scholarly journals The history and evolution of immunoglobulin products and their clinical indications

2015 ◽  
Vol 2 (4) ◽  
pp. 181-194 ◽  
Author(s):  
John A. Hooper
Keyword(s):  
Gamma Globulin ◽  
Immunoglobulin Therapy ◽  
Clinical Indication ◽  
Immune Globulins ◽  
History Of ◽  
Intravenous Gamma Globulin ◽  
Human Gamma Globulin ◽  
Clinical Conditions ◽  
The 19Th Century

The history of providing antibodies to treat diseases began in the 19th century with the discovery of tetanus and diphtheria toxins and the demonstration that immunity to tetanus and diphtheria infections could be transferred by immune sera. Characterization of the mediators of this immunity resulted in the discovery that antibodies are proteins that can be isolated and used to protect against infectious diseases. Development of a method to isolate antibodies from human plasma that could be safely injected into people initiated the development of human gamma globulin preparations to provide antibodies to patients with inherited antibody deficiencies. To overcome the limitations imposed by intramuscular injection of gamma globulin, intravenous gamma globulin preparations were developed that began to be used in a wide variety of clinical conditions. Thus the original clinical indication for infection prevention was expanded to several other indications that employ large doses to suppress inflammatory and autoimmune disorders. The most recent development in immunoglobulin therapy is the production of concentrated immune globulins for subcutaneous injection. Home infusions of subcutaneous immunoglobulin are increasingly used to treat immunodeficient patients and are being studied for other clinical applications.

scholarly journals Devic's Neuromyelitis Optica Treated with Intravenous Gamma Globulin (IVIG)

2004 ◽  
Vol 31 (2) ◽  
pp. 265-267 ◽  
Author(s):  
Jacqueline Bakker ◽  
Luanne Metz
Keyword(s):  
Gamma Globulin ◽  
Demyelinating Disease ◽  
Preventive Intervention ◽  
Treatment Options ◽  
Neurological Status ◽  
Neurological Impairment ◽  
Devic’S Syndrome ◽  
Optimal Dosing ◽  
History Of ◽  
Intravenous Gamma Globulin

AbstractBackground:Devic's syndrome is a demyelinating disease of the spinal cord and optic nerves. It tends to have a poor prognosis, probably due to the occurrence of necrosis within lesions. There is no proven effective treatment although relapses are commonly treated with corticosteroids and people with recurrent attacks may be managed with chronic immune suppressing treatments. Intravenous gamma globulin (IVIG) and plasma exchange are reasonable treatment options because Devic's syndrome is believed to be antibody mediated. We report two patients of Devic's syndrome that stabilized following initiation of monthly IVIG.Patient 1:A 42-year-old woman with a 23 year history of Devic's syndrome continued to have frequent attacks of optic neuritis unresponsive to daily corticosteroids and azathioprine. Since initiation of monthly IVIG 5/2 years ago she has had no further definite attacks. She has also noted minimal improvement in color perception.Patient 2:A 58-year-old woman with a three year history of Devic's syndrome experienced five attacks during the first 16 months of disease. Monthly IVIG was associated with complete cessation of relapses and significantly improved neurological status over one year of treatment.Conclusions:Because active Devic's disease often results in severe, permanent neurological impairment, preventive intervention should be considered. These cases suggest that IVIG may be effective in preventing attacks and possibly in enhancing neurological recovery. Randomized controlled trials will be needed to confirm this and to determine optimal dosing and treatment duration.

scholarly journals Teaching Modern Greek to Classicists

2020 ◽  
Vol 22 (2) ◽  
pp. 119-139
Author(s):  
Jerneja Kavčič ◽  
Brian Daniel Joseph ◽  
Christopher Brown
Keyword(s):  
Teaching Practice ◽  
Hellenistic Period ◽  
Greek Language ◽  
Ancient Greek ◽  
Modern Language ◽  
Modern Greek ◽  
History Of ◽  
Carry Over ◽  
The 19Th Century

The ideology of decline is a part of the history of the study and characterization of the Greek language from the Hellenistic period and the Roman Atticist movement right up to the emergence of katharevousa in the 19th century and the resulting modern diglossia. It is also clear, however, that there is an overwhelming presence of Ancient Greek vocabulary and forms in the modern language. Our position is that the recognition of such phenomena can provide a tool for introducing classicists to the modern language, a view that has various intellectual predecessors (e.g., Albert Thumb, Nicholas Bachtin, George Thomson, and Robert Browning). We thus propose a model for the teaching of Modern Greek to classicists that starts with words that we refer to as carry-overs. These are words that can be used in the modern language without requiring any explanation of pronunciation rules concerning Modern Greek spelling or of differences in meaning in comparison to their ancient predecessors (e.g., κακός ‘bad’, μικρός ‘small’, νέος ‘new’, μέλι ‘honey’, πίνετε ‘you drink’). Our data show that a beginners’ textbook of Ancient Greek may contain as many as a few hundred carry-over words, their exact number depending on the variety of the Erasmian pronunciation that is adopted in the teaching practice. However, the teaching of Modern Greek to classicists should also take into account lexical phenomena such as Ancient-Modern Greek false friends, as well as Modern Greek words that correspond to their ancient Greek predecessors only in terms of their written forms and meanings.

