteopenia, or osteoporosis in one femur).Conclusion: BMD results in each area of the right and left femurs are different.Therefore, performing bilateral hip BMD examination as a routine measurement for makingdiagnosis of osteoporosis is important.Keywords: Bone Mineral Density, Dual-energy X-ray Absorptiometry, Femur, Osteoporosis

scholarly journals Validation and Optimization of Proximal Femurs Microstructure Analysis Using High Field and Ultra-High Field MRI

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1603
Author(s):  
Enrico Soldati ◽  
Jerome Vicente ◽  
Daphne Guenoun ◽  
David Bendahan ◽  
Martine Pithioux
Keyword(s):  
High Field ◽  
Intraclass Correlation ◽  
Bone Microstructure ◽  
Fracture Load ◽  
P Value ◽  
Morphological Parameters ◽  
Compression Tests ◽  
Mineral Density ◽  
Trabecular Thickness ◽  
X Ray

Trabecular bone could be assessed non-invasively using MRI. However, MRI does not yet provide resolutions lower than trabecular thickness and a comparative analysis between different MRI sequences at different field strengths and X-ray microtomography (μCT) is still missing. In this study, we compared bone microstructure parameters and bone mineral density (BMD) computed using various MRI approaches, i.e., turbo spin echo (TSE) and gradient recalled echo (GRE) images used at different magnetic fields, i.e., 7T and 3T. The corresponding parameters computed from μCT images and BMD derived from dual-energy X-ray absorptiometry (DXA) were used as the ground truth. The correlation between morphological parameters, BMD and fracture load assessed by mechanical compression tests was evaluated. Histomorphometric parameters showed a good agreement between 7T TSE and μCT, with 8% error for trabecular thickness with no significative statistical difference and a good intraclass correlation coefficient (ICC > 0.5) for all the extrapolated parameters. No correlation was found between DXA-BMD and all morphological parameters, except for trabecular interconnectivity (R2 > 0.69). Good correlation (p-value < 0.05) was found between failure load and trabecular interconnectivity (R2 > 0.79). These results suggest that MRI could be of interest for bone microstructure assessment. Moreover, the combination of morphological parameters and BMD could provide a more comprehensive view of bone quality.

scholarly journals Evaluation of relationship between bone mineral density and fragility fracture in perimenopausal women between 40-58 years of age: a hospital based prospective observational study

2019 ◽  
Vol 5 (4) ◽  
pp. 605
Author(s):  
Arvind Kumar ◽  
Mozammil Pheroz ◽  
Rajesh K. Chopra ◽  
Benthungo Tungoe ◽  
Narendra Kumar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Risk Assessment ◽  
Bone Mineral ◽  
Fragility Fracture ◽  
Mineral Density ◽  
Left Femur ◽  
X Ray ◽  
Total Hip ◽  
Perimenopausal Women ◽  
Bony Injury

<p class="abstract"><strong>Background:</strong> At present the risk assessment for osteoporosis using low bone mineral density (BMD) is based on data obtained from elderly females, largely ≥ 65 years of age. The risk factors for low peak bone mass or accelerated bone loss that occurs during perimenopausal phase is ignored in this risk assessment. Osteoporosis is found to occur at a relatively younger age in the Indian population. Although lower BMD values have an established identity as a major risk factor for fractures in postmenopausal women, we endeavour to evaluate relationship between bone mineral density and fragility fracture in perimenopausal women.</p><p class="abstract"><strong>Methods:</strong> 65 Patients were recruited for the study. After X-ray of involved part, patients were divided into cases (with fracture, n=33) and control (no bony injury, n=32). All patients underwent dual energy X-ray absorptiometry (DEXA) scan. Results of DEXA scans were evaluated in both the groups. BMD was expressed in g/cm<sup>2</sup>.<strong></strong></p><p class="abstract"><strong>Results:</strong> 33 patients (50.77%) were diagnosed as fracture, 32(49.23%) had no bony injury. Threshold bone mineral density (BMD) for fragility fracture found out asfor L1, cut off ≤0.767. For L2, cut off ≤0.829. For L3, cut off ≤0.811. L4, cut off ≤0.798. For L1-L4, cut off ≤0.845. For left femur total hip, cut off ≤0.918. For left forearm-total, cut off ≤0.411. For right femur total hip-cut off ≤0.795. For right forearm-total, cut-off≤0.382.</p><p class="abstract"><strong>Conclusions:</strong> Perimenopausal women having BMD below threshold for involved site are at risk of fragility fracture and should be given prophylactic treatment to improve bone mineral density.</p>

Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients

2018 ◽  
Vol 69 (5) ◽  
pp. 1099-1105
Author(s):  
Violeta Bojinca ◽  
Claudiu Popescu ◽  
Andra Rodica Balanescu ◽  
Serban Mihai Balanescu ◽  
Mihai Bojinca
Keyword(s):  
Bone Metabolism ◽  
Bone Markers ◽  
Prostate Adenocarcinoma ◽  
Continuous Variables ◽  
Mineral Density ◽  
X Ray ◽  
T Score ◽  
Primary Prostate Cancer ◽  
Treatment Naïve ◽  
Group A

The objectives of the study were to evaluate bone metabolism in primary prostate cancer (PCa) patients prior to any treatment and to compare estrogens and anti-androgens in terms of bone metabolism. The study prospectively included consecutive patients with primary PCa who were proposed for radical prostatectomy and androgen deprivation therapy (ADT; either estrogens-group E, or anti-androgens -group A) and age-matched controls. Bone markers (osteoprotegerin -OPG; osteocalcin; deoxypyridinoline) were measured before treatment and after 6 months. Bone mineral density (BMD) was measured by dual X-ray absorptiometry before treatment and after 12 months (osteoporosis was defined as a spine or hip T score � -2.5). Continuous variables are reported as mean � standard deviation. The study included 30 controls (aged 70 � 6 years), 15 patients treated with estrogens (aged 71 � 6 years) and 15 patients with anti-androgens (aged 72 � 5 years). At baseline, 0% of controls, 33.3% of group E (p = 0.002 versus controls) and 53.3% of group A (p = 0.0001 versus controls) had osteoporosis. In group E, compared to baseline, OPG (4.67 � 1.38 versus 5.27 � 1.89; p = 0.043) and DPD (6.85 � 3.24 versus 8.63 � 2.42; p = 0.008) increased, while spine (0.99 � 0.32 versus 0.94 � 0.31; p = 0.019) BMD decreased. In group A, compared to baseline, OPG (6.37 � 3.04 versus 5.02 � 1.12; p = 0.041), spine (1.03 � 0.15 versus 0.89 � 0.15; p = 0.0003) and hip (0.82 � 0.18 versus 0.75 � 0.17; p = 0.003) BMD decreased. Osteoporosis is prevalent among hormone-na�ve PCa patients. Estrogens are associated with an increase of serum OPG, while anti-androgens with a decrease of serum OPG. Irrespective of ADT type, BMD still decreases in primary PCa patients.

scholarly journals Nível de atividade física no lazer após a cirurgia bariátrica afeta parâmetros ósseos?

2018 ◽  
Vol 20 (2) ◽  
pp. 146-154
Author(s):  
Alexandre Do Santos Cremon ◽  
Anselmo Alexandre Mendes ◽  
Caio Machado de Oliveira Terra ◽  
Leticia Andrade Cerrone ◽  
Nelson Nardo Junior
Keyword(s):  
Bone Markers ◽  
Leisure Time Physical Activity ◽  
Positive Impact ◽  
Statistical Significance ◽  
Mineral Density ◽  
Active Lifestyle ◽  
X Ray ◽  
Body Tissues ◽  
Small Effect Size ◽  
Circulating Levels

Bariatric surgery (BS) causes an exacerbated loss of body weight and fat, and can promote changes in other body tissues such as bone tissue. The aim of this study was to compare the profile of serum and urinary bone markers and bone mineral density (BMD) of active and sedentary patients after BS. The sample consisted of 89 patients, of both sexes, who underwent BS through the gastric bypass in Roux-Y, between years 2003 and 2013. Anthropometry, body composition, spine and femur BMD was evaluated by dual energy x-ray absormetry (DEXA), as well as biochemical variables through serum collected for the dosage of calcium, osteocalcin and PTH levels, and also 24-hours urine for deoxypyridinoline and calcium. The level of leisure-time physical activity was assessed by questionnaire. Statistical significance was set at 5%. The average age of active and sedentary groups was [51.76 (9.66)] and [47.06 (12.16)] and body mass index [34.98 (6.90)] and [29,26 (5.92)], respectively. There are statistically significant differences in osteocalcin levels between groups (p = 0.021), as well as small effect size observed in the following variables: BMD of the total femur, osteocalcin, deoxypyridinoline and serum calcium (respectively d = 0:36; d = 0:39; d = 00:41 d = 0.3). The incorporation of an active lifestyle demonstrated a positive impact on circulating levels of osteocalcin and other bone parameters, thereby indicating a possible preservation of BMD during the aging process. 

