scholarly journals Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults

2016 ◽  
Vol 4 (13) ◽  
pp. e12849 ◽  
Author(s):  
Kyle D. Flack ◽  
Brenda M. Davy ◽  
Martin DeBerardinis ◽  
Nabil E. Boutagy ◽  
Ryan P. McMillan ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Oxidative Capacity ◽  
Resistance Exercise Training ◽  
Muscle Oxidative Capacity

scholarly journals Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults

2018 ◽  
Vol 103 ◽  
pp. 101-106 ◽  
Author(s):  
Ciriaco Carru ◽  
Mariasole Da Boit ◽  
Panagiotis Paliogiannis ◽  
Angelo Zinellu ◽  
Salvatore Sotgia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Resistance Exercise Training ◽  
Markers Of Oxidative Stress ◽  
And Function

scholarly journals Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults

2019 ◽  
Vol 127 ◽  
pp. 110723 ◽  
Author(s):  
Tatiana Moro ◽  
Camille R. Brightwell ◽  
Danielle E. Phalen ◽  
Colleen F. McKenna ◽  
Samantha J. Lane ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Muscle Adaptation ◽  
Resistance Exercise Training

Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 34 (3) ◽  
pp. 348-354 ◽  
Author(s):  
M. A. Tarnopolsky
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Satellite Cells ◽  
Peer Review Process ◽  
Functional Independence ◽  
Resistance Exercise Training

Aging is associated with a reduction in muscle mass and strength, which compromises functional independence. Skeletal muscle also shows an increase in mitochondrial dysfunction and oxidative stress in older adults. Resistance-exercise training is an important countermeasure for aging-associated muscle weakness. It has been shown that resistance-exercise training increases muscle strength and function in older adults, in association with a reduction in markers of oxidative stress and an improvement in mitochondrial function. Patients with sporadic mitochondrial cytopathies show an accumulation of mitochondrial DNA mutations and deletions in mature muscle, but not in satellite cells. Such patients have shown an activation of the satellite cells following myotoxic trauma and resistance, likely due to a fusion of the relatively quiescent satellite cells with mature muscle, which dilutes the mutational burden, a process called mitochondrial DNA shifting. Preliminary data strongly suggest that mitochondrial DNA shifting occurs in skeletal muscle from older adults following resistance-exercise training.

scholarly journals Type 2 Diabetes Reduces the Muscle Anabolic Effect of Resistance Exercise Training in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 529-529
Author(s):  
Amanda Randolph ◽  
Tatiana Moro ◽  
Adetutu Odejimi ◽  
Blake Rasmussen ◽  
Elena Volpi
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Muscle Strength ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Lean Mass ◽  
Synthesis Rate ◽  
Resistance Exercise Training ◽  
Appendicular Lean Mass

Abstract Type 2 Diabetes Mellitus (T2DM) accelerates the incidence and increases the prevalence of sarcopenia in older adults. This suggests an urgent need for identifying effective sarcopenia treatments for older adults with T2DM. It is unknown whether traditional approaches, such as progressive resistance exercise training (PRET), can effectively counteract sarcopenia in older patients with T2DM. To test the efficacy of PRET for the treatment of sarcopenia in older adults with T2DM, 30 subjects (15 T2DM and 15 age- and sex- matched controls) underwent metabolic testing with muscle biopsies before and after a 13-week full-body PRET program. Primary outcome measures included changes in appendicular lean mass, muscle strength, and mixed muscle fractional synthesis rate (FSR). Before PRET, BMI-adjusted appendicular lean mass was significantly lower in the T2DM group (0.7095±0.0381 versus 0.8151±0.0439, p<0.0001). As a result of PRET, appendicular lean mass adjusted for BMI and muscle strength increased significantly in both groups, but to a lesser extent for the T2DM group (p=0.0009) . Preliminary results for FSR (n=25) indicate that subjects with T2DM had lower basal FSR prior to PRET (p=0.0197) . Basal FSR increased significantly in the control group after PRET (p=0.0196), while it did not change in the T2DM group (p=0.3537). These results suggest that in older adults the positive effect of PRET on muscle anabolism and strength is reduced by T2DM . Thus, older adults with T2DM may require more intensive, multimodal and targeted sarcopenia treatment. Funded by NIH R01AG049611 and P30AG024832.

Vitamin D status and resistance exercise training independently affect glucose tolerance in older adults

2013 ◽  
Vol 33 (5) ◽  
pp. 349-357 ◽  
Author(s):  
Vanessa M. Kobza ◽  
James C. Fleet ◽  
Jing Zhou ◽  
Travis B. Conley ◽  
Munro Peacock ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Resistance Exercise ◽  
Vitamin D Status ◽  
Resistance Exercise Training

scholarly journals Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophy

2017 ◽  
Vol 99 ◽  
pp. 98-109 ◽  
Author(s):  
Michael J. Stec ◽  
Anna Thalacker-Mercer ◽  
David L. Mayhew ◽  
Neil A. Kelly ◽  
S. Craig Tuggle ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Trial ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Muscle Atrophy ◽  
Dose Response ◽  
Resistance Exercise Training ◽  
Age Related
Sign in / Sign up

Export Citation Format

Share Document