scholarly journals From the Identification to the Dissection of the Physiological Role of the Mitochondrial Calcium Uniporter: An Ongoing Story

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 786
Author(s):  
Giorgia Pallafacchina ◽  
Sofia Zanin ◽  
Rosario Rizzuto
Keyword(s):  
3D Structure ◽  
Physiological Role ◽  
Muscle Physiology ◽  
Calcium Uniporter ◽  
Gene Coding ◽  
History Of ◽  
The 19Th Century ◽  
The Impact

The notion of mitochondria being involved in the decoding and shaping of intracellular Ca2+ signals has been circulating since the end of the 19th century. Despite that, the molecular identity of the channel that mediates Ca2+ ion transport into mitochondria remained elusive for several years. Only in the last decade, the genes and pathways responsible for the mitochondrial uptake of Ca2+ began to be cloned and characterized. The gene coding for the pore-forming unit of the mitochondrial channel was discovered exactly 10 years ago, and its product was called mitochondrial Ca2+ uniporter or MCU. Before that, only one of its regulators, the mitochondria Ca2+ uptake regulator 1, MICU1, has been described in 2010. However, in the following years, the scientific interest in mitochondrial Ca2+ signaling regulation and physiological role has increased. This shortly led to the identification of many of its components, to the description of their 3D structure, and the characterization of the uniporter contribution to tissue physiology and pathology. In this review, we will summarize the most relevant achievements in the history of mitochondrial Ca2+ studies, presenting a chronological overview of the most relevant and landmarking discoveries. Finally, we will explore the impact of mitochondrial Ca2+ signaling in the context of muscle physiology, highlighting the recent advances in understanding the role of the MCU complex in the control of muscle trophism and metabolism.

scholarly journals The clinical response of West Nile virus neuroinvasive disease to intravenous immunoglobulin therapy

2012 ◽  
Vol 2 (1) ◽  
pp. 18 ◽  
Author(s):  
Zvi Shimoni ◽  
Hanna Bin ◽  
Shlomo Bulvik ◽  
Mark Niven ◽  
Rawi Hazzan ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Gamma Globulin ◽  
Immunoglobulin Therapy ◽  
Ivig Treatment ◽  
Partial Recovery ◽  
West Nile ◽  
Intravenous Immunoglobulin Therapy ◽  
Neuroinvasive Disease ◽  
Intravenous Gamma Globulin ◽  
Neurological Response

The aim of the study was to determine whether intravenous gamma globulin (IVIG) treatment is effective in patients with West Nile Virus (WNV) neuroinvasive disease. We contacted hospital based infectious disease experts in Israeli hospitals to identify patients with WNV neuroinvasive disease who were treated with IVIG. The main outcome measure was neurological response after treatment. There were 12 patients who received IVIG and four improved within 48 h. Three patients died, 6 had partial recovery, and 3 recovered completely. Eleven of the 12 patients were infected with Israeli genotypes that are highly homologous to Europe/Africa viruses. The rapid response in some patients suggests that IVIG is effective, and might be used to treat patients with WNV neuroinvasive disease with IVIG.

PCR-RFLP Detection od PAI-2 Gene Variants: Prevelence in Ethnic Groups and Disease Relationship in patients Undergoing corony Angiography

1997 ◽  
Vol 77 (05) ◽  
pp. 0955-0958 ◽  
Author(s):  
Carole A Foy ◽  
Peter J Grant
Keyword(s):  
Gene Variants ◽  
Genotype Distribution ◽  
Pima Indians ◽  
Significant Difference ◽  
Pcr Rflp ◽  
History Of ◽  
Caucasian Patients ◽  
Clinical Conditions ◽  
Rflp Assay ◽  
Coronary Atheroma

SummaryPAI-2 is a fibrinolytic inhibitor produced predominantly by monocytes. Most PAI-2 is intracellular making study in clinical conditions difficult. Abnormalities in production may be associated with inflammation and fibrinolysis at sites of tissue damage such as the atherosclerotic plaque.PAI-2 gene variants have been described: variant A consists of Asn120, Asn404 and Ser413 and variant B consists of Asp120, Lys404 and Cys413. We designed a PCR-RFLP assay using primers spanning the region containing Asn/Lys404 and Ser/Cys413. Variant B contains an Mwol restriction site. We analysed 302 Pima Indians and 286 healthy Caucasian volunteers. To investigate relationships between genotype and vascular disease we analysed 333 Caucasian patients undergoing coronary angiography.Gene variant B was more common in the Pimas than in Caucasians (p <0.0001). There was no significant difference in genotype distribution between the volunteers and patients. In the patients there was no association between genotype and either a history of MI or extent of coronary atheroma.