scholarly journals Assessment of the absorbed dose to organs from bone mineral density scan by using TLDS and the Monte Carlo method

2014 ◽  
Vol 29 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Alireza Karimian ◽  
Atefeh Hajarizadeh
Keyword(s):  
Bone Mineral Density ◽  
Monte Carlo ◽  
Monte Carlo Method ◽  
Bone Mineral ◽  
Absorbed Dose ◽  
Mineral Density ◽  
Left Femur ◽  
X Ray ◽  
Femur Bone ◽  
The Monte Carlo Method

Nowadays, dual energy X-ray absorptiometry is used in bone mineral density systems to assess the amount of osteoporosis. The purpose of this research is to evaluate patient organ doses from dual X-ray absorptiometry by thermoluminescence dosimeters chips and Monte Carlo method. To achieve this goal, in the first step, the surface dose of the cervix, kidney, abdomen region, and thyroid were measured by using TLD-GR 200 at various organ locations. Then, to evaluate the absorbed dose by simulation, the BMD system, patient's body, X-ray source and radiosensitive tissues were simulated by the Monte Carlo method. The results showed, for the spine (left femur) bone mineral density scan by using thermoluminescence dosimeters, the absorbed doses of the cervix and kidney were 4.5 (5.64) and 162.17 (3.99)(mGy), respectively. For spine (left femur) bone mineral density scan in simulation, the absorbed doses of the cervix and kidney were 4.19 (5.88) and 175 (3.68)(mGy), respectively. The data obtained showed that the absorbed dose of the kidney in the spine scan is noticeable. Furthermore, because of the small relative difference between the simulation and experimental results, the radiation absorbed dose may be assessed by simulation and software, especially for internal organs, and at different depths of otherwise inaccessible organs which is not possible in experiments.

scholarly journals Association between Body Mass Index and Bone Mineral Density in Patients Referred for Dual-Energy X-Ray Absorptiometry Scan in INMAS, Sylhet

2021 ◽  
Vol 22 (2) ◽  
pp. 108-113
Author(s):  
Kamun Nahar ◽  
Mohammed Mehedi Al Zahid Bhuiyan ◽  
Muhammad Sirazul Munir ◽  
Habibur Rahman
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Dual Energy ◽  
Age Group ◽  
Mineral Density ◽  
Left Femur ◽  
X Ray ◽  
T Score ◽  
Pearson's Correlation

With an aging population, osteoporosis is increasingly becoming a public health concern. Bangladesh has a high incidence of osteoporosis and occurs among a relatively younger age group than in the developed world. There are several factors that could be associated with bone mineral density (BMD). We are keen to determine the association with BMD and BMI. The study was carried out on 152 patients who were referred to INMAS for dual energy X- ray absorptiometry (DEXA) measurement of bone mineral density (BMD) during the periods of January 2018 to July 2019. BMD was measured at right femoral neck and lumbar spines. Data about age and sex, BMI were recorded. Reporting was done according to the T score following WHO criteria. Prevalence were compared using chi-squared tests. Among 152 patients, 84.9% were females and 15.1% were males. Results showed for right femur that normal bone density in 91 (59.1%), osteopenia in 54 (35.1%), osteoporosis in 9 (5.8%) and BMD in spine was normal in 57 (37.0%) osteopenia in 44 (28.6%), osteoporosis in 53 (34.4%). About 60% of the study population was normal weight and others were underweighted or overweighed. Status of BMD was associated with BMI in the lumbar spine and femur. In this study group, total 61.2% and 26.3%were found low BMD in spine and right femur respectively. In age group ≥ 60 years, low BMD in spinewas 72.0% that is 42.29% higher compare to below 60 years’ group (50.6%).Correlation of BMI with lumbar spine T score, right femur and left femur T score were measured by Pearson’s correlation coefficient test. Positive significant Pearson’s correlation was observedbetween BMI with spine T score (r = 0.397; p = <0.001), BMI with right femur T score (r = 0.347; p = <0.001) and BMI with left femur T score (r = 0.382; p = <0.001). Bangladesh J. Nuclear Med. 22(2): 108-113, Jul 2019

scholarly journals Flaxseed oil ameliorated high-fat-diet-induced bone loss in rats by promoting osteoblastic function in rat primary osteoblasts

