Investigation of the Relationship Between Suicide Attempt and Adult Attention-Deficit/Hyperactivity Disorder Symptoms in Bipolar Disorder

BackgroundAttention-deficit hyperactivity disorder (ADHD) and anxiety disorders have been proposed as precursors of bipolar disorder, but their joint and relative roles in the development of bipolar disorder are unknown.AimsTo test the prospective relationship of ADHD and anxiety with onset of bipolar disorder.MethodWe examined the relationship between ADHD, anxiety disorders and bipolar disorder in a birth cohort of 2 409 236 individuals born in Denmark between 1955 and 1991. Individuals were followed from their sixteenth birthday or from January 1995 to their first clinical contact for bipolar disorder or until December 2012. We calculated incidence rates per 10 000 person-years and tested the effects of prior diagnoses on the risk of bipolar disorder in survival models.ResultsOver 37 394 865 person-years follow-up, 9250 onsets of bipolar disorder occurred. The incidence rate of bipolar disorder was 2.17 (95% CI 2.12–2.19) in individuals with no prior diagnosis of ADHD or anxiety, 23.86 (95% CI 19.98–27.75) in individuals with a prior diagnosis of ADHD only, 26.05 (95% CI 24.47–27.62) in individuals with a prior diagnosis of anxiety only and 66.16 (95% CI 44.83–87.47) in those with prior diagnoses of both ADHD and anxiety. The combination of ADHD and anxiety increased the risk of bipolar disorder 30-fold (95% CI 21.66–41.40) compared with those with no prior ADHD or anxiety.ConclusionsEarly manifestations of both internalising and externalising psychopathology indicate liability to bipolar disorder. The combination of ADHD and anxiety is associated with a very high risk of bipolar disorder.Declaration of interestNone.

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Physical Fitness and Resting EEG in Children With Attention Deficit Hyperactivity Disorder

Journal of Psychophysiology ◽

10.1027/0269-8803/a000131 ◽

2015 ◽

Vol 29 (1) ◽

pp. 26-32 ◽

Cited By ~ 7

Author(s):

Ching-Wen Huang ◽

Chung-Ju Huang ◽

Chiao-Ling Hung ◽

Chia-Hao Shih ◽

Tsung-Min Hung

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Physical Fitness ◽

Attention Deficit ◽

Resting State ◽

Self Control ◽

Children With Adhd ◽

Hyperactivity Disorder ◽

Higher Power ◽

Eyes Open ◽

The Relationship

Children with attention deficit hyperactivity disorder (ADHD) are characterized by a deviant pattern of brain oscillations during resting state, particularly elevated theta power and increased theta/alpha and theta/beta ratios that are related to cognitive functioning. Physical fitness has been found beneficial to cognitive performance in a wide age population. The purpose of the present study was to investigate the relationship between physical fitness and resting-state electroencephalographic (EEG) oscillations in children with ADHD. EEG was recorded during eyes-open resting for 28 children (23 boys and 5 girls, 8.66 ± 1.10 years) with ADHD, and a battery of physical fitness assessments including flexibility, muscular endurance, power, and agility tests were administered. The results indicated that ADHD children with higher power fitness exhibited a smaller theta/alpha ratio than those with lower power fitness. These findings suggest that power fitness may be associated with improved attentional self-control in children with ADHD.

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Faculty Opinions recommendation of Comparative mortality risk in adult patients with schizophrenia, depression, bipolar disorder, anxiety disorders, and attention-deficit/hyperactivity disorder participating in psychopharmacology clinical trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718106482.793483712 ◽

2013 ◽

Author(s):

Driss Moussaoui ◽

Adil Khoubila

Keyword(s):

Bipolar Disorder ◽

Attention Deficit Hyperactivity Disorder ◽

Clinical Trials ◽

Anxiety Disorders ◽

Mortality Risk ◽

Attention Deficit ◽

Adult Patients ◽

Hyperactivity Disorder

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Faculty Opinions recommendation of Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.8164974.8606054 ◽

2011 ◽

Author(s):

Daniel Dickstein ◽

Rebecca Siegel

Keyword(s):

Bipolar Disorder ◽

Attention Deficit Hyperactivity Disorder ◽

Response Inhibition ◽

Attention Deficit ◽

Neural Correlates ◽

Pediatric Bipolar Disorder ◽

Hyperactivity Disorder

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The relationship between attention deficit hyperactivity disorder and premature infants in Taiwanese: a case control study

BMC Psychiatry ◽

10.1186/1471-244x-12-85 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 11

Author(s):

Shih-Ming Chu ◽

Ming-Horng Tsai ◽

Fan-Ming Hwang ◽

Jen-Fu Hsu ◽

Hsuan Rong Huang ◽

...

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Premature Infants ◽

Attention Deficit ◽

Case Control Study ◽

Case Control ◽

Hyperactivity Disorder ◽

The Relationship ◽

Control Study

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Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

Psychological Medicine ◽

10.1017/s0033291721001951 ◽

2021 ◽

pp. 1-8

Author(s):

L. Propper ◽

A. Sandstrom ◽

S. Rempel ◽

E. Howes Vallis ◽

S. Abidi ◽

...

Keyword(s):

Bipolar Disorder ◽

Attention Deficit Hyperactivity Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Mood Disorder ◽

Attention Deficit ◽

Neurodevelopmental Disorders ◽

Autism Spectrum ◽

Major Depressive ◽

Hyperactivity Disorder

Abstract Background Offspring of parents with major mood disorders (MDDs) are at increased risk for early psychopathology. We aim to compare the rates of neurodevelopmental disorders in offspring of parents with bipolar disorder, major depressive disorder, and controls. Method We established a lifetime diagnosis of neurodevelopmental disorders [attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disabilities, specific learning disorders, and motor disorders] using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version in 400 participants (mean age 11.3 + s.d. 3.9 years), including 93 offspring of parents with bipolar disorder, 182 offspring of parents with major depressive disorder, and 125 control offspring of parents with no mood disorder. Results Neurodevelopmental disorders were elevated in offspring of parents with bipolar disorder [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.23–4.47, p = 0.010] and major depressive disorder (OR 1.87, 95% CI 1.03–3.39, p = 0.035) compared to controls. This difference was driven by the rates of ADHD, which were highest among offspring of parents with bipolar disorder (30.1%), intermediate in offspring of parents with major depressive disorder (24.2%), and lowest in controls (14.4%). There were no significant differences in frequencies of other neurodevelopmental disorders between the three groups. Chronic course of mood disorder in parents was associated with higher rates of any neurodevelopmental disorder and higher rates of ADHD in offspring. Conclusions Our findings suggest monitoring for ADHD and other neurodevelopmental disorders in offspring of parents with MDDs may be indicated to improve early diagnosis and treatment.

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