Historian of the Russian State Library. In Memory of L.M. Koval (1933—2020)

2020 ◽  
Vol 69 (2) ◽  
pp. 167-172
Author(s):  
Margarita Y. Dvorkina
Keyword(s):  
20Th Century ◽  
Foreign Languages ◽  
Library History ◽  
Russian State ◽  
Great Patriotic War ◽  
History Of ◽  
Publishing Houses ◽  
October 17 ◽  
State Library ◽  
The 19Th Century

The article is devoted to the memory of Lyudmila Mikhailovna Koval (October 17, 1933 – February 15, 2020), historian, Head of the History sector of the Russian State Library (RSL) and the Museum of Library history. The author presents brief biographical information about L.M. Koval, the author of more than 350 scientific and popular scientific works in Russian and in 9 foreign languages. She published 29 books in Publishing houses “Nauka”, “Kniga”, “Letniy Sad”, ”Pashkov Dom”, most of the works are dedicated to the Library. Special place in the work of L.M. Koval is given to the Great Patriotic War theme. The article considers the works devoted to the activities of Library staff during the War period. L.M. Koval paid much attention to the study of activities of the Library’s Directors. She prepared books and articles about the Directors of the Moscow Public and Rumyantsev Museums and Library from the end of the 19th century and almost to the end of the 20th century: N.V. Isakov, D.S. Levshin, V.A. Dashkov, M.A. Venevitinov, I.V. Tsvetaev, V.D. Golitsyn, A.K. Vinogradov, V.I. Nevsky, N.M. Sikorsky. The author notes contribution of L.M. Koval to the study of the Library’s history. Specialists in the history of librarianship widely use bibliography of L.M. Koval in their research. The list of sources contains the main works of L.M. Koval, and the Appendix includes reviews of publications by L.M. Koval and the works about her.

MASJID BESAR RAJA HAJI ABDUL GHANI PULAU BURU KEPULAUAN RIAU

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Nurman Kholis
Keyword(s):  
Qualitative Research ◽  
Research Methods ◽  
19Th Century ◽  
Qualitative Research Methods ◽  
District Level ◽  
History Of ◽  
Chinese Buddhists ◽  
The Right ◽  
The 19Th Century ◽  
Level Government

Abstract. Many Muslims in the Riau Islands do not know the history of the development of Islamic theory from the center of power to spread to various corners. This is as the existence of the Great Mosque of Raja Haji Abdul Ghani (MBRHAG) on Buru Island, Karimun. Thus, to uncover the existence of this mosque, qualitative research methods are used so that history, architecture, and socio-religious functions can be known. Based on the results of the study it was concluded that the establishment of MBRHAG was initiated by Raja Haji Abdul Ghani. He was the first Amir (sub-district level government) of the kingdom of Riau-Lingga on Buru Island, in the 19th century. The architecture is a Chinese. Therefore, on the right side of this mosque is around 200 m, there is also the Sam Po Teng Temple and the Tri Dharma Dewa Bumi. Thus, the close location of the mosque with Chinese and Confucian worship houses's shows a harmonious relationship between Malay Muslims and Chinese Buddhists. In fact, in the continuation of this relationship there was information that a Chinese Buddhist had joined a Muslim friend to fast for half a month of Ramadan.Keywords: Mosque, Malay Muslims, Chinese Buddhists/Confucians, Harmonious RelationsAbstrak. Umat Islam di Kepulauan Riau banyak yang tidak mengenal sejarah perkembangan ajaran Islam dari pusat kekuasaan hingga tersebar ke berbagai pelosok. Hal ini sebagaimana keberadaan Masjid Besar Raja Haji Abdul Ghani (MBRHAG) di Pulau Buru, Karimun. Dengan demikian, untuk mengungkapkan keberadaan masjid ini digunakan metode penelitian kualitatif  agar dapat diketahui sejarah, arsitektur, dan fungsi sosial keagamaannya.  Berdasarkan hasil penelitian diperoleh kesimpulan bahwa pendirian MBRHAG diprakarsai oleh Raja Haji Abdul Ghani. Ia adalah Amir (pemerintah setingkat kecamatan) pertama kerajaan Riau-Lingga di Pulau Buru, pada abad ke-19. Adapun arsitekturnya adalah seorang Tionghoa. Karena itu, di sebelah kanan masjid ini sekitar 200 m juga terdapat Kelenteng Sam Po Teng dan cetya Tri Dharma Dewa Bumi. Dengan demikian, dekatnya lokasi masjid dengan rumah ibadah umat Tionghoa dan Khonghucu ini menunjukkan hubungan yang harmonis antara muslim Melayu dengan Budhis Tionghoa. Bahkan, dalam kelangsungan hubungan ini terdapat informasi seorang Buddhis Tionghoa pernah ikut temannya yang beragama muslim untuk berpuasa selama setengah bulan Ramadhan.Kata Kunci: Masjid, Muslim Melayu, Buddhis/Khonghucu Tionghoa, Hubungan Harmonis

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