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Fulian Chen ◽  
Yan Wang ◽  
Hongwei Wang ◽  
Zhenhua Dong ◽  
Yan Wang ◽  
...  
Keyword(s):  
Cortical Bone ◽  
High Fat Diet ◽  
Bone Markers ◽  
Maximum Load ◽  
Biomechanical Properties ◽  
Flaxseed Oil ◽  
Fracture Load ◽  
Bone Volume ◽  
High Fat ◽  
Mineral Density

Abstract Background α-Linolenic acid (ALA) is a plant-derived omega-3 unsaturated fatty acid that is rich in flaxseed oil (FO). The effect of FO on bone health is controversial. This study aims to evaluate the effect of FO on bone damage induced by a high-fat diet (HFD) and to explore the possible mechanism. Methods Male Sprague-Dawley rats were fed a normal control diet (NC, 10% fat), FO diet (NY, 10% fat), HFD (60% fat), or HFD containing 10% FO (HY, 60% fat) for 22 weeks. Micro CT and three-point bending tests were conducted to evaluate bone microstructure and biomechanics. Serum was collected for the detection of ALP, P1NP, and CTX-1. Rat primary osteoblasts (OBs) were treated with different concentrations of ALA with or without palmitic acid (PA) treatment. The ALP activity, osteogenic-related gene and protein expression were measured. Results Rats in the HFD group displayed decreased biomechanical properties, such as maximum load, maximum fracture load, ultimate tensile strength, stiffness, energy absorption, and elastic modulus, compared with the NC group (p < 0.05). However, HY attenuated the HFD-induced decreases in bone biomechanical properties, including maximum load, maximum fracture load, and ultimate tensile strength (p < 0.05). Trabecular bone markers such as trabecular volume bone mineral density (Tb. vBMD), trabecular bone volume/total volume (Tb. BV/TV), trabecular number (Tb. N), trabecular thickness (Tb. Th) were decreased, trabecular separation (Tb. Sp) and the structure model index (SMI) were increased in the HFD group compared with the NC group, and all parameters were remarkably improved in the HY group compared to the HFD group (p < 0.05). However, cortical bone markers such as cortical volume bone mineral density (Ct. vBMD), cortical bone volume/total volume (Ct. BV/TV) and cortical bone thickness (Ct. Th) were not significantly different among all groups. Moreover, the serum bone formation markers ALP and P1NP were higher and the bone resorption marker CTX-1 was lower in the HY group compared with levels in the HFD group. Compared with the NC group, the NY group had no difference in the above indicators. In rat primary OBs, PA treatment significantly decreased ALP activity and osteogenic gene and protein (β-catenin, RUNX2, and osterix) expression, and ALA dose-dependently restored the inhibition induced by PA. Conclusions FO might be a potential therapeutic agent for HFD-induced bone loss, most likely by promoting osteogenesis.

scholarly journals Radial Quantitative Ultrasound and Dual Energy X-Ray Absorptiometry: Intermethod Agreement for Bone Status Assessment in Children

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Kar Hau Chong ◽  
Bee Koon Poh ◽  
Nor Aini Jamil ◽  
Nor Azmi Kamaruddin ◽  
Paul Deurenberg
Keyword(s):  
Quantitative Ultrasound ◽  
Dual Energy ◽  
Whole Body ◽  
Poor Agreement ◽  
Mineral Density ◽  
Limits Of Agreement ◽  
X Ray ◽  
Bone Status ◽  
Status Assessment ◽  
Body Bone

Aim. To validate a radial quantitative ultrasound (QUS) system with dual energy X-ray absorptiometry (DXA), a criterion technique in bone status assessment among children.Methods. Bone health was evaluated using a radial QUS system (Sunlight Omnisense 8000P) to measure the speed of sound (SOS) at one-third distal radius of the nondominant hand and DXA (Hologic QDR) was used to assess whole body bone mineral density (BMD).Results. Some 29.9% of the children were grossly misclassified according to quartiles of BMD and radial SOS. Poor agreement was observed betweenZ-scores of radial SOS and whole-body BMD (mean difference = 0.6 ± 0.9; 95% limits of agreement = −1.4 to 2.6). With a cut-off value of −1.0, radial SOS yielded satisfactory sensitivity (80%) and specificity (93%) for the detection of children with low BMD.Conclusion. The observed poor agreement in the present study suggests that radial QUS and DXA are not comparable and hence are not interchangeable in evaluating bone status of the children.

Sign in / Sign up

Export Citation Format

Share Document